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Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies?
Gynecol Endocrinol 2013; 29(2):145-7GE

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of fertile age. It is associated with several risk factors and long-term health consequences. Chronic anovulation combined with relative estrogen excess and consequent prolonged stimulatory effect on the endometrium can lead to the pathogenesis of hormonal dependant carcinoma. PCOS is thus traditionally reported to be associated with increased risk of endometrial, as well as breast and ovarian cancers. This article provides a critical literature review of the relationship between PCOS and the incidence of estrogen-dependant gynecological tumours, and it then discusses whether the commonly cited risk factor association can be substantiated by high quality studies which comply with the requirements of "evidence-based medicine."

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Charles University, First Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic. michael.fanta@volny.cz

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23127146

Citation

Fanta, Michael. "Is Polycystic Ovary Syndrome, a State of Relative Estrogen Excess, a Real Risk Factor for Estrogen-dependant Malignancies?" Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 29, no. 2, 2013, pp. 145-7.
Fanta M. Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies? Gynecol Endocrinol. 2013;29(2):145-7.
Fanta, M. (2013). Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies? Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 29(2), pp. 145-7. doi:10.3109/09513590.2012.730575.
Fanta M. Is Polycystic Ovary Syndrome, a State of Relative Estrogen Excess, a Real Risk Factor for Estrogen-dependant Malignancies. Gynecol Endocrinol. 2013;29(2):145-7. PubMed PMID: 23127146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is polycystic ovary syndrome, a state of relative estrogen excess, a real risk factor for estrogen-dependant malignancies? A1 - Fanta,Michael, Y1 - 2012/11/05/ PY - 2012/11/7/entrez PY - 2012/11/7/pubmed PY - 2013/5/31/medline SP - 145 EP - 7 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 29 IS - 2 N2 - Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of fertile age. It is associated with several risk factors and long-term health consequences. Chronic anovulation combined with relative estrogen excess and consequent prolonged stimulatory effect on the endometrium can lead to the pathogenesis of hormonal dependant carcinoma. PCOS is thus traditionally reported to be associated with increased risk of endometrial, as well as breast and ovarian cancers. This article provides a critical literature review of the relationship between PCOS and the incidence of estrogen-dependant gynecological tumours, and it then discusses whether the commonly cited risk factor association can be substantiated by high quality studies which comply with the requirements of "evidence-based medicine." SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/23127146/Is_polycystic_ovary_syndrome_a_state_of_relative_estrogen_excess_a_real_risk_factor_for_estrogen_dependant_malignancies L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2012.730575 DB - PRIME DP - Unbound Medicine ER -