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Small sizes of TiO2-NPs exhibit adverse effects at predicted environmental relevant concentrations on nematodes in a modified chronic toxicity assay system.
J Hazard Mater. 2012 Dec; 243:161-8.JH

Abstract

In Caenorhabditis elegans, although acute toxicity of TiO(2) nanoparticles (TiO(2)-NPs) at high concentrations has been investigated, we still know little about chronic toxicity of TiO(2)-NPs. Our data here showed that acute TiO(2)-NPs exposure in the range of μg/L had no obviously adverse effects on nematodes, but the chronic toxicities of large sizes (60 nm and 90 nm) of TiO(2)-NPs in the range of μg/L were detected in nematodes in a modified chronic toxicity assay system. Moreover, chronic toxicities of small sizes (4 nm and 10nm) of TiO(2)-NPs in the range of ng/L were observed in nematodes with locomotion behavior and ROS production as endpoints. In nematodes chronically exposed to small sizes of TiO(2)-NPs at predicted environmental relevant concentrations, locomotion behavior was significantly (P<0.01) correlated with ROS production. Furthermore, treatment with antioxidants (ascorbate and N-acetyl-l-cysteine) inhibited both the induction of ROS production and the decrease of locomotion behaviors observed in nematodes chronically exposed to small sizes of TiO(2)-NPs at predicted environmental relevant concentrations. Therefore, chronic exposure to small sizes of TiO(2)-NPs at predicted environmental relevant concentrations can cause adverse effects on nematodes, and formation of such adverse effects may be largely due to the induction of oxidative stress.

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Authors+Show Affiliations

Wu Q
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing 210009, China.
Wang W
No affiliation info available
Li Y
No affiliation info available
Li Y
No affiliation info available
Ye B
No affiliation info available
Tang M
No affiliation info available
Wang D
No affiliation info available

MeSH

AcetylcysteineAnimalsAntioxidantsAscorbic AcidCaenorhabditis elegansGrowthIndicators and ReagentsIntestinesMotor ActivityNanoparticlesOxidative StressParticle SizeReactive Oxygen SpeciesSuspensionsTitanium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23127274

Citation

Wu, Qiuli, et al. "Small Sizes of TiO2-NPs Exhibit Adverse Effects at Predicted Environmental Relevant Concentrations On Nematodes in a Modified Chronic Toxicity Assay System." Journal of Hazardous Materials, vol. 243, 2012, pp. 161-8.
Wu Q, Wang W, Li Y, et al. Small sizes of TiO2-NPs exhibit adverse effects at predicted environmental relevant concentrations on nematodes in a modified chronic toxicity assay system. J Hazard Mater. 2012;243:161-8.
Wu, Q., Wang, W., Li, Y., Li, Y., Ye, B., Tang, M., & Wang, D. (2012). Small sizes of TiO2-NPs exhibit adverse effects at predicted environmental relevant concentrations on nematodes in a modified chronic toxicity assay system. Journal of Hazardous Materials, 243, 161-8. https://doi.org/10.1016/j.jhazmat.2012.10.013
Wu Q, et al. Small Sizes of TiO2-NPs Exhibit Adverse Effects at Predicted Environmental Relevant Concentrations On Nematodes in a Modified Chronic Toxicity Assay System. J Hazard Mater. 2012;243:161-8. PubMed PMID: 23127274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small sizes of TiO2-NPs exhibit adverse effects at predicted environmental relevant concentrations on nematodes in a modified chronic toxicity assay system. AU - Wu,Qiuli, AU - Wang,Wei, AU - Li,Yinxia, AU - Li,Yiping, AU - Ye,Boping, AU - Tang,Meng, AU - Wang,Dayong, Y1 - 2012/10/13/ PY - 2012/05/29/received PY - 2012/09/29/revised PY - 2012/10/07/accepted PY - 2012/11/7/entrez PY - 2012/11/7/pubmed PY - 2013/5/23/medline SP - 161 EP - 8 JF - Journal of hazardous materials JO - J Hazard Mater VL - 243 N2 - In Caenorhabditis elegans, although acute toxicity of TiO(2) nanoparticles (TiO(2)-NPs) at high concentrations has been investigated, we still know little about chronic toxicity of TiO(2)-NPs. Our data here showed that acute TiO(2)-NPs exposure in the range of μg/L had no obviously adverse effects on nematodes, but the chronic toxicities of large sizes (60 nm and 90 nm) of TiO(2)-NPs in the range of μg/L were detected in nematodes in a modified chronic toxicity assay system. Moreover, chronic toxicities of small sizes (4 nm and 10nm) of TiO(2)-NPs in the range of ng/L were observed in nematodes with locomotion behavior and ROS production as endpoints. In nematodes chronically exposed to small sizes of TiO(2)-NPs at predicted environmental relevant concentrations, locomotion behavior was significantly (P<0.01) correlated with ROS production. Furthermore, treatment with antioxidants (ascorbate and N-acetyl-l-cysteine) inhibited both the induction of ROS production and the decrease of locomotion behaviors observed in nematodes chronically exposed to small sizes of TiO(2)-NPs at predicted environmental relevant concentrations. Therefore, chronic exposure to small sizes of TiO(2)-NPs at predicted environmental relevant concentrations can cause adverse effects on nematodes, and formation of such adverse effects may be largely due to the induction of oxidative stress. SN - 1873-3336 UR - https://www.unboundmedicine.com/medline/citation/23127274/Small_sizes_of_TiO2_NPs_exhibit_adverse_effects_at_predicted_environmental_relevant_concentrations_on_nematodes_in_a_modified_chronic_toxicity_assay_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3894(12)01018-7 DB - PRIME DP - Unbound Medicine ER -
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