Tags

Type your tag names separated by a space and hit enter

Acetic-acid-mediated miscibility toward electrospinning homogeneous composite nanofibers of GT/PCL.
Biomacromolecules 2012; 13(12):3917-25B

Abstract

In tissue engineering research, there has recently been considerable interest in using electrospun biomimetic nanofibers of hybrids, in particular, from natural and synthetic polymers for engineering different tissues. However, phase separation between a pair of much dissimilar polymers might give rise to detrimental influences on both the electrospinning process and the resultant fiber performance. A representative natural-synthetic hybrid of gelatin (GT) and polycaprolactone (PCL) (50:50) was employed to study the phase separation behavior in electrospinning of the GT/PCL composite fibers. Using trifluoroethanol (TFE) as the cosolvent of the two polymers, observation of visible sedimentation and flocculation from dynamic light scattering analysis of the GT/PCL/TFE mixture both showed that phase separation does occur in just a few hours. This consequently led to gradually deteriorated fiber morphologies (e.g., splash, fiber bonding, and varied fiber size) over time during electrospinning GT/PCL. Quantitative analysis also indicated that the ratio of GT to PCL in the resultant GT/PCL fibers was altered over time. To address the phase separation related issues, a tiny amount (<0.3%) of acetic acid was introduced to improve the miscibility, which enabled the originally turbid solution to become clear immediately and to be single-phase stable for more than 1 week. Nanofibers thus obtained also appeared to be thinner, smooth, and homogeneous with enhanced performance in wettability and mechanical properties. Given the versatility and widely uses of the electrospun GT/PCL and other similar natural-synthetic hybrid systems in constructing tissue-engineered scaffolds, this work may offer a facile and effective approach to achieve finer and compositionally homogeneous hybrid nanofibers for effective applications.

Authors+Show Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials and College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23131188

Citation

Feng, Bei, et al. "Acetic-acid-mediated Miscibility Toward Electrospinning Homogeneous Composite Nanofibers of GT/PCL." Biomacromolecules, vol. 13, no. 12, 2012, pp. 3917-25.
Feng B, Tu H, Yuan H, et al. Acetic-acid-mediated miscibility toward electrospinning homogeneous composite nanofibers of GT/PCL. Biomacromolecules. 2012;13(12):3917-25.
Feng, B., Tu, H., Yuan, H., Peng, H., & Zhang, Y. (2012). Acetic-acid-mediated miscibility toward electrospinning homogeneous composite nanofibers of GT/PCL. Biomacromolecules, 13(12), pp. 3917-25. doi:10.1021/bm3009389.
Feng B, et al. Acetic-acid-mediated Miscibility Toward Electrospinning Homogeneous Composite Nanofibers of GT/PCL. Biomacromolecules. 2012 Dec 10;13(12):3917-25. PubMed PMID: 23131188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetic-acid-mediated miscibility toward electrospinning homogeneous composite nanofibers of GT/PCL. AU - Feng,Bei, AU - Tu,Hongbin, AU - Yuan,Huihua, AU - Peng,Hongju, AU - Zhang,Yanzhong, Y1 - 2012/11/14/ PY - 2012/11/8/entrez PY - 2012/11/8/pubmed PY - 2013/5/23/medline SP - 3917 EP - 25 JF - Biomacromolecules JO - Biomacromolecules VL - 13 IS - 12 N2 - In tissue engineering research, there has recently been considerable interest in using electrospun biomimetic nanofibers of hybrids, in particular, from natural and synthetic polymers for engineering different tissues. However, phase separation between a pair of much dissimilar polymers might give rise to detrimental influences on both the electrospinning process and the resultant fiber performance. A representative natural-synthetic hybrid of gelatin (GT) and polycaprolactone (PCL) (50:50) was employed to study the phase separation behavior in electrospinning of the GT/PCL composite fibers. Using trifluoroethanol (TFE) as the cosolvent of the two polymers, observation of visible sedimentation and flocculation from dynamic light scattering analysis of the GT/PCL/TFE mixture both showed that phase separation does occur in just a few hours. This consequently led to gradually deteriorated fiber morphologies (e.g., splash, fiber bonding, and varied fiber size) over time during electrospinning GT/PCL. Quantitative analysis also indicated that the ratio of GT to PCL in the resultant GT/PCL fibers was altered over time. To address the phase separation related issues, a tiny amount (<0.3%) of acetic acid was introduced to improve the miscibility, which enabled the originally turbid solution to become clear immediately and to be single-phase stable for more than 1 week. Nanofibers thus obtained also appeared to be thinner, smooth, and homogeneous with enhanced performance in wettability and mechanical properties. Given the versatility and widely uses of the electrospun GT/PCL and other similar natural-synthetic hybrid systems in constructing tissue-engineered scaffolds, this work may offer a facile and effective approach to achieve finer and compositionally homogeneous hybrid nanofibers for effective applications. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/23131188/Acetic_acid_mediated_miscibility_toward_electrospinning_homogeneous_composite_nanofibers_of_GT/PCL_ L2 - https://dx.doi.org/10.1021/bm3009389 DB - PRIME DP - Unbound Medicine ER -