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Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism.
Am J Hum Biol 2013 Jan-Feb; 25(1):101-6AJ

Abstract

OBJECTIVES

The relative length of the second-to-fourth digits (2D:4D) has been linked with prenatal androgen in humans. A recent study shows that the 2D:4D ratio in mice is controlled by the balance of androgen to estrogen signaling during a narrow window of digit development. Androgen receptor (AR) activity is higher in digit 4 than in digit 2, and inactivation of AR decreases growth of digit 4, which causes a higher 2D:4D ratio. At the molecular level, the effect of androgens is mediated through the activation of AR. The CAG/GGN repeat polymorphisms of the AR gene are associated with AR activity. Here, we investigate the effect of CAG/GGN repeat polymorphisms in AR on 2D:4D in Chinese.

METHODS

Digit lengths of the second and fourth fingers were measured from photocopies of the ventral surface of the hand and by actual finger measurements. We genotyped AR polymorphisms by ABI 3730 DNA analyzer.

RESULTS

We found that left hand 2D:4D ratio was longer than that of the right hand both in males and in females. We failed to find any relationship between CAG / GGN alleles and the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios (all, r < 0.20, P > 0.05).

CONCLUSIONS

In this study, we first found that the left hand 2D:4D ratio was longer than that of the right hand in both males and females. However, we found that both CAG and GGN alleles were not associated with the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios.

Authors+Show Affiliations

Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Yinchuan, Ningxia 750004, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23132707

Citation

Zhang, Chuan, et al. "Relationship of 2D:4D Finger Ratio With Androgen Receptor CAG and GGN Repeat Polymorphism." American Journal of Human Biology : the Official Journal of the Human Biology Council, vol. 25, no. 1, 2013, pp. 101-6.
Zhang C, Dang J, Pei L, et al. Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism. Am J Hum Biol. 2013;25(1):101-6.
Zhang, C., Dang, J., Pei, L., Guo, M., Zhu, H., Qu, L., ... Huo, Z. (2013). Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism. American Journal of Human Biology : the Official Journal of the Human Biology Council, 25(1), pp. 101-6. doi:10.1002/ajhb.22347.
Zhang C, et al. Relationship of 2D:4D Finger Ratio With Androgen Receptor CAG and GGN Repeat Polymorphism. Am J Hum Biol. 2013;25(1):101-6. PubMed PMID: 23132707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism. AU - Zhang,Chuan, AU - Dang,Jie, AU - Pei,Liguo, AU - Guo,Mengjing, AU - Zhu,Hao, AU - Qu,Lei, AU - Jia,Fei, AU - Lu,Hong, AU - Huo,Zhenghao, Y1 - 2012/11/07/ PY - 2012/09/05/received PY - 2012/10/14/accepted PY - 2012/11/8/entrez PY - 2012/11/8/pubmed PY - 2013/6/13/medline SP - 101 EP - 6 JF - American journal of human biology : the official journal of the Human Biology Council JO - Am. J. Hum. Biol. VL - 25 IS - 1 N2 - OBJECTIVES: The relative length of the second-to-fourth digits (2D:4D) has been linked with prenatal androgen in humans. A recent study shows that the 2D:4D ratio in mice is controlled by the balance of androgen to estrogen signaling during a narrow window of digit development. Androgen receptor (AR) activity is higher in digit 4 than in digit 2, and inactivation of AR decreases growth of digit 4, which causes a higher 2D:4D ratio. At the molecular level, the effect of androgens is mediated through the activation of AR. The CAG/GGN repeat polymorphisms of the AR gene are associated with AR activity. Here, we investigate the effect of CAG/GGN repeat polymorphisms in AR on 2D:4D in Chinese. METHODS: Digit lengths of the second and fourth fingers were measured from photocopies of the ventral surface of the hand and by actual finger measurements. We genotyped AR polymorphisms by ABI 3730 DNA analyzer. RESULTS: We found that left hand 2D:4D ratio was longer than that of the right hand both in males and in females. We failed to find any relationship between CAG / GGN alleles and the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios (all, r < 0.20, P > 0.05). CONCLUSIONS: In this study, we first found that the left hand 2D:4D ratio was longer than that of the right hand in both males and females. However, we found that both CAG and GGN alleles were not associated with the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios. SN - 1520-6300 UR - https://www.unboundmedicine.com/medline/citation/23132707/Relationship_of_2D:4D_finger_ratio_with_androgen_receptor_CAG_and_GGN_repeat_polymorphism_ L2 - https://doi.org/10.1002/ajhb.22347 DB - PRIME DP - Unbound Medicine ER -