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Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmö Diet and Cancer cohort.
Am J Clin Nutr. 2012 Dec; 96(6):1409-18.AJ

Abstract

BACKGROUND

Dietary carbohydrates have been implicated in relation to prostate cancer.

OBJECTIVE

Our objective was to examine the associations between dietary intakes of carbohydrates, fiber, and their food sources and risk of prostate cancer, overall and by case severity, in the Malmö Diet and Cancer cohort.

DESIGN

The analysis included 8128 men aged 45-73 y without a history of cancer, cardiovascular disease, or diabetes and who were classified as adequate energy reporters. After a median follow-up time of 15 y, prostate cancer was diagnosed in 817 men. We used Cox proportional hazards regression to model associations between energy-adjusted nutrient and food intakes with risk of incident prostate cancer, with competing risk of death from non-prostate cancer causes taken into account.

RESULTS

After adjustment for age and other known or potential risk factors, we observed no associations between total carbohydrates or dietary fiber and prostate cancer. We observed positive associations between the intake of low-fiber cereals with overall and low-risk prostate cancer and between intakes of cake and biscuits and rice and pasta with low-risk prostate cancer (all P-trend < 0.05). A high intake compared with zero consumption of sugar-sweetened beverages was associated with increased risk of symptomatic prostate cancer (HR: 1.38; 95% CI: 1.04, 1.84).

CONCLUSIONS

Results from this large study with high-validity dietary data suggest that a high intake of refined carbohydrates may be associated with increased risk of prostate cancer. However we observed no significant associations with high-risk prostate cancer, and not all foods that are typically high in refined carbohydrates were associated with prostate cancer.

Authors+Show Affiliations

Research Group in Nutritional Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden. isabel.drake@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23134882

Citation

Drake, Isabel, et al. "Dietary Intakes of Carbohydrates in Relation to Prostate Cancer Risk: a Prospective Study in the Malmö Diet and Cancer Cohort." The American Journal of Clinical Nutrition, vol. 96, no. 6, 2012, pp. 1409-18.
Drake I, Sonestedt E, Gullberg B, et al. Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmö Diet and Cancer cohort. Am J Clin Nutr. 2012;96(6):1409-18.
Drake, I., Sonestedt, E., Gullberg, B., Ahlgren, G., Bjartell, A., Wallström, P., & Wirfält, E. (2012). Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmö Diet and Cancer cohort. The American Journal of Clinical Nutrition, 96(6), 1409-18. https://doi.org/10.3945/ajcn.112.039438
Drake I, et al. Dietary Intakes of Carbohydrates in Relation to Prostate Cancer Risk: a Prospective Study in the Malmö Diet and Cancer Cohort. Am J Clin Nutr. 2012;96(6):1409-18. PubMed PMID: 23134882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmö Diet and Cancer cohort. AU - Drake,Isabel, AU - Sonestedt,Emily, AU - Gullberg,Bo, AU - Ahlgren,Göran, AU - Bjartell,Anders, AU - Wallström,Peter, AU - Wirfält,Elisabet, Y1 - 2012/11/07/ PY - 2012/11/9/entrez PY - 2012/11/9/pubmed PY - 2013/1/26/medline SP - 1409 EP - 18 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 6 N2 - BACKGROUND: Dietary carbohydrates have been implicated in relation to prostate cancer. OBJECTIVE: Our objective was to examine the associations between dietary intakes of carbohydrates, fiber, and their food sources and risk of prostate cancer, overall and by case severity, in the Malmö Diet and Cancer cohort. DESIGN: The analysis included 8128 men aged 45-73 y without a history of cancer, cardiovascular disease, or diabetes and who were classified as adequate energy reporters. After a median follow-up time of 15 y, prostate cancer was diagnosed in 817 men. We used Cox proportional hazards regression to model associations between energy-adjusted nutrient and food intakes with risk of incident prostate cancer, with competing risk of death from non-prostate cancer causes taken into account. RESULTS: After adjustment for age and other known or potential risk factors, we observed no associations between total carbohydrates or dietary fiber and prostate cancer. We observed positive associations between the intake of low-fiber cereals with overall and low-risk prostate cancer and between intakes of cake and biscuits and rice and pasta with low-risk prostate cancer (all P-trend < 0.05). A high intake compared with zero consumption of sugar-sweetened beverages was associated with increased risk of symptomatic prostate cancer (HR: 1.38; 95% CI: 1.04, 1.84). CONCLUSIONS: Results from this large study with high-validity dietary data suggest that a high intake of refined carbohydrates may be associated with increased risk of prostate cancer. However we observed no significant associations with high-risk prostate cancer, and not all foods that are typically high in refined carbohydrates were associated with prostate cancer. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23134882/Dietary_intakes_of_carbohydrates_in_relation_to_prostate_cancer_risk:_a_prospective_study_in_the_Malmö_Diet_and_Cancer_cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.039438 DB - PRIME DP - Unbound Medicine ER -