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Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study.
Am J Clin Nutr 2012; 96(6):1362-8AJ

Abstract

BACKGROUND

There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.

OBJECTIVE

We investigated the independent associations of homocysteine, folate, and vitamin B-12 with gait and balance performance and Instrumental Activities of Daily Living (IADL) in community-living older persons.

DESIGN

We performed cross-sectional analyses on baseline data of 796 respondents in the Singapore Longitudinal Ageing Study who had laboratory measurements of fasting homocysteine folate and vitamin B-12 and completed Performance Oriented Mobility Assessment (POMA) of gait and balance and self-reports of IADLs.

RESULTS

In multivariate analyses in which sex, age, education, housing type, comorbidities, hospitalization, depression and global cognitive scores, BMI, creatinine, arthritis and hip fracture, serum albumin and hemoglobin, and physical activities were controlled for, we showed that homocysteine, independently of folate and vitamin B-12, showed significant negative associations with POMA balance (P = 0.02), POMA gait scores (P < 0.01), and IADL (P < 0.01). Serum folate showed a significant positive association only with POMA balance scores (P < 0.045). No significant independent associations for vitamin B-12 were observed.

CONCLUSIONS

The independent association of elevated homocysteine and low folate, but not vitamin B-12, on physical and functional decline was supported in this study. Interventional studies of the physical functional effects of folate and vitamin B-12 status in different populations are needed.

Authors+Show Affiliations

Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. pcmngtp@nus.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23134883

Citation

Ng, Tze-Pin, et al. "Homocysteine, Folate, Vitamin B-12, and Physical Function in Older Adults: Cross-sectional Findings From the Singapore Longitudinal Ageing Study." The American Journal of Clinical Nutrition, vol. 96, no. 6, 2012, pp. 1362-8.
Ng TP, Aung KC, Feng L, et al. Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study. Am J Clin Nutr. 2012;96(6):1362-8.
Ng, T. P., Aung, K. C., Feng, L., Scherer, S. C., & Yap, K. B. (2012). Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study. The American Journal of Clinical Nutrition, 96(6), pp. 1362-8. doi:10.3945/ajcn.112.035741.
Ng TP, et al. Homocysteine, Folate, Vitamin B-12, and Physical Function in Older Adults: Cross-sectional Findings From the Singapore Longitudinal Ageing Study. Am J Clin Nutr. 2012;96(6):1362-8. PubMed PMID: 23134883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study. AU - Ng,Tze-Pin, AU - Aung,Khin Chaw Yu, AU - Feng,Lei, AU - Scherer,Samuel C, AU - Yap,Keng Bee, Y1 - 2012/11/07/ PY - 2012/11/9/entrez PY - 2012/11/9/pubmed PY - 2013/1/26/medline SP - 1362 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 6 N2 - BACKGROUND: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons. OBJECTIVE: We investigated the independent associations of homocysteine, folate, and vitamin B-12 with gait and balance performance and Instrumental Activities of Daily Living (IADL) in community-living older persons. DESIGN: We performed cross-sectional analyses on baseline data of 796 respondents in the Singapore Longitudinal Ageing Study who had laboratory measurements of fasting homocysteine folate and vitamin B-12 and completed Performance Oriented Mobility Assessment (POMA) of gait and balance and self-reports of IADLs. RESULTS: In multivariate analyses in which sex, age, education, housing type, comorbidities, hospitalization, depression and global cognitive scores, BMI, creatinine, arthritis and hip fracture, serum albumin and hemoglobin, and physical activities were controlled for, we showed that homocysteine, independently of folate and vitamin B-12, showed significant negative associations with POMA balance (P = 0.02), POMA gait scores (P < 0.01), and IADL (P < 0.01). Serum folate showed a significant positive association only with POMA balance scores (P < 0.045). No significant independent associations for vitamin B-12 were observed. CONCLUSIONS: The independent association of elevated homocysteine and low folate, but not vitamin B-12, on physical and functional decline was supported in this study. Interventional studies of the physical functional effects of folate and vitamin B-12 status in different populations are needed. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23134883/Homocysteine_folate_vitamin_B_12_and_physical_function_in_older_adults:_cross_sectional_findings_from_the_Singapore_Longitudinal_Ageing_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.035741 DB - PRIME DP - Unbound Medicine ER -