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Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study.
J Drugs Dermatol. 2012 Nov; 11(11):e70-3.JD

Abstract

BACKGROUND AND OBJECTIVE

Many tinea inguinalis infections are characterized by pronounced inflammatory lesions and pruritus. Therefore, a therapy with a topical corticosteroid in addition to a topical antimycotic agent might be beneficial. In this multicenter, retrospective study, we compared the mycological and clinical efficacy and tolerability of isoconazole nitrate alone vs isoconazole nitrate and diflucortolone valerate in 58 adult patients with tinea inguinalis.

PATIENTS AND METHODS

Treatment duration was three weeks. The efficacy of the treatment was based on the assessment of several signs and symptoms, which were collected on a 4-point scale. All patients were examined clinically before the beginning of the treatment, one week later, two weeks later, and at the end of the treatment. Mycological examinations were performed before the beginning of the treatment and at the end of the study.

RESULTS

Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus. Both erythema and pruritus resolved in a larger percentage of patients and more quickly. Both regimens were well tolerated. Mycological cure rates were similar in both groups of patients.

CONCLUSIONS

Combination therapy with isoconazole nitrate and diflucortolone valerate is an effective and well-tolerated regimen in adult patients with tinea inguinalis.

Authors+Show Affiliations

Department of Anesthesiology, Intensive Care and Dermatological Sciences, Università degli Studi di Milano, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, Milan, Italy. stefano.veraldi@unimi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

23135097

Citation

Veraldi, Stefano, et al. "Isoconazole Nitrate Vs Isoconazole Nitrate and Diflucortolone Valerate in the Treatment of Tinea Inguinalis: Results of a Multicenter Retrospective Study." Journal of Drugs in Dermatology : JDD, vol. 11, no. 11, 2012, pp. e70-3.
Veraldi S, Persico MC, Schianchi R. Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study. J Drugs Dermatol. 2012;11(11):e70-3.
Veraldi, S., Persico, M. C., & Schianchi, R. (2012). Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study. Journal of Drugs in Dermatology : JDD, 11(11), e70-3.
Veraldi S, Persico MC, Schianchi R. Isoconazole Nitrate Vs Isoconazole Nitrate and Diflucortolone Valerate in the Treatment of Tinea Inguinalis: Results of a Multicenter Retrospective Study. J Drugs Dermatol. 2012;11(11):e70-3. PubMed PMID: 23135097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study. AU - Veraldi,Stefano, AU - Persico,Maria Chiara, AU - Schianchi,Rossana, PY - 2012/11/9/entrez PY - 2012/11/9/pubmed PY - 2013/5/2/medline SP - e70 EP - 3 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 11 IS - 11 N2 - BACKGROUND AND OBJECTIVE: Many tinea inguinalis infections are characterized by pronounced inflammatory lesions and pruritus. Therefore, a therapy with a topical corticosteroid in addition to a topical antimycotic agent might be beneficial. In this multicenter, retrospective study, we compared the mycological and clinical efficacy and tolerability of isoconazole nitrate alone vs isoconazole nitrate and diflucortolone valerate in 58 adult patients with tinea inguinalis. PATIENTS AND METHODS: Treatment duration was three weeks. The efficacy of the treatment was based on the assessment of several signs and symptoms, which were collected on a 4-point scale. All patients were examined clinically before the beginning of the treatment, one week later, two weeks later, and at the end of the treatment. Mycological examinations were performed before the beginning of the treatment and at the end of the study. RESULTS: Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus. Both erythema and pruritus resolved in a larger percentage of patients and more quickly. Both regimens were well tolerated. Mycological cure rates were similar in both groups of patients. CONCLUSIONS: Combination therapy with isoconazole nitrate and diflucortolone valerate is an effective and well-tolerated regimen in adult patients with tinea inguinalis. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/23135097/Isoconazole_nitrate_vs_isoconazole_nitrate_and_diflucortolone_valerate_in_the_treatment_of_tinea_inguinalis:_results_of_a_multicenter_retrospective_study_ L2 - http://jddonline.com/articles/dermatology/S1545961612E0070X DB - PRIME DP - Unbound Medicine ER -