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[Changes in titin and myosin heavy chain isoform composition in skeletal muscles of Mongolian gerbil (Meriones unguiculatus) after 12-day spaceflight].

Abstract

Changes of titin and myosin heavy chain isoform composition in skeletal muscles (m. soleus, m. gastrocnemius, m. tibialis anterior, m. psoas major) in Mongolian Gerbil (Meriones unguiculatus ) were investigated after 12-day spaceflight on board of Russian space vehicle "Foton-M3". In m. psoas and m. soleus in the gerbils from "Flight" group the expected increase in the content of fast myosin heavy chain isoforms (IIxd and IIa, respectively) were observed. No significant differences were found in the content of IIxd and IIa isoforms of myosin heavy chain in m. tibialis anterior in the gerbils from control group as compared to that in "Flight" group. An unexpected increase in the content of slow myosin heavy chain I isoform and a decrease in the content of fast IIx/d isoform in m. gastrocnemius of the gerbils from "Flight" group were observed. In skeletal muscles of the gerbils from "Flight" group the relative content of titin N2A-isoform was reduced (by 1,2-1,7 times), although the content of its NT-isoform, which was revealed in striated muscles of mammals in our experiments earlier, remained the same. When the content of titin N2A-isoform was decreased, no predictable abnormalities in sarcomeric structure and contractile ability of skeletal muscles in the gerbils from "Flight" group were found. An assumption on the leading role of titin NT-isoform in maintenance of structural and functional properties of striated muscles of mammals was made.

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Authors

, , , , , ,

Source

Biofizika 57:5 pg 756-63

MeSH

Animals
Connectin
Gerbillinae
Humans
Muscle Contraction
Muscle Fibers, Fast-Twitch
Muscle Fibers, Slow-Twitch
Muscle Proteins
Muscle, Skeletal
Myosin Heavy Chains
Protein Isoforms
Protein Kinases
Psoas Muscles
Space Flight
Weightlessness

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

rus

PubMed ID

23136767

Citation

Okuneva, A D., et al. "[Changes in Titin and Myosin Heavy Chain Isoform Composition in Skeletal Muscles of Mongolian Gerbil (Meriones Unguiculatus) After 12-day Spaceflight]." Biofizika, vol. 57, no. 5, 2012, pp. 756-63.
Okuneva AD, Vikhliantsev IM, Shpagina MD, et al. [Changes in titin and myosin heavy chain isoform composition in skeletal muscles of Mongolian gerbil (Meriones unguiculatus) after 12-day spaceflight]. Biofizika. 2012;57(5):756-63.
Okuneva, A. D., Vikhliantsev, I. M., Shpagina, M. D., Rogachevskiĭ, V. V., Khutsian, S. S., Poddubnaia, Z. A., & Grigor'ev, A. I. (2012). [Changes in titin and myosin heavy chain isoform composition in skeletal muscles of Mongolian gerbil (Meriones unguiculatus) after 12-day spaceflight]. Biofizika, 57(5), pp. 756-63.
Okuneva AD, et al. [Changes in Titin and Myosin Heavy Chain Isoform Composition in Skeletal Muscles of Mongolian Gerbil (Meriones Unguiculatus) After 12-day Spaceflight]. Biofizika. 2012;57(5):756-63. PubMed PMID: 23136767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes in titin and myosin heavy chain isoform composition in skeletal muscles of Mongolian gerbil (Meriones unguiculatus) after 12-day spaceflight]. AU - Okuneva,A D, AU - Vikhliantsev,I M, AU - Shpagina,M D, AU - Rogachevskiĭ,V V, AU - Khutsian,S S, AU - Poddubnaia,Z A, AU - Grigor'ev,A I, PY - 2012/11/10/entrez PY - 2012/11/10/pubmed PY - 2012/12/10/medline SP - 756 EP - 63 JF - Biofizika JO - Biofizika VL - 57 IS - 5 N2 - Changes of titin and myosin heavy chain isoform composition in skeletal muscles (m. soleus, m. gastrocnemius, m. tibialis anterior, m. psoas major) in Mongolian Gerbil (Meriones unguiculatus ) were investigated after 12-day spaceflight on board of Russian space vehicle "Foton-M3". In m. psoas and m. soleus in the gerbils from "Flight" group the expected increase in the content of fast myosin heavy chain isoforms (IIxd and IIa, respectively) were observed. No significant differences were found in the content of IIxd and IIa isoforms of myosin heavy chain in m. tibialis anterior in the gerbils from control group as compared to that in "Flight" group. An unexpected increase in the content of slow myosin heavy chain I isoform and a decrease in the content of fast IIx/d isoform in m. gastrocnemius of the gerbils from "Flight" group were observed. In skeletal muscles of the gerbils from "Flight" group the relative content of titin N2A-isoform was reduced (by 1,2-1,7 times), although the content of its NT-isoform, which was revealed in striated muscles of mammals in our experiments earlier, remained the same. When the content of titin N2A-isoform was decreased, no predictable abnormalities in sarcomeric structure and contractile ability of skeletal muscles in the gerbils from "Flight" group were found. An assumption on the leading role of titin NT-isoform in maintenance of structural and functional properties of striated muscles of mammals was made. SN - 0006-3029 UR - https://www.unboundmedicine.com/medline/citation/23136767/[Changes_in_titin_and_myosin_heavy_chain_isoform_composition_in_skeletal_muscles_of_Mongolian_gerbil__Meriones_unguiculatus__after_12_day_spaceflight]_ DB - PRIME DP - Unbound Medicine ER -