Tags

Type your tag names separated by a space and hit enter

Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort.
Nutr Cancer 2012; 64(8):1131-42NC

Abstract

Studies of dietary fat intake and breast cancer have been inconsistent and few have examined specific fatty acids. We examined the association between specific monounsaturated (MUFA), polyunsaturated (PUFA), saturated (SFA), and trans-fatty acids (TFA) and breast cancer risk. Participants, 50-76 yr, were female members of the VITamins And Lifestyle (VITAL) Cohort, who were postmenopausal at baseline. In 2000-2002, participants completed a food frequency questionnaire. Seven hundred seventy-two incident, primary breast cancer cases were identified using a population-based cancer registry. Cox proportional hazard models estimated hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between fatty acid intake and breast cancer risk. Intake of total MUFAs (highest vs. lowest quintile: HR = 1.61, 95% CI: 1.08-2.38, P trend = 0.02), particularly myristoleic and erucic acids, was associated with increased breast cancer risk. Whereas total SFA was suggestive of an increased risk (HR = 1.47, 95% CI: 1.00-2.15, P trend = 0.09), strong associations were observed for palmitic, margaric, and stearic acids. Total TFA and PUFA intake were not associated with breast cancer. However, among TFAs, linolelaidic acid was positively associated with risk; among PUFAs, intake of eicosapentaenoic and docosahexaenoic acids were inversely associated with risk. Our findings show that fatty acids are heterogeneous in their association with postmenopausal breast cancer risk.

Authors+Show Affiliations

The Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Washington 98109-1024, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23137008

Citation

Sczaniecka, Anna K., et al. "Dietary Intake of Specific Fatty Acids and Breast Cancer Risk Among Postmenopausal Women in the VITAL Cohort." Nutrition and Cancer, vol. 64, no. 8, 2012, pp. 1131-42.
Sczaniecka AK, Brasky TM, Lampe JW, et al. Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort. Nutr Cancer. 2012;64(8):1131-42.
Sczaniecka, A. K., Brasky, T. M., Lampe, J. W., Patterson, R. E., & White, E. (2012). Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort. Nutrition and Cancer, 64(8), pp. 1131-42. doi:10.1080/01635581.2012.718033.
Sczaniecka AK, et al. Dietary Intake of Specific Fatty Acids and Breast Cancer Risk Among Postmenopausal Women in the VITAL Cohort. Nutr Cancer. 2012;64(8):1131-42. PubMed PMID: 23137008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort. AU - Sczaniecka,Anna K, AU - Brasky,Theodore M, AU - Lampe,Johanna W, AU - Patterson,Ruth E, AU - White,Emily, Y1 - 2012/11/08/ PY - 2012/11/10/entrez PY - 2012/11/10/pubmed PY - 2013/5/4/medline SP - 1131 EP - 42 JF - Nutrition and cancer JO - Nutr Cancer VL - 64 IS - 8 N2 - Studies of dietary fat intake and breast cancer have been inconsistent and few have examined specific fatty acids. We examined the association between specific monounsaturated (MUFA), polyunsaturated (PUFA), saturated (SFA), and trans-fatty acids (TFA) and breast cancer risk. Participants, 50-76 yr, were female members of the VITamins And Lifestyle (VITAL) Cohort, who were postmenopausal at baseline. In 2000-2002, participants completed a food frequency questionnaire. Seven hundred seventy-two incident, primary breast cancer cases were identified using a population-based cancer registry. Cox proportional hazard models estimated hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between fatty acid intake and breast cancer risk. Intake of total MUFAs (highest vs. lowest quintile: HR = 1.61, 95% CI: 1.08-2.38, P trend = 0.02), particularly myristoleic and erucic acids, was associated with increased breast cancer risk. Whereas total SFA was suggestive of an increased risk (HR = 1.47, 95% CI: 1.00-2.15, P trend = 0.09), strong associations were observed for palmitic, margaric, and stearic acids. Total TFA and PUFA intake were not associated with breast cancer. However, among TFAs, linolelaidic acid was positively associated with risk; among PUFAs, intake of eicosapentaenoic and docosahexaenoic acids were inversely associated with risk. Our findings show that fatty acids are heterogeneous in their association with postmenopausal breast cancer risk. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/23137008/Dietary_intake_of_specific_fatty_acids_and_breast_cancer_risk_among_postmenopausal_women_in_the_VITAL_cohort_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2012.718033 DB - PRIME DP - Unbound Medicine ER -