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Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI.
Psychiatry Res 2012; 204(2-3):168-77PR

Abstract

Nicotine can have beneficial effects on attention performance and corresponding brain function in both schizophrenia patients and healthy controls, but it remains controversial whether nicotine affects brain function differentially in patients vs. controls. The effects of nicotine on brain activity elicited by attention-requiring oddball-type tasks have not been studied in schizophrenia patients. In this study we sought to investigate the impact of nicotine on the p300 evoked potential component and corresponding fMRI (functional magnetic resonance imaging) activation measures in schizophrenia patients and controls. Applying a double-blind, placebo-controlled cross-over design, the effects of 1mg nasal nicotine on brain activity elicited by a visual oddball-type task in N=14 schizophrenia and N=15 control smokers were studied with simultaneous EEG-fMRI. EEG single trial amplitudes were used to inform the fMRI analysis. We found a nicotine-associated increase in P300-informed fMRI activation in schizophrenia patients and controls, mainly in the anterior cingulate and adjacent medial frontal cortex. No group differences in the response to nicotine were found. Remarkably, averaged EEG and fMRI activation measures considered in isolation were largely unaffected by nicotine. Taken together, the effects of nicotine on P300 amplitude-associated brain activation do not seem to be fundamentally different in schizophrenic smokers and healthy controls.

Authors+Show Affiliations

Institute of Neuroscience & Medicine, Research Center Jülich, Germany. Arian.Mobascher@unimedizin-mainz.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23137805

Citation

Mobascher, Arian, et al. "Nicotine Effects On Anterior Cingulate Cortex in Schizophrenia and Healthy Smokers as Revealed By EEG-informed FMRI." Psychiatry Research, vol. 204, no. 2-3, 2012, pp. 168-77.
Mobascher A, Warbrick T, Brinkmeyer J, et al. Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI. Psychiatry Res. 2012;204(2-3):168-77.
Mobascher, A., Warbrick, T., Brinkmeyer, J., Musso, F., Stoecker, T., Jon Shah, N., & Winterer, G. (2012). Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI. Psychiatry Research, 204(2-3), pp. 168-77. doi:10.1016/j.pscychresns.2012.09.005.
Mobascher A, et al. Nicotine Effects On Anterior Cingulate Cortex in Schizophrenia and Healthy Smokers as Revealed By EEG-informed FMRI. Psychiatry Res. 2012 Nov 30;204(2-3):168-77. PubMed PMID: 23137805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI. AU - Mobascher,Arian, AU - Warbrick,Tracy, AU - Brinkmeyer,Juergen, AU - Musso,Francesco, AU - Stoecker,Tony, AU - Jon Shah,N, AU - Winterer,Georg, Y1 - 2012/11/06/ PY - 2012/05/30/received PY - 2012/08/15/revised PY - 2012/09/19/accepted PY - 2012/11/10/entrez PY - 2012/11/10/pubmed PY - 2013/6/1/medline SP - 168 EP - 77 JF - Psychiatry research JO - Psychiatry Res VL - 204 IS - 2-3 N2 - Nicotine can have beneficial effects on attention performance and corresponding brain function in both schizophrenia patients and healthy controls, but it remains controversial whether nicotine affects brain function differentially in patients vs. controls. The effects of nicotine on brain activity elicited by attention-requiring oddball-type tasks have not been studied in schizophrenia patients. In this study we sought to investigate the impact of nicotine on the p300 evoked potential component and corresponding fMRI (functional magnetic resonance imaging) activation measures in schizophrenia patients and controls. Applying a double-blind, placebo-controlled cross-over design, the effects of 1mg nasal nicotine on brain activity elicited by a visual oddball-type task in N=14 schizophrenia and N=15 control smokers were studied with simultaneous EEG-fMRI. EEG single trial amplitudes were used to inform the fMRI analysis. We found a nicotine-associated increase in P300-informed fMRI activation in schizophrenia patients and controls, mainly in the anterior cingulate and adjacent medial frontal cortex. No group differences in the response to nicotine were found. Remarkably, averaged EEG and fMRI activation measures considered in isolation were largely unaffected by nicotine. Taken together, the effects of nicotine on P300 amplitude-associated brain activation do not seem to be fundamentally different in schizophrenic smokers and healthy controls. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/23137805/Nicotine_effects_on_anterior_cingulate_cortex_in_schizophrenia_and_healthy_smokers_as_revealed_by_EEG_informed_fMRI_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(12)00218-1 DB - PRIME DP - Unbound Medicine ER -