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Effects of zinc supplementation on antioxidant status and lipid peroxidation in hemodialysis patients.
J Ren Nutr. 2013 May; 23(3):180-4.JR

Abstract

OBJECTIVES

This study was designed to determine the effects of zinc supplementation on oxidative stress in hemodialysis (HD) patients through evaluating total antioxidant capacity (TAC), whole blood glutathione peroxidase (GSH) level, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) level.

DESIGN AND SETTING

Double-blinded randomized controlled trialfrom October 2006 to December 2007 at Tabriz Imam Khomeini Hospital.

SUBJECTS

Sixty-five HD patients were randomly enrolled into 2 groups.

INTERVENTION

Patients received placebo in group A and zinc (100 mg/day) in group B for 2 months. After a washout period for 2 months, the groups were crossed over and the study was continued for an additional 2 months.

MAIN OUTCOME MEASURES

Serum zinc concentration was measured using atomic absorption spectrophotometry. TAC, GSH level, and SOD activity were determined by commercial enzyme-linked immunosorbent assay kits. MDA level was measured using a thiobarbituric acid method.

RESULTS

The levels of serum zinc, TAC, GSH (P < .001 for all), and SOD activity (P < .001 for group A and P = .003 for group B) significantly increased after zinc supplementation whereas the serum level of MDA decreased after the same period (P = .003 for group A and P < .001 for group B).

CONCLUSIONS

Zinc supplementation for 2 months improved the serum levels of zinc, antioxidant status, and lipid peroxidation in HD patients.

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Authors+Show Affiliations

Mazani M
Department of Biochemistry, Ardabil University of Medical Science, Ardabil, Iran.
Argani H
No affiliation info available
Rashtchizadeh N
No affiliation info available
Ghorbanihaghjo A
No affiliation info available
Hamdi A
No affiliation info available
Estiar MA
No affiliation info available
Nezami N
No affiliation info available

MeSH

AdultAgedAntioxidantsBody Mass IndexCross-Over StudiesDietary SupplementsDouble-Blind MethodEnzyme-Linked Immunosorbent AssayFemaleGlutathione PeroxidaseHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxidative StressRenal DialysisSpectrophotometry, AtomicSuperoxide DismutaseZinc

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23140661

Citation

Mazani, Mohammad, et al. "Effects of Zinc Supplementation On Antioxidant Status and Lipid Peroxidation in Hemodialysis Patients." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 23, no. 3, 2013, pp. 180-4.
Mazani M, Argani H, Rashtchizadeh N, et al. Effects of zinc supplementation on antioxidant status and lipid peroxidation in hemodialysis patients. J Ren Nutr. 2013;23(3):180-4.
Mazani, M., Argani, H., Rashtchizadeh, N., Ghorbanihaghjo, A., Hamdi, A., Estiar, M. A., & Nezami, N. (2013). Effects of zinc supplementation on antioxidant status and lipid peroxidation in hemodialysis patients. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 23(3), 180-4. https://doi.org/10.1053/j.jrn.2012.08.012
Mazani M, et al. Effects of Zinc Supplementation On Antioxidant Status and Lipid Peroxidation in Hemodialysis Patients. J Ren Nutr. 2013;23(3):180-4. PubMed PMID: 23140661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of zinc supplementation on antioxidant status and lipid peroxidation in hemodialysis patients. AU - Mazani,Mohammad, AU - Argani,Hassan, AU - Rashtchizadeh,Nadereh, AU - Ghorbanihaghjo,Amir, AU - Hamdi,Amir, AU - Estiar,Mehrdad Asghari, AU - Nezami,Nariman, Y1 - 2012/11/07/ PY - 2012/03/16/received PY - 2012/08/18/revised PY - 2012/08/31/accepted PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2014/1/5/medline SP - 180 EP - 4 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 23 IS - 3 N2 - OBJECTIVES: This study was designed to determine the effects of zinc supplementation on oxidative stress in hemodialysis (HD) patients through evaluating total antioxidant capacity (TAC), whole blood glutathione peroxidase (GSH) level, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) level. DESIGN AND SETTING: Double-blinded randomized controlled trialfrom October 2006 to December 2007 at Tabriz Imam Khomeini Hospital. SUBJECTS: Sixty-five HD patients were randomly enrolled into 2 groups. INTERVENTION: Patients received placebo in group A and zinc (100 mg/day) in group B for 2 months. After a washout period for 2 months, the groups were crossed over and the study was continued for an additional 2 months. MAIN OUTCOME MEASURES: Serum zinc concentration was measured using atomic absorption spectrophotometry. TAC, GSH level, and SOD activity were determined by commercial enzyme-linked immunosorbent assay kits. MDA level was measured using a thiobarbituric acid method. RESULTS: The levels of serum zinc, TAC, GSH (P < .001 for all), and SOD activity (P < .001 for group A and P = .003 for group B) significantly increased after zinc supplementation whereas the serum level of MDA decreased after the same period (P = .003 for group A and P < .001 for group B). CONCLUSIONS: Zinc supplementation for 2 months improved the serum levels of zinc, antioxidant status, and lipid peroxidation in HD patients. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/23140661/Effects_of_zinc_supplementation_on_antioxidant_status_and_lipid_peroxidation_in_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(12)00179-3 DB - PRIME DP - Unbound Medicine ER -