Tags

Type your tag names separated by a space and hit enter

Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia.
Exp Neurol. 2013 Feb; 240:64-74.EN

Abstract

Idiopathic focal hand dystonia (FHD) arises from abnormal plasticity in the primary motor cortex (M1) possibly reflecting abnormal sensori-motor integration processes. In this transcranial magnetic stimulation (TMS) study in FHD, we evaluated changes in motor evoked potentials (MEPs) after intermittent theta burst stimulation (iTBS) and paired associative stimulation (PAS), techniques that elicit different forms of experimentally-induced long-term potentiation (LTP)-like plasticity in M1. We also examined behaviorally-induced LTP-like plasticity as reflected by early motor learning of a simple motor task. We studied 14 patients with FHD and 14 healthy subjects. MEPs were recorded before and after iTBS and PAS at the 25 ms interstimulus interval (PAS(25)) in separate sessions. Subjects did a simple motor task entailing repetitive index finger abductions. To measure early motor learning we tested practice-related improvement in peak velocity and peak acceleration. In FHD patients iTBS failed to elicit the expected MEP changes and PAS(25) induced abnormally increased MEPs in target and non-target muscles. In the experiment testing early motor learning, patients lacked the expected practice-related changes in kinematic variables. In FHD, the degree of early motor learning correlated with patients' clinical features. We conclude that experimentally-induced (iTBS and PAS) and behaviorally-induced LTP-like plasticity are both altered in FHD.

Authors+Show Affiliations

Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23142185

Citation

Belvisi, Daniele, et al. "Abnormal Experimentally- and Behaviorally-induced LTP-like Plasticity in Focal Hand Dystonia." Experimental Neurology, vol. 240, 2013, pp. 64-74.
Belvisi D, Suppa A, Marsili L, et al. Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. Exp Neurol. 2013;240:64-74.
Belvisi, D., Suppa, A., Marsili, L., Di Stasio, F., Parvez, A. K., Agostino, R., Fabbrini, G., & Berardelli, A. (2013). Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. Experimental Neurology, 240, 64-74. https://doi.org/10.1016/j.expneurol.2012.11.003
Belvisi D, et al. Abnormal Experimentally- and Behaviorally-induced LTP-like Plasticity in Focal Hand Dystonia. Exp Neurol. 2013;240:64-74. PubMed PMID: 23142185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. AU - Belvisi,Daniele, AU - Suppa,Antonio, AU - Marsili,Luca, AU - Di Stasio,Flavio, AU - Parvez,Ahmad Khandker, AU - Agostino,Rocco, AU - Fabbrini,Giovanni, AU - Berardelli,Alfredo, Y1 - 2012/11/08/ PY - 2012/08/05/received PY - 2012/10/04/revised PY - 2012/11/02/accepted PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2013/3/26/medline SP - 64 EP - 74 JF - Experimental neurology JO - Exp. Neurol. VL - 240 N2 - Idiopathic focal hand dystonia (FHD) arises from abnormal plasticity in the primary motor cortex (M1) possibly reflecting abnormal sensori-motor integration processes. In this transcranial magnetic stimulation (TMS) study in FHD, we evaluated changes in motor evoked potentials (MEPs) after intermittent theta burst stimulation (iTBS) and paired associative stimulation (PAS), techniques that elicit different forms of experimentally-induced long-term potentiation (LTP)-like plasticity in M1. We also examined behaviorally-induced LTP-like plasticity as reflected by early motor learning of a simple motor task. We studied 14 patients with FHD and 14 healthy subjects. MEPs were recorded before and after iTBS and PAS at the 25 ms interstimulus interval (PAS(25)) in separate sessions. Subjects did a simple motor task entailing repetitive index finger abductions. To measure early motor learning we tested practice-related improvement in peak velocity and peak acceleration. In FHD patients iTBS failed to elicit the expected MEP changes and PAS(25) induced abnormally increased MEPs in target and non-target muscles. In the experiment testing early motor learning, patients lacked the expected practice-related changes in kinematic variables. In FHD, the degree of early motor learning correlated with patients' clinical features. We conclude that experimentally-induced (iTBS and PAS) and behaviorally-induced LTP-like plasticity are both altered in FHD. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/23142185/Abnormal_experimentally__and_behaviorally_induced_LTP_like_plasticity_in_focal_hand_dystonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(12)00420-7 DB - PRIME DP - Unbound Medicine ER -