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Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde.
Eur J Med Chem. 2012 Dec; 58:323-31.EJ

Abstract

Eleven mononuclear copper(II), nickel(II), zinc(II) and cobalt(II) complexes of Schiff base ligands derived from 3,5-dibromosalicylaldehyde/3,5-dichlorosalicylaldehyde were synthesized and determined by single crystal X-ray analysis. The crystal structures of complexes 1, 2, 4, 5, 6, 8 and 11 present the square-planar coordination geometry at the metal center and complexes 7, 9 and 10 show the distorted tetrahedral geometry. While one copper center in 3 has a square-planar geometry, the other copper is slightly distorted square-planar. The inhibitory activities of all the obtained complexes were tested in vitro against jack bean urease. It was found that Schiff base copper(II) complexes 1, 3, 5, 8 and 11 showed strong urease inhibitory activities (IC(50) = 1.51-3.52 μM) compared with acetohydroxamic acid (IC(50) = 62.52 μM), which was a positive reference. Their structure-activity relationships were further discussed.

Authors+Show Affiliations

Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23142672

Citation

Cui, Yongming, et al. "Synthesis, Structures and Urease Inhibition Studies of Schiff Base Metal Complexes Derived From 3,5-dibromosalicylaldehyde." European Journal of Medicinal Chemistry, vol. 58, 2012, pp. 323-31.
Cui Y, Dong X, Li Y, et al. Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde. Eur J Med Chem. 2012;58:323-31.
Cui, Y., Dong, X., Li, Y., Li, Z., & Chen, W. (2012). Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde. European Journal of Medicinal Chemistry, 58, 323-31. https://doi.org/10.1016/j.ejmech.2012.09.037
Cui Y, et al. Synthesis, Structures and Urease Inhibition Studies of Schiff Base Metal Complexes Derived From 3,5-dibromosalicylaldehyde. Eur J Med Chem. 2012;58:323-31. PubMed PMID: 23142672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde. AU - Cui,Yongming, AU - Dong,Xiongwei, AU - Li,Yuguang, AU - Li,Zuowen, AU - Chen,Wu, Y1 - 2012/10/03/ PY - 2012/05/13/received PY - 2012/08/22/revised PY - 2012/09/10/accepted PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2013/5/17/medline SP - 323 EP - 31 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 58 N2 - Eleven mononuclear copper(II), nickel(II), zinc(II) and cobalt(II) complexes of Schiff base ligands derived from 3,5-dibromosalicylaldehyde/3,5-dichlorosalicylaldehyde were synthesized and determined by single crystal X-ray analysis. The crystal structures of complexes 1, 2, 4, 5, 6, 8 and 11 present the square-planar coordination geometry at the metal center and complexes 7, 9 and 10 show the distorted tetrahedral geometry. While one copper center in 3 has a square-planar geometry, the other copper is slightly distorted square-planar. The inhibitory activities of all the obtained complexes were tested in vitro against jack bean urease. It was found that Schiff base copper(II) complexes 1, 3, 5, 8 and 11 showed strong urease inhibitory activities (IC(50) = 1.51-3.52 μM) compared with acetohydroxamic acid (IC(50) = 62.52 μM), which was a positive reference. Their structure-activity relationships were further discussed. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/23142672/Synthesis_structures_and_urease_inhibition_studies_of_Schiff_base_metal_complexes_derived_from_35_dibromosalicylaldehyde_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(12)00576-4 DB - PRIME DP - Unbound Medicine ER -