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Memantine attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in rats.
Neurosci Lett 2012; 531(2):198-203NL

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) is an illegal drug that can induce life-threatening hyperthermia. No effective pharmacological treatment for MDMA-induced hyperthermia has yet been established. We investigated the effects of memantine, a non-competitive N-methyl-D-aspartate (NMDA)-type glutamate receptor antagonist and an α-7 nicotinic acetylcholine receptor (nAChR) antagonist, on MDMA-induced hyperthermia in rats. Treatment of animals with memantine (10 or 20 mg/kg) either before or after MDMA (10 mg/kg) administration significantly decreased the peak body temperature. Results from our microdialysis study indicated that pretreatment with memantine (20 mg/kg) before MDMA administration had no effect on the MDMA-induced increase in serotonin (5-HT) and dopamine (DA) levels in the anterior hypothalamus. MDMA-induced hyperthermia was significantly suppressed by pretreatment with the non-competitive NMDA receptor antagonist MK-801 (0.5 mg/kg) and the competitive NMDA antagonist CGS 19755 (5 mg/kg), but not by the selective α-7 nAChR antagonist methyllycaconitine (6 or 10 mg/kg). These results indicate that the inhibitory effect of memantine on MDMA-induced hyperthermia may be due to its activity as an NMDA receptor antagonist and not as a result of a direct effect on the 5-HT or DA systems. The present study suggests that moderate doses of memantine may be useful for the treatment of MDMA-induced hyperthermia in humans.

Authors+Show Affiliations

Department of Psychiatry, Jichi Medical University, Tochigi, Japan. midorin@jichi.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23142720

Citation

Nisijima, Koichi, et al. "Memantine Attenuates 3,4-methylenedioxymethamphetamine-induced Hyperthermia in Rats." Neuroscience Letters, vol. 531, no. 2, 2012, pp. 198-203.
Nisijima K, Kuboshima K, Shioda K, et al. Memantine attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in rats. Neurosci Lett. 2012;531(2):198-203.
Nisijima, K., Kuboshima, K., Shioda, K., Yoshino, T., Iwamura, T., & Kato, S. (2012). Memantine attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in rats. Neuroscience Letters, 531(2), pp. 198-203. doi:10.1016/j.neulet.2012.10.059.
Nisijima K, et al. Memantine Attenuates 3,4-methylenedioxymethamphetamine-induced Hyperthermia in Rats. Neurosci Lett. 2012 Dec 7;531(2):198-203. PubMed PMID: 23142720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memantine attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in rats. AU - Nisijima,Koichi, AU - Kuboshima,Kyoko, AU - Shioda,Katsutoshi, AU - Yoshino,Tatuki, AU - Iwamura,Tatsunori, AU - Kato,Satoshi, Y1 - 2012/11/06/ PY - 2012/09/07/received PY - 2012/10/23/revised PY - 2012/10/25/accepted PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2013/7/23/medline SP - 198 EP - 203 JF - Neuroscience letters JO - Neurosci. Lett. VL - 531 IS - 2 N2 - 3,4-Methylenedioxymethamphetamine (MDMA) is an illegal drug that can induce life-threatening hyperthermia. No effective pharmacological treatment for MDMA-induced hyperthermia has yet been established. We investigated the effects of memantine, a non-competitive N-methyl-D-aspartate (NMDA)-type glutamate receptor antagonist and an α-7 nicotinic acetylcholine receptor (nAChR) antagonist, on MDMA-induced hyperthermia in rats. Treatment of animals with memantine (10 or 20 mg/kg) either before or after MDMA (10 mg/kg) administration significantly decreased the peak body temperature. Results from our microdialysis study indicated that pretreatment with memantine (20 mg/kg) before MDMA administration had no effect on the MDMA-induced increase in serotonin (5-HT) and dopamine (DA) levels in the anterior hypothalamus. MDMA-induced hyperthermia was significantly suppressed by pretreatment with the non-competitive NMDA receptor antagonist MK-801 (0.5 mg/kg) and the competitive NMDA antagonist CGS 19755 (5 mg/kg), but not by the selective α-7 nAChR antagonist methyllycaconitine (6 or 10 mg/kg). These results indicate that the inhibitory effect of memantine on MDMA-induced hyperthermia may be due to its activity as an NMDA receptor antagonist and not as a result of a direct effect on the 5-HT or DA systems. The present study suggests that moderate doses of memantine may be useful for the treatment of MDMA-induced hyperthermia in humans. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/23142720/Memantine_attenuates_34_methylenedioxymethamphetamine_induced_hyperthermia_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(12)01441-3 DB - PRIME DP - Unbound Medicine ER -