Tags

Type your tag names separated by a space and hit enter

Respiratory muscle function in patients with cystic fibrosis.
Pediatr Pulmonol 2013; 48(9):865-73PP

Abstract

Respiratory muscle function in patients with cystic fibrosis (CF) can be assessed by measurement of maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and pressure-time index of the respiratory muscles (PTImus). We investigated the differences in maximal respiratory pressures and PTImus between CF patients with no gross hyperinflation and healthy controls and described the effects of pulmonary function and nutrition impairment on respiratory muscle function in this group of CF patients. Forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC) and maximal expiratory flow between 25% and 75% of VC (MEF25-75), body mass index (BMI), upper arm muscle area (UAMA), Pimax , Pemax , and PTImus were assessed in 140 CF patients and in a control group of 140 healthy subjects matched for age and gender. Median Pimax and Pemax were significantly lower in CF patients compared to the controls [Pimax = 74 (57-94) in CF vs. 84 (66-102) in controls, P = 0.009], [Pemax = 71 (50-95) in CF vs. 84 (66-102) in controls, P < 0.001]. Median PTImus in CF patients compared to controls was significantly increased [PTImus = 0.110 (0.076-0.160) in CF vs. 0.094 (0.070-0.137) in controls, P = 0.049] and it was significantly higher in CF patients with impaired pulmonary function. In CF patients, PTImus was significantly negatively related to upper arm muscle area (r = 0.184, P = 0.031). These findings suggest that CF patients with no severe lung disease compared to healthy subjects exhibit impaired respiratory muscle function, while CF patients with impaired pulmonary function and nutrition indices exhibit higher PTImus values.

Authors+Show Affiliations

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0SW, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23143864

Citation

Dassios, Theodore, et al. "Respiratory Muscle Function in Patients With Cystic Fibrosis." Pediatric Pulmonology, vol. 48, no. 9, 2013, pp. 865-73.
Dassios T, Katelari A, Doudounakis S, et al. Respiratory muscle function in patients with cystic fibrosis. Pediatr Pulmonol. 2013;48(9):865-73.
Dassios, T., Katelari, A., Doudounakis, S., Mantagos, S., & Dimitriou, G. (2013). Respiratory muscle function in patients with cystic fibrosis. Pediatric Pulmonology, 48(9), pp. 865-73. doi:10.1002/ppul.22709.
Dassios T, et al. Respiratory Muscle Function in Patients With Cystic Fibrosis. Pediatr Pulmonol. 2013;48(9):865-73. PubMed PMID: 23143864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory muscle function in patients with cystic fibrosis. AU - Dassios,Theodore, AU - Katelari,Anna, AU - Doudounakis,Stavros, AU - Mantagos,Stefanos, AU - Dimitriou,Gabriel, Y1 - 2012/11/09/ PY - 2012/04/29/received PY - 2012/08/19/accepted PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2014/4/4/medline KW - cystic fibrosis KW - pressure-time index of the respiratory muscles KW - respiratory muscles strength SP - 865 EP - 73 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 48 IS - 9 N2 - Respiratory muscle function in patients with cystic fibrosis (CF) can be assessed by measurement of maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and pressure-time index of the respiratory muscles (PTImus). We investigated the differences in maximal respiratory pressures and PTImus between CF patients with no gross hyperinflation and healthy controls and described the effects of pulmonary function and nutrition impairment on respiratory muscle function in this group of CF patients. Forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC) and maximal expiratory flow between 25% and 75% of VC (MEF25-75), body mass index (BMI), upper arm muscle area (UAMA), Pimax , Pemax , and PTImus were assessed in 140 CF patients and in a control group of 140 healthy subjects matched for age and gender. Median Pimax and Pemax were significantly lower in CF patients compared to the controls [Pimax = 74 (57-94) in CF vs. 84 (66-102) in controls, P = 0.009], [Pemax = 71 (50-95) in CF vs. 84 (66-102) in controls, P < 0.001]. Median PTImus in CF patients compared to controls was significantly increased [PTImus = 0.110 (0.076-0.160) in CF vs. 0.094 (0.070-0.137) in controls, P = 0.049] and it was significantly higher in CF patients with impaired pulmonary function. In CF patients, PTImus was significantly negatively related to upper arm muscle area (r = 0.184, P = 0.031). These findings suggest that CF patients with no severe lung disease compared to healthy subjects exhibit impaired respiratory muscle function, while CF patients with impaired pulmonary function and nutrition indices exhibit higher PTImus values. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/23143864/Respiratory_muscle_function_in_patients_with_cystic_fibrosis_ L2 - https://doi.org/10.1002/ppul.22709 DB - PRIME DP - Unbound Medicine ER -