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Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis.
Br J Ophthalmol 2013; 97(4):389-94BJ

Abstract

BACKGROUND

Epidemiologists have recently investigated sunlight exposure as a risk factor for age-related macular degeneration (AMD), but there remains an ongoing dispute over this association due to insufficient evidence and unreliable data.

OBJECTIVES

To analyse comprehensively the epidemiological literature concerning the association between AMD and sunlight exposure.

METHODS

We systematically reviewed the epidemiological literature concerning the association between AMD and sunlight exposure. An electronic search was performed of PubMed, Web of Science and CNKI, which was supplemented by hand searching. The selection of studies, data abstraction and quality assessment were performed independently by three reviewers. After these steps, we performed a random-effects meta-analysis, followed by subgroup analysis and sensitivity analysis, including a random-effects meta-regression for study-specific covariates.

RESULTS

Fourteen studies were identified. Twelve studies identified an increasing risk of AMD with greater sunlight exposure, six of which reported significant risks. The pooled OR was 1.379 (95% CI 1.091 to 1.745). The subgroup of non-population-based studies revealed a significant risk (OR 2.018, 1.248 to 3.265, p=0.004). We identified the gross domestic product (GDP) per capita (p=0.048), but not the latitude (p=0.21), as a factor that led to heterogeneity according to the meta-regression.

CONCLUSIONS

The epidemiological literature published to date indicates that individuals with more sunlight exposure are at a significantly increased risk of AMD. The OR significantly decreased with increasing GDP per capita.

Authors+Show Affiliations

School of Public Health, China Medical University, Shenyang, Liaoning, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

23143904

Citation

Sui, Guo-Yuan, et al. "Is Sunlight Exposure a Risk Factor for Age-related Macular Degeneration? a Systematic Review and Meta-analysis." The British Journal of Ophthalmology, vol. 97, no. 4, 2013, pp. 389-94.
Sui GY, Liu GC, Liu GY, et al. Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br J Ophthalmol. 2013;97(4):389-94.
Sui, G. Y., Liu, G. C., Liu, G. Y., Gao, Y. Y., Deng, Y., Wang, W. Y., ... Wang, L. (2013). Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. The British Journal of Ophthalmology, 97(4), pp. 389-94. doi:10.1136/bjophthalmol-2012-302281.
Sui GY, et al. Is Sunlight Exposure a Risk Factor for Age-related Macular Degeneration? a Systematic Review and Meta-analysis. Br J Ophthalmol. 2013;97(4):389-94. PubMed PMID: 23143904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. AU - Sui,Guo-Yuan, AU - Liu,Guang-Cong, AU - Liu,Guang-Ying, AU - Gao,Yan-Yan, AU - Deng,Yan, AU - Wang,Wen-Ying, AU - Tong,Shu-Hui, AU - Wang,Lie, Y1 - 2012/11/10/ PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2013/5/17/medline SP - 389 EP - 94 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 97 IS - 4 N2 - BACKGROUND: Epidemiologists have recently investigated sunlight exposure as a risk factor for age-related macular degeneration (AMD), but there remains an ongoing dispute over this association due to insufficient evidence and unreliable data. OBJECTIVES: To analyse comprehensively the epidemiological literature concerning the association between AMD and sunlight exposure. METHODS: We systematically reviewed the epidemiological literature concerning the association between AMD and sunlight exposure. An electronic search was performed of PubMed, Web of Science and CNKI, which was supplemented by hand searching. The selection of studies, data abstraction and quality assessment were performed independently by three reviewers. After these steps, we performed a random-effects meta-analysis, followed by subgroup analysis and sensitivity analysis, including a random-effects meta-regression for study-specific covariates. RESULTS: Fourteen studies were identified. Twelve studies identified an increasing risk of AMD with greater sunlight exposure, six of which reported significant risks. The pooled OR was 1.379 (95% CI 1.091 to 1.745). The subgroup of non-population-based studies revealed a significant risk (OR 2.018, 1.248 to 3.265, p=0.004). We identified the gross domestic product (GDP) per capita (p=0.048), but not the latitude (p=0.21), as a factor that led to heterogeneity according to the meta-regression. CONCLUSIONS: The epidemiological literature published to date indicates that individuals with more sunlight exposure are at a significantly increased risk of AMD. The OR significantly decreased with increasing GDP per capita. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/23143904/full_citation L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=23143904 DB - PRIME DP - Unbound Medicine ER -