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Head injury and Parkinson's disease: a population-based study.
Mov Disord. 2012 Nov; 27(13):1632-5.MD

Abstract

BACKGROUND

The epidemiological evidence on head injury and the risk of Parkinson's disease (PD) has been inconsistent.

METHODS

We examined the relation between previous hospitalization for head injury and PD using a population-based nested case-control design based on the Swedish National Patient Register from 2001 until 2007, including 18,648 PD cases and 93,240 controls, randomly selected from the general population. Exposure was defined as hospitalization for head injury between 1987 and index date.

RESULTS

Overall, previous hospitalization resulting from head injury was associated with an increased risk of PD; this association appeared to be largely explained by head injuries experienced recently, especially within 1 year before PD ascertainment.

CONCLUSIONS

Our results do not provide convincing evidence for a causal relationship between head injury later in life and PD.

Authors+Show Affiliations

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23143933

Citation

Fang, Fang, et al. "Head Injury and Parkinson's Disease: a Population-based Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 27, no. 13, 2012, pp. 1632-5.
Fang F, Chen H, Feldman AL, et al. Head injury and Parkinson's disease: a population-based study. Mov Disord. 2012;27(13):1632-5.
Fang, F., Chen, H., Feldman, A. L., Kamel, F., Ye, W., & Wirdefeldt, K. (2012). Head injury and Parkinson's disease: a population-based study. Movement Disorders : Official Journal of the Movement Disorder Society, 27(13), 1632-5. https://doi.org/10.1002/mds.25143
Fang F, et al. Head Injury and Parkinson's Disease: a Population-based Study. Mov Disord. 2012;27(13):1632-5. PubMed PMID: 23143933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head injury and Parkinson's disease: a population-based study. AU - Fang,Fang, AU - Chen,Honglei, AU - Feldman,Adina L, AU - Kamel,Freya, AU - Ye,Weimin, AU - Wirdefeldt,Karin, Y1 - 2012/11/09/ PY - 2012/03/14/received PY - 2012/06/12/revised PY - 2012/07/17/accepted PY - 2012/11/13/entrez PY - 2012/11/13/pubmed PY - 2013/5/15/medline SP - 1632 EP - 5 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 27 IS - 13 N2 - BACKGROUND: The epidemiological evidence on head injury and the risk of Parkinson's disease (PD) has been inconsistent. METHODS: We examined the relation between previous hospitalization for head injury and PD using a population-based nested case-control design based on the Swedish National Patient Register from 2001 until 2007, including 18,648 PD cases and 93,240 controls, randomly selected from the general population. Exposure was defined as hospitalization for head injury between 1987 and index date. RESULTS: Overall, previous hospitalization resulting from head injury was associated with an increased risk of PD; this association appeared to be largely explained by head injuries experienced recently, especially within 1 year before PD ascertainment. CONCLUSIONS: Our results do not provide convincing evidence for a causal relationship between head injury later in life and PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/23143933/Head_injury_and_Parkinson's_disease:_a_population_based_study_ L2 - https://doi.org/10.1002/mds.25143 DB - PRIME DP - Unbound Medicine ER -