Tags

Type your tag names separated by a space and hit enter

Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis.
Obes Rev 2013; 14(3):222-31OR

Abstract

The aims of our meta-analysis were (i) to quantify the predictability of childhood overweight and obesity on the risk of incident asthma; and (ii) to evaluate the gender difference on this relationship. The selection criteria included prospective cohort paediatric studies which use age- and sex-specific body mass index (BMI) as a measure of childhood overweight and the primary outcome of incident asthma. A total of 1,027 studies were initially identified through online database searches, and finally 6 studies met the inclusion criteria. The combined result of reported relative risk from the 6 included studies revealed that overweight children conferred increased risks of incident asthma as compared with non-overweight children (relative risk, 1.19; 95% confidence interval [CI], 1.03-1.37). The relationship was further elevated for obesity vs. non-obesity (relative risk, 2.02; 95% CI, 1.16-3.50). A dose-responsiveness of elevated BMI on asthma incidence was observed (P for trend, 0.004). Obese boys had a significantly larger effect than obese girls (relative risk, boys: 2.47; 95% CI, 1.57-3.87; girls: 1.25; 95% CI, 0.51-3.03), with significant dose-dependent effect. Proposed mechanisms of gender difference could be through pulmonary mechanics, sleep disordered breathing and leptin. Further research might be needed to better understand the exact mechanism of gender difference on the obesity-asthma relationship.

Authors+Show Affiliations

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

23145849

Citation

Chen, Y C., et al. "Gender Difference of Childhood Overweight and Obesity in Predicting the Risk of Incident Asthma: a Systematic Review and Meta-analysis." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 14, no. 3, 2013, pp. 222-31.
Chen YC, Dong GH, Lin KC, et al. Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obes Rev. 2013;14(3):222-31.
Chen, Y. C., Dong, G. H., Lin, K. C., & Lee, Y. L. (2013). Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 14(3), pp. 222-31. doi:10.1111/j.1467-789X.2012.01055.x.
Chen YC, et al. Gender Difference of Childhood Overweight and Obesity in Predicting the Risk of Incident Asthma: a Systematic Review and Meta-analysis. Obes Rev. 2013;14(3):222-31. PubMed PMID: 23145849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. AU - Chen,Y C, AU - Dong,G H, AU - Lin,K C, AU - Lee,Y L, Y1 - 2012/11/12/ PY - 2011/10/18/received PY - 2012/08/29/revised PY - 2012/09/23/accepted PY - 2012/11/14/entrez PY - 2012/11/14/pubmed PY - 2013/5/7/medline SP - 222 EP - 31 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 14 IS - 3 N2 - The aims of our meta-analysis were (i) to quantify the predictability of childhood overweight and obesity on the risk of incident asthma; and (ii) to evaluate the gender difference on this relationship. The selection criteria included prospective cohort paediatric studies which use age- and sex-specific body mass index (BMI) as a measure of childhood overweight and the primary outcome of incident asthma. A total of 1,027 studies were initially identified through online database searches, and finally 6 studies met the inclusion criteria. The combined result of reported relative risk from the 6 included studies revealed that overweight children conferred increased risks of incident asthma as compared with non-overweight children (relative risk, 1.19; 95% confidence interval [CI], 1.03-1.37). The relationship was further elevated for obesity vs. non-obesity (relative risk, 2.02; 95% CI, 1.16-3.50). A dose-responsiveness of elevated BMI on asthma incidence was observed (P for trend, 0.004). Obese boys had a significantly larger effect than obese girls (relative risk, boys: 2.47; 95% CI, 1.57-3.87; girls: 1.25; 95% CI, 0.51-3.03), with significant dose-dependent effect. Proposed mechanisms of gender difference could be through pulmonary mechanics, sleep disordered breathing and leptin. Further research might be needed to better understand the exact mechanism of gender difference on the obesity-asthma relationship. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/23145849/Gender_difference_of_childhood_overweight_and_obesity_in_predicting_the_risk_of_incident_asthma:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/j.1467-789X.2012.01055.x DB - PRIME DP - Unbound Medicine ER -