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Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin.
J Ethnopharmacol. 2013 Jan 09; 145(1):233-40.JE

Abstract

ETHNOPHARMACOLOGY RELEVANCE

Ginseng (Panax ginseng C. A. Meyer) has been recorded to treat 'Xiao-ke' (emaciation and thirst) symptom in many ancient Chinese medical literatures (such as 'Shen Nong Ben Cao Jing') for thousands of years. 'Xiao-ke' symptom, in general, indicates diabetes mellitus.

AIM OF THE STUDY

Malonyl ginsenosides (MGR) are natural ginsenosides which exist in both fresh and air-dried ginseng. The objective of this study is to determine the antidiabetic function of MGR on type 2 diabetes.

MATERIALS AND METHODS

High fat diet-fed and streptozotocin-induced diabetic rats were treated with 50 and 100mg/kg/d of MGR or vehicle for 3 weeks. The effects of MGR on fasting blood glucose (FBG), intraperitoneal glucose tolerance test (IPGTT), serum insulin (SI), insulin tolerance test (ITT), body weight, total cholesterol (TC), and triglyceride (TG) levels in type 2 diabetic rats were measured.

RESULTS

After 3 weeks of treatment, MGR administration showed significantly lower FBG levels compared to the diabetic control group. In glucose tolerance test, IPGTT data showed that both MGR 50 and 100mg/kg groups significantly increased the glucose disposal after glucose load. The ITT also showed improvement of insulin sensitivity during 120 min of insulin treatment. In addition, MGR reduced TG and TC contents while showed no effect on body weight in diabetic rats.

CONCLUSION

The findings from this study suggest that MGR can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes.

Authors+Show Affiliations

Institute of Agricultural Modernization, Jilin Agricultural University, Changchun 130118, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23147499

Citation

Liu, Zhi, et al. "Antidiabetic Effects of Malonyl Ginsenosides From Panax Ginseng On Type 2 Diabetic Rats Induced By High-fat Diet and Streptozotocin." Journal of Ethnopharmacology, vol. 145, no. 1, 2013, pp. 233-40.
Liu Z, Li W, Li X, et al. Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J Ethnopharmacol. 2013;145(1):233-40.
Liu, Z., Li, W., Li, X., Zhang, M., Chen, L., Zheng, Y. N., Sun, G. Z., & Ruan, C. C. (2013). Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. Journal of Ethnopharmacology, 145(1), 233-40. https://doi.org/10.1016/j.jep.2012.10.058
Liu Z, et al. Antidiabetic Effects of Malonyl Ginsenosides From Panax Ginseng On Type 2 Diabetic Rats Induced By High-fat Diet and Streptozotocin. J Ethnopharmacol. 2013 Jan 9;145(1):233-40. PubMed PMID: 23147499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. AU - Liu,Zhi, AU - Li,Wei, AU - Li,Xiang, AU - Zhang,Ming, AU - Chen,Li, AU - Zheng,Yi-nan, AU - Sun,Guang-zhi, AU - Ruan,Chang-chun, Y1 - 2012/11/10/ PY - 2012/04/09/received PY - 2012/09/18/revised PY - 2012/10/27/accepted PY - 2012/11/14/entrez PY - 2012/11/14/pubmed PY - 2013/6/15/medline SP - 233 EP - 40 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 145 IS - 1 N2 - ETHNOPHARMACOLOGY RELEVANCE: Ginseng (Panax ginseng C. A. Meyer) has been recorded to treat 'Xiao-ke' (emaciation and thirst) symptom in many ancient Chinese medical literatures (such as 'Shen Nong Ben Cao Jing') for thousands of years. 'Xiao-ke' symptom, in general, indicates diabetes mellitus. AIM OF THE STUDY: Malonyl ginsenosides (MGR) are natural ginsenosides which exist in both fresh and air-dried ginseng. The objective of this study is to determine the antidiabetic function of MGR on type 2 diabetes. MATERIALS AND METHODS: High fat diet-fed and streptozotocin-induced diabetic rats were treated with 50 and 100mg/kg/d of MGR or vehicle for 3 weeks. The effects of MGR on fasting blood glucose (FBG), intraperitoneal glucose tolerance test (IPGTT), serum insulin (SI), insulin tolerance test (ITT), body weight, total cholesterol (TC), and triglyceride (TG) levels in type 2 diabetic rats were measured. RESULTS: After 3 weeks of treatment, MGR administration showed significantly lower FBG levels compared to the diabetic control group. In glucose tolerance test, IPGTT data showed that both MGR 50 and 100mg/kg groups significantly increased the glucose disposal after glucose load. The ITT also showed improvement of insulin sensitivity during 120 min of insulin treatment. In addition, MGR reduced TG and TC contents while showed no effect on body weight in diabetic rats. CONCLUSION: The findings from this study suggest that MGR can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/23147499/Antidiabetic_effects_of_malonyl_ginsenosides_from_Panax_ginseng_on_type_2_diabetic_rats_induced_by_high_fat_diet_and_streptozotocin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00756-8 DB - PRIME DP - Unbound Medicine ER -