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Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can).
Cancer Causes Control. 2013 Jan; 24(1):107-16.CC

Abstract

PURPOSE

Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma.

METHODS

The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with information on blood pressure, lipids, glucose, and BMI available in 578,700 individuals. Cox proportional hazards analysis was used to calculate hazard ratio (HR) of gastric adenocarcinoma using metabolic risk factors categorized into quintiles and transformed into z-scores (with mean = 0 and SD = 1). The standardized sum of all z-scores created a composite MetS score.

RESULTS

In total, 1,210 incident cases of gastric adenocarcinoma were identified. Glucose was significantly associated with the risk of gastric adenocarcinoma [calibrated HR 1.58 (1.14-2.20) per one unit increment in z-score] in women. There was a statistically significant association between triglycerides and risk of gastric adenocarcinoma per mmol increment in triglycerides [HR 1.20 (1.06-1.36) per mmol] but not for the adjusted z-score in women. There were no significant association between any metabolic factors and gastric cancer among men. The composite MetS score was associated with the risk of gastric adenocarcinoma in women [HR 1.18 (1.00-1.38) per one unit increment in z-score] but not in men.

CONCLUSIONS

Glucose and high levels of the composite MetS score were associated with an increased risk of gastric adenocarcinoma in women but not in men.

Authors+Show Affiliations

Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. bjorn.lindkvist@vgregion.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23149498

Citation

Lindkvist, Björn, et al. "Prospective Cohort Study of Metabolic Risk Factors and Gastric Adenocarcinoma Risk in the Metabolic Syndrome and Cancer Project (Me-Can)." Cancer Causes & Control : CCC, vol. 24, no. 1, 2013, pp. 107-16.
Lindkvist B, Almquist M, Bjørge T, et al. Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can). Cancer Causes Control. 2013;24(1):107-16.
Lindkvist, B., Almquist, M., Bjørge, T., Stocks, T., Borena, W., Johansen, D., Hallmans, G., Engeland, A., Nagel, G., Jonsson, H., Selmer, R., Diem, G., Häggström, C., Tretli, S., Stattin, P., & Manjer, J. (2013). Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can). Cancer Causes & Control : CCC, 24(1), 107-16. https://doi.org/10.1007/s10552-012-0096-6
Lindkvist B, et al. Prospective Cohort Study of Metabolic Risk Factors and Gastric Adenocarcinoma Risk in the Metabolic Syndrome and Cancer Project (Me-Can). Cancer Causes Control. 2013;24(1):107-16. PubMed PMID: 23149498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can). AU - Lindkvist,Björn, AU - Almquist,Martin, AU - Bjørge,Tone, AU - Stocks,Tanja, AU - Borena,Wegene, AU - Johansen,Dorthe, AU - Hallmans,Göran, AU - Engeland,Anders, AU - Nagel,Gabriele, AU - Jonsson,Håkan, AU - Selmer,Randi, AU - Diem,Guenter, AU - Häggström,Christel, AU - Tretli,Steinar, AU - Stattin,Pär, AU - Manjer,Jonas, Y1 - 2012/11/13/ PY - 2012/06/24/received PY - 2012/11/02/accepted PY - 2012/11/15/entrez PY - 2012/11/15/pubmed PY - 2013/5/29/medline SP - 107 EP - 16 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 1 N2 - PURPOSE: Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. METHODS: The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with information on blood pressure, lipids, glucose, and BMI available in 578,700 individuals. Cox proportional hazards analysis was used to calculate hazard ratio (HR) of gastric adenocarcinoma using metabolic risk factors categorized into quintiles and transformed into z-scores (with mean = 0 and SD = 1). The standardized sum of all z-scores created a composite MetS score. RESULTS: In total, 1,210 incident cases of gastric adenocarcinoma were identified. Glucose was significantly associated with the risk of gastric adenocarcinoma [calibrated HR 1.58 (1.14-2.20) per one unit increment in z-score] in women. There was a statistically significant association between triglycerides and risk of gastric adenocarcinoma per mmol increment in triglycerides [HR 1.20 (1.06-1.36) per mmol] but not for the adjusted z-score in women. There were no significant association between any metabolic factors and gastric cancer among men. The composite MetS score was associated with the risk of gastric adenocarcinoma in women [HR 1.18 (1.00-1.38) per one unit increment in z-score] but not in men. CONCLUSIONS: Glucose and high levels of the composite MetS score were associated with an increased risk of gastric adenocarcinoma in women but not in men. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23149498/Prospective_cohort_study_of_metabolic_risk_factors_and_gastric_adenocarcinoma_risk_in_the_Metabolic_Syndrome_and_Cancer_Project__Me_Can__ L2 - https://doi.org/10.1007/s10552-012-0096-6 DB - PRIME DP - Unbound Medicine ER -