Tags

Type your tag names separated by a space and hit enter

Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease.
Neurology. 2012 Dec 11; 79(24):2307-14.Neur

Abstract

OBJECTIVE

To determine whether evidence of neuronal dysfunction or demise preceded deposition of Lewy pathology in vulnerable neurons in Parkinson disease (PD).

METHODS

We examined the extent of nigral dysfunction and degeneration among 63 normal, incidental Lewy body disease (ILBD), and PD cases based on tyrosine hydroxylase (TH) immunoreactivity and neuron densities, respectively. The relationship between these markers and Lewy pathology (LP) burden in the substantia nigra (SN) and Braak PD stage was assessed.

RESULTS

Compared with normal subjects, ILBD cases displayed a significantly higher percentage of TH-negative cells and lower neuronal densities in the SN as early as Braak PD stages 1 and 2, before LP deposition in the nigrostriatal system. ILBD nigral neuron densities were intermediate between normal subjects and PD cases, and TH-negative percentages were higher in ILBD than either normal or PD cases. Furthermore, neuron density and neuronal dysfunction levels remained relatively constant across Braak PD stages in ILBD.

CONCLUSIONS

These results suggest that significant neurodegeneration and cellular dysfunction precede LP in the SN, challenging the pathogenic role of LP in PD and the assumption that ILBD always represents preclinical PD.

Authors+Show Affiliations

Parkinson's Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23152586

Citation

Milber, Joshua M., et al. "Lewy Pathology Is Not the First Sign of Degeneration in Vulnerable Neurons in Parkinson Disease." Neurology, vol. 79, no. 24, 2012, pp. 2307-14.
Milber JM, Noorigian JV, Morley JF, et al. Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. Neurology. 2012;79(24):2307-14.
Milber, J. M., Noorigian, J. V., Morley, J. F., Petrovitch, H., White, L., Ross, G. W., & Duda, J. E. (2012). Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. Neurology, 79(24), 2307-14. https://doi.org/10.1212/WNL.0b013e318278fe32
Milber JM, et al. Lewy Pathology Is Not the First Sign of Degeneration in Vulnerable Neurons in Parkinson Disease. Neurology. 2012 Dec 11;79(24):2307-14. PubMed PMID: 23152586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. AU - Milber,Joshua M, AU - Noorigian,Joseph V, AU - Morley,James F, AU - Petrovitch,Helen, AU - White,Lon, AU - Ross,G Webster, AU - Duda,John E, Y1 - 2012/11/14/ PY - 2012/11/16/entrez PY - 2012/11/16/pubmed PY - 2013/2/16/medline SP - 2307 EP - 14 JF - Neurology JO - Neurology VL - 79 IS - 24 N2 - OBJECTIVE: To determine whether evidence of neuronal dysfunction or demise preceded deposition of Lewy pathology in vulnerable neurons in Parkinson disease (PD). METHODS: We examined the extent of nigral dysfunction and degeneration among 63 normal, incidental Lewy body disease (ILBD), and PD cases based on tyrosine hydroxylase (TH) immunoreactivity and neuron densities, respectively. The relationship between these markers and Lewy pathology (LP) burden in the substantia nigra (SN) and Braak PD stage was assessed. RESULTS: Compared with normal subjects, ILBD cases displayed a significantly higher percentage of TH-negative cells and lower neuronal densities in the SN as early as Braak PD stages 1 and 2, before LP deposition in the nigrostriatal system. ILBD nigral neuron densities were intermediate between normal subjects and PD cases, and TH-negative percentages were higher in ILBD than either normal or PD cases. Furthermore, neuron density and neuronal dysfunction levels remained relatively constant across Braak PD stages in ILBD. CONCLUSIONS: These results suggest that significant neurodegeneration and cellular dysfunction precede LP in the SN, challenging the pathogenic role of LP in PD and the assumption that ILBD always represents preclinical PD. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/23152586/Lewy_pathology_is_not_the_first_sign_of_degeneration_in_vulnerable_neurons_in_Parkinson_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=23152586 DB - PRIME DP - Unbound Medicine ER -