Tags

Type your tag names separated by a space and hit enter

Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection.
Neuropharmacology. 2013 Apr; 67:78-87.N

Abstract

We investigated whether combinatorial post-injury treatment with progesterone (P4) and vitamin D hormone (VDH) would reduce ischemic injury more effectively than P4 alone in an oxygen glucose deprivation (OGD) model in primary cortical neurons and in a transient middle cerebral artery occlusion (tMCAO) model in rats. In the OGD model, P4 and VDH each showed neuroprotection individually, but combination of the "best" doses did not show substantial efficacy; instead, the lower dose of VDH in combination with P4 was the most effective. In the tMCAO model, P4 and VDH were given alone or in combination at different times post-occlusion for 7 days. In vivo data confirmed the in vitro findings and showed better infarct reduction at day 7 and functional outcomes (at 3, 5 and 7 days post-occlusion) after combinatorial treatment than when either agent was given alone. VDH, but not P4, upregulated heme oxygenase-1, suggesting a pathway for the neuroprotective effects of VDH differing from that of P4. The combination of P4 and VDH activated brain-derived neurotrophic factor and its specific receptor, tyrosine kinase receptor-B. Under specific conditions VDH potentiates P4's neuroprotective efficacy and should be considered as a potential partner of P4 in a low-cost, safe and effective combinatorial treatment for stroke.

Authors+Show Affiliations

Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Suite 5100, Emory University, Atlanta, GA 30322, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23154302

Citation

Atif, Fahim, et al. "Combination Treatment With Progesterone and Vitamin D Hormone Is More Effective Than Monotherapy in Ischemic Stroke: the Role of BDNF/TrkB/Erk1/2 Signaling in Neuroprotection." Neuropharmacology, vol. 67, 2013, pp. 78-87.
Atif F, Yousuf S, Sayeed I, et al. Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection. Neuropharmacology. 2013;67:78-87.
Atif, F., Yousuf, S., Sayeed, I., Ishrat, T., Hua, F., & Stein, D. G. (2013). Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection. Neuropharmacology, 67, 78-87. https://doi.org/10.1016/j.neuropharm.2012.10.004
Atif F, et al. Combination Treatment With Progesterone and Vitamin D Hormone Is More Effective Than Monotherapy in Ischemic Stroke: the Role of BDNF/TrkB/Erk1/2 Signaling in Neuroprotection. Neuropharmacology. 2013;67:78-87. PubMed PMID: 23154302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection. AU - Atif,Fahim, AU - Yousuf,Seema, AU - Sayeed,Iqbal, AU - Ishrat,Tauheed, AU - Hua,Fang, AU - Stein,Donald G, Y1 - 2012/11/12/ PY - 2012/05/02/received PY - 2012/09/04/revised PY - 2012/10/09/accepted PY - 2012/11/17/entrez PY - 2012/11/17/pubmed PY - 2013/11/5/medline SP - 78 EP - 87 JF - Neuropharmacology JO - Neuropharmacology VL - 67 N2 - We investigated whether combinatorial post-injury treatment with progesterone (P4) and vitamin D hormone (VDH) would reduce ischemic injury more effectively than P4 alone in an oxygen glucose deprivation (OGD) model in primary cortical neurons and in a transient middle cerebral artery occlusion (tMCAO) model in rats. In the OGD model, P4 and VDH each showed neuroprotection individually, but combination of the "best" doses did not show substantial efficacy; instead, the lower dose of VDH in combination with P4 was the most effective. In the tMCAO model, P4 and VDH were given alone or in combination at different times post-occlusion for 7 days. In vivo data confirmed the in vitro findings and showed better infarct reduction at day 7 and functional outcomes (at 3, 5 and 7 days post-occlusion) after combinatorial treatment than when either agent was given alone. VDH, but not P4, upregulated heme oxygenase-1, suggesting a pathway for the neuroprotective effects of VDH differing from that of P4. The combination of P4 and VDH activated brain-derived neurotrophic factor and its specific receptor, tyrosine kinase receptor-B. Under specific conditions VDH potentiates P4's neuroprotective efficacy and should be considered as a potential partner of P4 in a low-cost, safe and effective combinatorial treatment for stroke. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/23154302/Combination_treatment_with_progesterone_and_vitamin_D_hormone_is_more_effective_than_monotherapy_in_ischemic_stroke:_the_role_of_BDNF/TrkB/Erk1/2_signaling_in_neuroprotection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(12)00505-9 DB - PRIME DP - Unbound Medicine ER -