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Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis.
J Craniofac Surg. 2012 Nov; 23(7 Suppl 1):1959-63.JC

Abstract

Pierre Robin sequence and Treacher Collins syndrome are both associated with mandibular hypoplasia. It has been hypothesized, however, that the mandible may be differentially affected. The purpose of this study was to therefore compare mandibular morphology in children with Pierre Robin sequence with children with Treacher Collins syndrome using three-dimensional analysis of computed tomographic scans. A retrospective analysis was performed identifying children with Pierre Robin sequence and Treacher Collins syndrome undergoing computed tomography. Three-dimensional reconstruction was performed, and ramus height, mandibular body length, and gonial angle were measured. These were then compared with those in control children with normal mandibles and with the clinical norms corrected for age and sex based on previously published measurements. Mandibular body length was found to be significantly shorter for children with Pierre Robin sequence, whereas ramus height was significantly shorter for children with Treacher Collins syndrome. This resulted in distinctly different ramus height-mandibular body length ratios. In addition, the gonial angle was more obtuse in both the Pierre Robin sequence and Treacher Collins syndrome groups compared with the controls. Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome thus revealed distinctly different patterns of mandibular hypoplasia relative to normal controls. These findings underscore distinct considerations that must be made in surgical planning for reconstruction.

Authors+Show Affiliations

Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, CA 94305, USANo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23154353

Citation

Chung, Michael T., et al. "Pierre Robin Sequence and Treacher Collins Hypoplastic Mandible Comparison Using Three-dimensional Morphometric Analysis." The Journal of Craniofacial Surgery, vol. 23, no. 7 Suppl 1, 2012, pp. 1959-63.
Chung MT, Levi B, Hyun JS, et al. Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis. J Craniofac Surg. 2012;23(7 Suppl 1):1959-63.
Chung, M. T., Levi, B., Hyun, J. S., Lo, D. D., Montoro, D. T., Lisiecki, J., Bradley, J. P., Buchman, S. R., Longaker, M. T., & Wan, D. C. (2012). Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis. The Journal of Craniofacial Surgery, 23(7 Suppl 1), 1959-63. https://doi.org/10.1097/SCS.0b013e318258bcf1
Chung MT, et al. Pierre Robin Sequence and Treacher Collins Hypoplastic Mandible Comparison Using Three-dimensional Morphometric Analysis. J Craniofac Surg. 2012;23(7 Suppl 1):1959-63. PubMed PMID: 23154353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis. AU - Chung,Michael T, AU - Levi,Benjamin, AU - Hyun,Jeong S, AU - Lo,David D, AU - Montoro,Daniel T, AU - Lisiecki,Jeffrey, AU - Bradley,James P, AU - Buchman,Steven R, AU - Longaker,Michael T, AU - Wan,Derrick C, PY - 2012/11/17/entrez PY - 2013/1/10/pubmed PY - 2013/12/18/medline SP - 1959 EP - 63 JF - The Journal of craniofacial surgery JO - J Craniofac Surg VL - 23 IS - 7 Suppl 1 N2 - Pierre Robin sequence and Treacher Collins syndrome are both associated with mandibular hypoplasia. It has been hypothesized, however, that the mandible may be differentially affected. The purpose of this study was to therefore compare mandibular morphology in children with Pierre Robin sequence with children with Treacher Collins syndrome using three-dimensional analysis of computed tomographic scans. A retrospective analysis was performed identifying children with Pierre Robin sequence and Treacher Collins syndrome undergoing computed tomography. Three-dimensional reconstruction was performed, and ramus height, mandibular body length, and gonial angle were measured. These were then compared with those in control children with normal mandibles and with the clinical norms corrected for age and sex based on previously published measurements. Mandibular body length was found to be significantly shorter for children with Pierre Robin sequence, whereas ramus height was significantly shorter for children with Treacher Collins syndrome. This resulted in distinctly different ramus height-mandibular body length ratios. In addition, the gonial angle was more obtuse in both the Pierre Robin sequence and Treacher Collins syndrome groups compared with the controls. Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome thus revealed distinctly different patterns of mandibular hypoplasia relative to normal controls. These findings underscore distinct considerations that must be made in surgical planning for reconstruction. SN - 1536-3732 UR - https://www.unboundmedicine.com/medline/citation/23154353/Pierre_Robin_sequence_and_Treacher_Collins_hypoplastic_mandible_comparison_using_three_dimensional_morphometric_analysis_ L2 - https://doi.org/10.1097/SCS.0b013e318258bcf1 DB - PRIME DP - Unbound Medicine ER -