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Formation of alpha-deoxyadenosine in polydeoxynucleotides exposed to ionizing radiation under anoxic conditions.
Radiat Res. 1990 Mar; 121(3):328-37.RR

Abstract

When poly(dA), poly(dA-dT), and salmon testis DNA were gamma-irradiated under nitrogen, the major deoxyadenosine damage product (excluding liberated adenine) was identified as the alpha-anomer of deoxyadenosine. The yields of alpha-deoxyadenosine from poly(dA), poly(dA-dT), and salmon testis DNA irradiated with a dose of 500 Gy under anoxic conditions were 1.5, 1.3, and 1.3%, respectively. No alpha-deoxyadenosine was detected after irradiation under oxic conditions. The presence of nucleotides with the alpha-configuration at the anomeric carbon atom in the DNA chain may have a significant effect on its tertiary structure and possibly modify its biological activity.

Authors+Show Affiliations

Department of Radiology, Wake Forest University Medical Center, Winston-Salem, North Carolina 27103.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2315449

Citation

Lesiak, K B., and K T. Wheeler. "Formation of Alpha-deoxyadenosine in Polydeoxynucleotides Exposed to Ionizing Radiation Under Anoxic Conditions." Radiation Research, vol. 121, no. 3, 1990, pp. 328-37.
Lesiak KB, Wheeler KT. Formation of alpha-deoxyadenosine in polydeoxynucleotides exposed to ionizing radiation under anoxic conditions. Radiat Res. 1990;121(3):328-37.
Lesiak, K. B., & Wheeler, K. T. (1990). Formation of alpha-deoxyadenosine in polydeoxynucleotides exposed to ionizing radiation under anoxic conditions. Radiation Research, 121(3), 328-37.
Lesiak KB, Wheeler KT. Formation of Alpha-deoxyadenosine in Polydeoxynucleotides Exposed to Ionizing Radiation Under Anoxic Conditions. Radiat Res. 1990;121(3):328-37. PubMed PMID: 2315449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formation of alpha-deoxyadenosine in polydeoxynucleotides exposed to ionizing radiation under anoxic conditions. AU - Lesiak,K B, AU - Wheeler,K T, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 328 EP - 37 JF - Radiation research JO - Radiat. Res. VL - 121 IS - 3 N2 - When poly(dA), poly(dA-dT), and salmon testis DNA were gamma-irradiated under nitrogen, the major deoxyadenosine damage product (excluding liberated adenine) was identified as the alpha-anomer of deoxyadenosine. The yields of alpha-deoxyadenosine from poly(dA), poly(dA-dT), and salmon testis DNA irradiated with a dose of 500 Gy under anoxic conditions were 1.5, 1.3, and 1.3%, respectively. No alpha-deoxyadenosine was detected after irradiation under oxic conditions. The presence of nucleotides with the alpha-configuration at the anomeric carbon atom in the DNA chain may have a significant effect on its tertiary structure and possibly modify its biological activity. SN - 0033-7587 UR - https://www.unboundmedicine.com/medline/citation/2315449/Formation_of_alpha_deoxyadenosine_in_polydeoxynucleotides_exposed_to_ionizing_radiation_under_anoxic_conditions_ DB - PRIME DP - Unbound Medicine ER -