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Effects of deep brain stimulation in the caudal zona incerta on verbal fluency.
Stereotact Funct Neurosurg. 2013; 91(1):24-9.SF

Abstract

BACKGROUND

Deep brain stimulation (DBS) of the caudal zona incerta (cZi) is a relatively unexplored and promising treatment in patients with severe essential tremor (ET). Preliminary data further indicate that the ability to produce language may be slightly affected by the treatment.

OBJECTIVE

To evaluate the effects on verbal fluency following cZi DBS in patients with ET.

METHOD

Seventeen consecutive patients who had undergone DBS of the cZi for ET were tested regarding verbal fluency before surgery, 3 days after surgery and after 1 year. Ten patients were also evaluated by comparing performance on versus off stimulation after 1 year.

RESULTS

The total verbal fluency score decreased slightly, but significantly, from 22.7 (SD = 10.9) before surgery to 18.1 (SD = 7.5) 3 days after surgery (p = 0.036). After 1 year the score was nonsignificantly decreased to 20.1 (SD = 9.7, p = 0.2678). There was no detectable difference between stimulation on and off after 1 year.

CONCLUSION

There was a tendency of an immediate and mostly transient postoperative decline in verbal fluency following cZi DBS for ET. In some of the patients this reduction was, however, more pronounced and also sustained over time.

Authors+Show Affiliations

Department of Clinical Neuroscience, Neurosurgery, Karolinska University Hospital, Stockholm, Sweden. anders.fytagoridis@neuro.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23154815

Citation

Fytagoridis, Anders, et al. "Effects of Deep Brain Stimulation in the Caudal Zona Incerta On Verbal Fluency." Stereotactic and Functional Neurosurgery, vol. 91, no. 1, 2013, pp. 24-9.
Fytagoridis A, Sjöberg RL, Åström M, et al. Effects of deep brain stimulation in the caudal zona incerta on verbal fluency. Stereotact Funct Neurosurg. 2013;91(1):24-9.
Fytagoridis, A., Sjöberg, R. L., Åström, M., Fredricks, A., Nyberg, L., & Blomstedt, P. (2013). Effects of deep brain stimulation in the caudal zona incerta on verbal fluency. Stereotactic and Functional Neurosurgery, 91(1), 24-9. https://doi.org/10.1159/000342497
Fytagoridis A, et al. Effects of Deep Brain Stimulation in the Caudal Zona Incerta On Verbal Fluency. Stereotact Funct Neurosurg. 2013;91(1):24-9. PubMed PMID: 23154815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of deep brain stimulation in the caudal zona incerta on verbal fluency. AU - Fytagoridis,Anders, AU - Sjöberg,Rickard L, AU - Åström,Mattias, AU - Fredricks,Anna, AU - Nyberg,Lars, AU - Blomstedt,Patric, Y1 - 2012/11/13/ PY - 2012/01/24/received PY - 2012/08/11/accepted PY - 2012/11/17/entrez PY - 2012/11/17/pubmed PY - 2013/7/24/medline SP - 24 EP - 9 JF - Stereotactic and functional neurosurgery JO - Stereotact Funct Neurosurg VL - 91 IS - 1 N2 - BACKGROUND: Deep brain stimulation (DBS) of the caudal zona incerta (cZi) is a relatively unexplored and promising treatment in patients with severe essential tremor (ET). Preliminary data further indicate that the ability to produce language may be slightly affected by the treatment. OBJECTIVE: To evaluate the effects on verbal fluency following cZi DBS in patients with ET. METHOD: Seventeen consecutive patients who had undergone DBS of the cZi for ET were tested regarding verbal fluency before surgery, 3 days after surgery and after 1 year. Ten patients were also evaluated by comparing performance on versus off stimulation after 1 year. RESULTS: The total verbal fluency score decreased slightly, but significantly, from 22.7 (SD = 10.9) before surgery to 18.1 (SD = 7.5) 3 days after surgery (p = 0.036). After 1 year the score was nonsignificantly decreased to 20.1 (SD = 9.7, p = 0.2678). There was no detectable difference between stimulation on and off after 1 year. CONCLUSION: There was a tendency of an immediate and mostly transient postoperative decline in verbal fluency following cZi DBS for ET. In some of the patients this reduction was, however, more pronounced and also sustained over time. SN - 1423-0372 UR - https://www.unboundmedicine.com/medline/citation/23154815/Effects_of_deep_brain_stimulation_in_the_caudal_zona_incerta_on_verbal_fluency_ L2 - https://www.karger.com?DOI=10.1159/000342497 DB - PRIME DP - Unbound Medicine ER -