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Correlation of cataract with serum lipids, glucose and antioxidant activities: a case-control study.

Abstract

OBJECTIVE

The aim of this study is to evaluate the relationship between cataract development and serum lipids, glucose as well as antioxidants in a case-control study.

METHODS

Ninety patients with cataract and 90 age- and sex-matched healthy controls were investigated. Lipid profiles including triglyceride (Tg), total serum cholesterol (Chol) and cholesterol content in high-density lipoproteins (HDL chol) and low-density lipoproteins (LDL chol) as well as fasting glucose (FBS) were measured for all subjects. Plasma oxidative stress as thiobarbituric acid-reactive substances (TBARS) and the status of antioxidants were studied as ferric reducing/antioxidant power (FRAP) and thiol substance assay.

RESULTS

A higher prevalence of abnormal FBS (8.9 vs. 1.1%), Tg (26.7 vs. 8.9%) and Chol (54.4 vs. 30%) was found in cataract patients than the control group (p < 0.05). Plasma Tg (p = 0.02), Chol (p = 0.001) and LDL chol (p = 0.04) were significantly higher in the cataract group than in the control group. Likewise TBARS (p = 0.05) as the level of oxidative stress was significantly higher in the case group, and FRAP (p = 0.03) and thiol (p = 0.02) assays as the antioxidant activity was significantly lower among cataract patients.

CONCLUSION

This study has shown that hypercholesterolaemia, hypertriglyceridaemia, high LDL chol and high FBS are associated with cataract. Also lower plasma antioxidant levels and higher levels of oxidative stress were seen in cataract patients than healthy controls. These findings indicate a need for health promotional activities aimed at controlling these preventable factors among high risk populations.

Authors+Show Affiliations

,

Department of Ophthalmology, Birjand Atherosclerosis and Coronary Artery Research Centre, Birjand University of Medical Sciences, Birjand, Iran.

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Source

The West Indian medical journal 61:3 2012 Jun pg 230-4

MeSH

Antioxidants
Blood Glucose
Case-Control Studies
Cataract
Female
Humans
Lipids
Male
Middle Aged
Oxidative Stress
Thiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23155978

Citation

Heydari, B, et al. "Correlation of Cataract With Serum Lipids, Glucose and Antioxidant Activities: a Case-control Study." The West Indian Medical Journal, vol. 61, no. 3, 2012, pp. 230-4.
Heydari B, Kazemi T, Zarban A, et al. Correlation of cataract with serum lipids, glucose and antioxidant activities: a case-control study. West Indian Med J. 2012;61(3):230-4.
Heydari, B., Kazemi, T., Zarban, A., & Ghahramani, S. (2012). Correlation of cataract with serum lipids, glucose and antioxidant activities: a case-control study. The West Indian Medical Journal, 61(3), pp. 230-4.
Heydari B, et al. Correlation of Cataract With Serum Lipids, Glucose and Antioxidant Activities: a Case-control Study. West Indian Med J. 2012;61(3):230-4. PubMed PMID: 23155978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of cataract with serum lipids, glucose and antioxidant activities: a case-control study. AU - Heydari,B, AU - Kazemi,T, AU - Zarban,A, AU - Ghahramani,S, PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2012/12/12/medline SP - 230 EP - 4 JF - The West Indian medical journal JO - West Indian Med J VL - 61 IS - 3 N2 - OBJECTIVE: The aim of this study is to evaluate the relationship between cataract development and serum lipids, glucose as well as antioxidants in a case-control study. METHODS: Ninety patients with cataract and 90 age- and sex-matched healthy controls were investigated. Lipid profiles including triglyceride (Tg), total serum cholesterol (Chol) and cholesterol content in high-density lipoproteins (HDL chol) and low-density lipoproteins (LDL chol) as well as fasting glucose (FBS) were measured for all subjects. Plasma oxidative stress as thiobarbituric acid-reactive substances (TBARS) and the status of antioxidants were studied as ferric reducing/antioxidant power (FRAP) and thiol substance assay. RESULTS: A higher prevalence of abnormal FBS (8.9 vs. 1.1%), Tg (26.7 vs. 8.9%) and Chol (54.4 vs. 30%) was found in cataract patients than the control group (p < 0.05). Plasma Tg (p = 0.02), Chol (p = 0.001) and LDL chol (p = 0.04) were significantly higher in the cataract group than in the control group. Likewise TBARS (p = 0.05) as the level of oxidative stress was significantly higher in the case group, and FRAP (p = 0.03) and thiol (p = 0.02) assays as the antioxidant activity was significantly lower among cataract patients. CONCLUSION: This study has shown that hypercholesterolaemia, hypertriglyceridaemia, high LDL chol and high FBS are associated with cataract. Also lower plasma antioxidant levels and higher levels of oxidative stress were seen in cataract patients than healthy controls. These findings indicate a need for health promotional activities aimed at controlling these preventable factors among high risk populations. SN - 0043-3144 UR - https://www.unboundmedicine.com/medline/citation/23155978/full_citation L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -