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The effect of acute exhaustive and moderate intensity exercises on nasal cytokine secretion and clinical symptoms in allergic rhinitis patients.
Asian Pac J Allergy Immunol. 2012 Sep; 30(3):185-92.AP

Abstract

BACKGROUND

Allergic rhinitis is an inflammation of the nasal mucosa in response to allergens. There is evidence that exercise can significantly improve personal health and has positive effects on immune function. However, the effects of acute exercise on the inflammatory response and clinical symptoms in patients with allergic rhinitis are still unclear.

PURPOSE

The aim of the present study was to determine the effects of acute exhaustive and moderate exercises on cytokine levels and clinical symptoms in patients with allergic rhinitis.

METHODS

Thirteen allergic rhinitis patients (AR) and 14 healthy subjects (C) were required to complete two running exercise protocols, which included an exhaustive exercise bout using the Bruce protocol performed to exhaustion and moderate exercise performed at 65-70% HRR for 30 minutes. Physiological characteristics, allergic rhinitis symptoms, and cytokine secretions and serum levels were comparatively analyzed before and after each type of exercise.

RESULTS

The total immunoglobulin E levels in the AR group were significantly higher than in C group (p < 0.05). Rhinitis symptoms scores were significantly decreased (p < 0.05) after both exhaustive exercise (7.69 to 1.23 points) and moderate exercise (6.46 to 0.53 points) in the AR group. The ratio of interleukin-2 and interleukin-4 (IL-2/IL-4) in nasal secretions after moderate exercise was significantly higher than those after exhaustive exercise in both the C and AR groups (p < 0.05).

CONCLUSIONS

The data demonstrate that both exhaustive and moderate-intensity exercise resulted in a significant improvement in the symptoms of allergic rhinitis. However, a significantly enhanced IL-2/IL-4 ratio was found following acute moderate exercise intensity. We propose that moderate-intensity exercise is more effective than exhaustive exercise in enhancing immune function for allergic rhinitis patients.

Authors+Show Affiliations

Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23156847

Citation

Tongtako, Wannaporn, et al. "The Effect of Acute Exhaustive and Moderate Intensity Exercises On Nasal Cytokine Secretion and Clinical Symptoms in Allergic Rhinitis Patients." Asian Pacific Journal of Allergy and Immunology, vol. 30, no. 3, 2012, pp. 185-92.
Tongtako W, Klaewsongkram J, Jaronsukwimal N, et al. The effect of acute exhaustive and moderate intensity exercises on nasal cytokine secretion and clinical symptoms in allergic rhinitis patients. Asian Pac J Allergy Immunol. 2012;30(3):185-92.
Tongtako, W., Klaewsongkram, J., Jaronsukwimal, N., Buranapraditkun, S., Mickleborough, T. D., & Suksom, D. (2012). The effect of acute exhaustive and moderate intensity exercises on nasal cytokine secretion and clinical symptoms in allergic rhinitis patients. Asian Pacific Journal of Allergy and Immunology, 30(3), 185-92.
Tongtako W, et al. The Effect of Acute Exhaustive and Moderate Intensity Exercises On Nasal Cytokine Secretion and Clinical Symptoms in Allergic Rhinitis Patients. Asian Pac J Allergy Immunol. 2012;30(3):185-92. PubMed PMID: 23156847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of acute exhaustive and moderate intensity exercises on nasal cytokine secretion and clinical symptoms in allergic rhinitis patients. AU - Tongtako,Wannaporn, AU - Klaewsongkram,Jettanong, AU - Jaronsukwimal,Nutdanai, AU - Buranapraditkun,Supranee, AU - Mickleborough,Timothy D, AU - Suksom,Daroonwan, PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2013/2/6/medline SP - 185 EP - 92 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac. J. Allergy Immunol. VL - 30 IS - 3 N2 - BACKGROUND: Allergic rhinitis is an inflammation of the nasal mucosa in response to allergens. There is evidence that exercise can significantly improve personal health and has positive effects on immune function. However, the effects of acute exercise on the inflammatory response and clinical symptoms in patients with allergic rhinitis are still unclear. PURPOSE: The aim of the present study was to determine the effects of acute exhaustive and moderate exercises on cytokine levels and clinical symptoms in patients with allergic rhinitis. METHODS: Thirteen allergic rhinitis patients (AR) and 14 healthy subjects (C) were required to complete two running exercise protocols, which included an exhaustive exercise bout using the Bruce protocol performed to exhaustion and moderate exercise performed at 65-70% HRR for 30 minutes. Physiological characteristics, allergic rhinitis symptoms, and cytokine secretions and serum levels were comparatively analyzed before and after each type of exercise. RESULTS: The total immunoglobulin E levels in the AR group were significantly higher than in C group (p < 0.05). Rhinitis symptoms scores were significantly decreased (p < 0.05) after both exhaustive exercise (7.69 to 1.23 points) and moderate exercise (6.46 to 0.53 points) in the AR group. The ratio of interleukin-2 and interleukin-4 (IL-2/IL-4) in nasal secretions after moderate exercise was significantly higher than those after exhaustive exercise in both the C and AR groups (p < 0.05). CONCLUSIONS: The data demonstrate that both exhaustive and moderate-intensity exercise resulted in a significant improvement in the symptoms of allergic rhinitis. However, a significantly enhanced IL-2/IL-4 ratio was found following acute moderate exercise intensity. We propose that moderate-intensity exercise is more effective than exhaustive exercise in enhancing immune function for allergic rhinitis patients. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/23156847/The_effect_of_acute_exhaustive_and_moderate_intensity_exercises_on_nasal_cytokine_secretion_and_clinical_symptoms_in_allergic_rhinitis_patients_ L2 - http://apjai-journal.org/wp-content/uploads/2017/12/3TheeffectofacuteexhaustiveVol30No3September2012P185.pdf DB - PRIME DP - Unbound Medicine ER -