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Effect of seasonality on chemical composition and antibacterial and anticandida activities of Argentine propolis. Design of a topical formulation.
Nat Prod Commun 2012; 7(10):1315-8NP

Abstract

The effect of seasonality on Argentine propolis collected during one year on its phenolic and flavonoid content and on the growth of Gram-positive and Gram-negative antibiotic resistant bacteria and Candida species was evaluated. Extracts of propolis samples collected in the summer and spring showed higher phenolic and flavonoid contents than the samples collected in other seasons (5.86 to 6.06 mg GAE/mL and 3.77 to 4.23 mg QE/mL, respectively). The propolis collected in summer and autumn showed higher antibacterial activity (30 microg/mL) than the other samples (MIC values between 30 and 120 microg/mL). No antibacterial activity was detected against Gram-negative bacteria. Also, these extracts were able to inhibit the development of five Candida species, with MFC values of 15-120 microg/mL. Pharmaceutical formulations containing the more active propolis extract were prepared. The hydrogel of acrylic acid polymer containing summer propolis extract as an antimicrobial agent showed microbiological, physical and functional stability during storage for 180 days. The pharmaceutical preparation, as well as the propolis extracts, was active against Candida sp. and antibiotic-multi-resistant Gram-positive bacteria. These results reveal that propolis samples collected by scraping in four seasons, especially in summer in Calingasta, San Juan, Argentina, can be used to obtain tinctures and hydrogels with antibacterial and antimycotic potential for topical use.

Authors+Show Affiliations

INQUINOA (CONICET), Universidad Nacional de Tucumán, Ayacucho 471. T4000INI- San Miguel de Tucumán, Tucumán, Argentina. misla@tucbbs.com.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23156997

Citation

Isla, María Inés, et al. "Effect of Seasonality On Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation." Natural Product Communications, vol. 7, no. 10, 2012, pp. 1315-8.
Isla MI, Dantur Y, Salas A, et al. Effect of seasonality on chemical composition and antibacterial and anticandida activities of Argentine propolis. Design of a topical formulation. Nat Prod Commun. 2012;7(10):1315-8.
Isla, M. I., Dantur, Y., Salas, A., Danert, C., Zampini, C., Arias, M., ... Nieva Moreno, M. I. (2012). Effect of seasonality on chemical composition and antibacterial and anticandida activities of Argentine propolis. Design of a topical formulation. Natural Product Communications, 7(10), pp. 1315-8.
Isla MI, et al. Effect of Seasonality On Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation. Nat Prod Commun. 2012;7(10):1315-8. PubMed PMID: 23156997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of seasonality on chemical composition and antibacterial and anticandida activities of Argentine propolis. Design of a topical formulation. AU - Isla,María Inés, AU - Dantur,Yanina, AU - Salas,Ana, AU - Danert,Carolina, AU - Zampini,Catiana, AU - Arias,Myriam, AU - Ordóñez,Roxana, AU - Maldonado,Luis, AU - Bedascarrasbure,Enrique, AU - Nieva Moreno,María Inés, PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2012/12/29/medline SP - 1315 EP - 8 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 10 N2 - The effect of seasonality on Argentine propolis collected during one year on its phenolic and flavonoid content and on the growth of Gram-positive and Gram-negative antibiotic resistant bacteria and Candida species was evaluated. Extracts of propolis samples collected in the summer and spring showed higher phenolic and flavonoid contents than the samples collected in other seasons (5.86 to 6.06 mg GAE/mL and 3.77 to 4.23 mg QE/mL, respectively). The propolis collected in summer and autumn showed higher antibacterial activity (30 microg/mL) than the other samples (MIC values between 30 and 120 microg/mL). No antibacterial activity was detected against Gram-negative bacteria. Also, these extracts were able to inhibit the development of five Candida species, with MFC values of 15-120 microg/mL. Pharmaceutical formulations containing the more active propolis extract were prepared. The hydrogel of acrylic acid polymer containing summer propolis extract as an antimicrobial agent showed microbiological, physical and functional stability during storage for 180 days. The pharmaceutical preparation, as well as the propolis extracts, was active against Candida sp. and antibiotic-multi-resistant Gram-positive bacteria. These results reveal that propolis samples collected by scraping in four seasons, especially in summer in Calingasta, San Juan, Argentina, can be used to obtain tinctures and hydrogels with antibacterial and antimycotic potential for topical use. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/23156997/Effect_of_seasonality_on_chemical_composition_and_antibacterial_and_anticandida_activities_of_Argentine_propolis__Design_of_a_topical_formulation_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -