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Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study.
Biol Psychiatry. 2013 Jan 15; 73(2):194-201.BP

Abstract

BACKGROUND

White matter microstructural changes detected using diffusion tensor imaging have been reported in bipolar disorder. However, findings are heterogeneous, which may be related to the use of analysis techniques that cannot adequately model crossing fibers in the brain. We therefore sought to identify altered diffusion anisotropy and diffusivity changes using an improved high angular resolution fiber-tracking technique.

METHODS

Diffusion magnetic resonance imaging data was obtained from 35 prospectively confirmed euthymic bipolar disorder type 1 patients (age 22-59) and 43 control subjects (age 22-59) drawn from a sample of 120 age- and gender-matched demographically similar case-control pairs. Tractography using a constrained spherical deconvolution approach to account for crossing fibers was implemented. Changes in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity between patient and control groups in subdivisions of the corpus callosum, cingulum, and fornix were measured as indicators of trait differences in white matter microstructural organization in bipolar disorder.

RESULTS

Patients had significantly reduced fractional anisotropy and increased mean diffusivity and radial diffusivity in all divisions of the corpus callosum, left fornix, and subgenual cingulum compared with control subjects. Axial diffusivity was increased in the fornix bilaterally and right dorsal-anterior cingulum.

CONCLUSIONS

By using an improved fiber-tracking method in a clinically homogeneous population, we were able to localize trait diffusivity changes to specific subdivisions of limbic fiber pathways, including the fornix. Our findings extend previous reports of altered limbic system microstructural disorganization as a trait feature of bipolar disorder.

Authors+Show Affiliations

Department of Radiology, University Hospital of the KU Leuven, Radiology/MIRC, UZ Herestraat 49, Box 7003, Leuven 3000, Belgium. louise.emsell@med.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23158457

Citation

Emsell, Louise, et al. "Limbic and Callosal White Matter Changes in Euthymic Bipolar I Disorder: an Advanced Diffusion Magnetic Resonance Imaging Tractography Study." Biological Psychiatry, vol. 73, no. 2, 2013, pp. 194-201.
Emsell L, Leemans A, Langan C, et al. Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study. Biol Psychiatry. 2013;73(2):194-201.
Emsell, L., Leemans, A., Langan, C., Van Hecke, W., Barker, G. J., McCarthy, P., Jeurissen, B., Sijbers, J., Sunaert, S., Cannon, D. M., & McDonald, C. (2013). Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study. Biological Psychiatry, 73(2), 194-201. https://doi.org/10.1016/j.biopsych.2012.09.023
Emsell L, et al. Limbic and Callosal White Matter Changes in Euthymic Bipolar I Disorder: an Advanced Diffusion Magnetic Resonance Imaging Tractography Study. Biol Psychiatry. 2013 Jan 15;73(2):194-201. PubMed PMID: 23158457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study. AU - Emsell,Louise, AU - Leemans,Alexander, AU - Langan,Camilla, AU - Van Hecke,Wim, AU - Barker,Gareth J, AU - McCarthy,Peter, AU - Jeurissen,Ben, AU - Sijbers,Jan, AU - Sunaert,Stefan, AU - Cannon,Dara M, AU - McDonald,Colm, Y1 - 2012/11/13/ PY - 2012/04/03/received PY - 2012/09/21/revised PY - 2012/09/21/accepted PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2013/6/7/medline SP - 194 EP - 201 JF - Biological psychiatry JO - Biol. Psychiatry VL - 73 IS - 2 N2 - BACKGROUND: White matter microstructural changes detected using diffusion tensor imaging have been reported in bipolar disorder. However, findings are heterogeneous, which may be related to the use of analysis techniques that cannot adequately model crossing fibers in the brain. We therefore sought to identify altered diffusion anisotropy and diffusivity changes using an improved high angular resolution fiber-tracking technique. METHODS: Diffusion magnetic resonance imaging data was obtained from 35 prospectively confirmed euthymic bipolar disorder type 1 patients (age 22-59) and 43 control subjects (age 22-59) drawn from a sample of 120 age- and gender-matched demographically similar case-control pairs. Tractography using a constrained spherical deconvolution approach to account for crossing fibers was implemented. Changes in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity between patient and control groups in subdivisions of the corpus callosum, cingulum, and fornix were measured as indicators of trait differences in white matter microstructural organization in bipolar disorder. RESULTS: Patients had significantly reduced fractional anisotropy and increased mean diffusivity and radial diffusivity in all divisions of the corpus callosum, left fornix, and subgenual cingulum compared with control subjects. Axial diffusivity was increased in the fornix bilaterally and right dorsal-anterior cingulum. CONCLUSIONS: By using an improved fiber-tracking method in a clinically homogeneous population, we were able to localize trait diffusivity changes to specific subdivisions of limbic fiber pathways, including the fornix. Our findings extend previous reports of altered limbic system microstructural disorganization as a trait feature of bipolar disorder. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/23158457/Limbic_and_callosal_white_matter_changes_in_euthymic_bipolar_I_disorder:_an_advanced_diffusion_magnetic_resonance_imaging_tractography_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(12)00849-9 DB - PRIME DP - Unbound Medicine ER -