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Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding.
Clin Nutr. 2013 Apr; 32(2):162-71.CN

Abstract

Intestinal failure (IF) is a well identified clinical condition, which is characterised by the reduction of functional gut capacity below the minimum needed for adequate digestion and absorption of nutrients for normal growth in children. Short bowel syndrome (SBS) is the leading cause of IF in neonates, infants and young children usually as a result of extensive intestinal resection during the neonatal period. Simultaneously maintaining optimal nutritional status and achieving intestinal adaptation is a clinical challenge in short bowel patients. Both growth and development of the child as well as gut adaptation should be considered synergistically as primary outcome parameters. Enteral nutrition (EN) can be introduced orally and/or by tube feeding (TF). Several controversies over nutritional treatment of children with SBS related intestinal failure remain. As reported from different centres around the world, most practices are more "experienced based" rather than "evidence based". This is partly due to the small number of patients with this condition. This review (based on a consensus) discusses the physiological principles and nutritional management, including the type of diet and route of delivery. Perspectives in optimizing intestinal adaptation and reducing the consequences of small intestinal bacterial overgrowth are also discussed.

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Authors+Show Affiliations

Goulet O
Department of Pediatric Gastroenterology-Hepatology and Nutrition, Reference Center for Rare Digestive Diseases, Intestinal Failure Rehabilitation Center, Hôpital Necker-Enfants Malades, University of Paris Descartes, France. Olivier.goulet@nck.aphp.fr
Olieman J
No affiliation info available
Ksiazyk J
No affiliation info available
Spolidoro J
No affiliation info available
Tibboe D
No affiliation info available
Köhler H
No affiliation info available
Yagci RV
No affiliation info available
Falconer J
No affiliation info available
Grimble G
No affiliation info available
Beattie RM
No affiliation info available

MeSH

Adaptation, PhysiologicalChild, PreschoolDietDietary CarbohydratesDietary FatsDietary FiberDietary ProteinsEnteral NutritionFatty Acids, UnsaturatedHumansInfantInfant, NewbornIntestine, SmallNutritional StatusProbioticsShort Bowel Syndrome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23159212

Clinical Trial Links

Pectin Use in Pediatric Intestinal Rehabilitation

Citation

Goulet, O, et al. "Neonatal Short Bowel Syndrome as a Model of Intestinal Failure: Physiological Background for Enteral Feeding." Clinical Nutrition (Edinburgh, Scotland), vol. 32, no. 2, 2013, pp. 162-71.
Goulet O, Olieman J, Ksiazyk J, et al. Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding. Clin Nutr. 2013;32(2):162-71.
Goulet, O., Olieman, J., Ksiazyk, J., Spolidoro, J., Tibboe, D., Köhler, H., Yagci, R. V., Falconer, J., Grimble, G., & Beattie, R. M. (2013). Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding. Clinical Nutrition (Edinburgh, Scotland), 32(2), 162-71. https://doi.org/10.1016/j.clnu.2012.09.007
Goulet O, et al. Neonatal Short Bowel Syndrome as a Model of Intestinal Failure: Physiological Background for Enteral Feeding. Clin Nutr. 2013;32(2):162-71. PubMed PMID: 23159212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding. AU - Goulet,O, AU - Olieman,J, AU - Ksiazyk,J, AU - Spolidoro,J, AU - Tibboe,D, AU - Köhler,H, AU - Yagci,R Vural, AU - Falconer,J, AU - Grimble,G, AU - Beattie,R M, Y1 - 2012/09/25/ PY - 2012/02/26/received PY - 2012/08/26/revised PY - 2012/09/12/accepted PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2013/9/24/medline SP - 162 EP - 71 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 32 IS - 2 N2 - Intestinal failure (IF) is a well identified clinical condition, which is characterised by the reduction of functional gut capacity below the minimum needed for adequate digestion and absorption of nutrients for normal growth in children. Short bowel syndrome (SBS) is the leading cause of IF in neonates, infants and young children usually as a result of extensive intestinal resection during the neonatal period. Simultaneously maintaining optimal nutritional status and achieving intestinal adaptation is a clinical challenge in short bowel patients. Both growth and development of the child as well as gut adaptation should be considered synergistically as primary outcome parameters. Enteral nutrition (EN) can be introduced orally and/or by tube feeding (TF). Several controversies over nutritional treatment of children with SBS related intestinal failure remain. As reported from different centres around the world, most practices are more "experienced based" rather than "evidence based". This is partly due to the small number of patients with this condition. This review (based on a consensus) discusses the physiological principles and nutritional management, including the type of diet and route of delivery. Perspectives in optimizing intestinal adaptation and reducing the consequences of small intestinal bacterial overgrowth are also discussed. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/23159212/Neonatal_short_bowel_syndrome_as_a_model_of_intestinal_failure:_physiological_background_for_enteral_feeding_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(12)00211-7 DB - PRIME DP - Unbound Medicine ER -