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Phylogenetic distribution of protease inhibitors of the Kazal-family within the Arthropoda.
Peptides. 2013 Mar; 41:59-65.P

Abstract

In mammalian pancreatic cells, the pancreatic secretory trypsin inhibitor (PSTI) belonging to the Kazal-family prevents the premature activation of digestive enzymes and thus plays an important role in a protective mechanism against tissue destruction by autophagy. Although a similar protective mechanism exists in Arthropoda, the distribution of these inhibitors in this phylum remains obscure. A comprehensive in silico search of nucleotide databases, revealed the presence of members of the Kazal-family in the four major subphyla of the Arthropoda. Especially in the Hexapoda and the Crustacea these inhibitors are widespread, while in the Chelicerata and Myriapoda only a few Kazal-like protease inhibitors were found. A sequence alignment of inhibitors retrieved in the digestive system of insects revealed a conservation of the PSTI characteristics and strong resemblance to vertebrate PSTI. A phylogenetic analysis of these inhibitors showed that they generally cluster according to their order. The results of this data mining study provide new evidence for the existence of an ancient protective mechanism in metazoan digestive systems. Kazal-like inhibitors, which play an important protective role in the pancreas of vertebrates, also seem to be present in Arthropoda.

Authors+Show Affiliations

Department of Animal Physiology and Neurobiology, Zoological Institute KU Leuven, Leuven, Belgium. Vincent.vanHoef@bio.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23159789

Citation

van Hoef, Vincent, et al. "Phylogenetic Distribution of Protease Inhibitors of the Kazal-family Within the Arthropoda." Peptides, vol. 41, 2013, pp. 59-65.
van Hoef V, Breugelmans B, Spit J, et al. Phylogenetic distribution of protease inhibitors of the Kazal-family within the Arthropoda. Peptides. 2013;41:59-65.
van Hoef, V., Breugelmans, B., Spit, J., Simonet, G., Zels, S., & Vanden Broeck, J. (2013). Phylogenetic distribution of protease inhibitors of the Kazal-family within the Arthropoda. Peptides, 41, 59-65. https://doi.org/10.1016/j.peptides.2012.10.015
van Hoef V, et al. Phylogenetic Distribution of Protease Inhibitors of the Kazal-family Within the Arthropoda. Peptides. 2013;41:59-65. PubMed PMID: 23159789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phylogenetic distribution of protease inhibitors of the Kazal-family within the Arthropoda. AU - van Hoef,Vincent, AU - Breugelmans,Bert, AU - Spit,Jornt, AU - Simonet,Gert, AU - Zels,Sven, AU - Vanden Broeck,Jozef, Y1 - 2012/11/15/ PY - 2012/05/29/received PY - 2012/10/30/revised PY - 2012/10/30/accepted PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2013/12/16/medline SP - 59 EP - 65 JF - Peptides JO - Peptides VL - 41 N2 - In mammalian pancreatic cells, the pancreatic secretory trypsin inhibitor (PSTI) belonging to the Kazal-family prevents the premature activation of digestive enzymes and thus plays an important role in a protective mechanism against tissue destruction by autophagy. Although a similar protective mechanism exists in Arthropoda, the distribution of these inhibitors in this phylum remains obscure. A comprehensive in silico search of nucleotide databases, revealed the presence of members of the Kazal-family in the four major subphyla of the Arthropoda. Especially in the Hexapoda and the Crustacea these inhibitors are widespread, while in the Chelicerata and Myriapoda only a few Kazal-like protease inhibitors were found. A sequence alignment of inhibitors retrieved in the digestive system of insects revealed a conservation of the PSTI characteristics and strong resemblance to vertebrate PSTI. A phylogenetic analysis of these inhibitors showed that they generally cluster according to their order. The results of this data mining study provide new evidence for the existence of an ancient protective mechanism in metazoan digestive systems. Kazal-like inhibitors, which play an important protective role in the pancreas of vertebrates, also seem to be present in Arthropoda. SN - 1873-5169 UR - https://www.unboundmedicine.com/medline/citation/23159789/Phylogenetic_distribution_of_protease_inhibitors_of_the_Kazal_family_within_the_Arthropoda_ DB - PRIME DP - Unbound Medicine ER -