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Effects of different doses of alkaline citrate on urine composition and crystallization of calcium oxalate.
Urol Res 1990; 18(1):13-6UR

Abstract

Prophylactic treatment with alkaline citrate in patients with recurrent calcium oxalate (CaOx) stone disease results in reduced CaOx supersaturation and increased urinary citrate. The effects of a single evening dose were compared with those of two and three daily doses in six recurrent CaOx stone formers with hypercalciuria, hypocitraturia or raised calcium/citrate quotients. While on a standardized hospital diet the patients were given 7.5 g (28 mmol) of sodium potassium citrate (URALYT-U) in one, two, and three doses. Fractional urine collections during 24 hours were analyzed for pH, composition, and crystallization risk (CR). All dosage regimens had favourable effects on urinary calcium, citrate, calcium/citrate quotients, and CaOx-CR. The most sustained effect was recorded with three divided doses. Single evening doses resulted in the most pronounced effects between 22.00-06.00 h, thereby counteracting the increased risk of CaOx crystallization during that period. In terms of 24h urine composition the best effect was recorded with alkaline citrate administered three times daily, but because of the favourable response by a single evening dose between 22.00-06.00 h the assumption was made that this dosage regimen might be sufficient to reduce the risk of CaOx crystallization and stone formation. However, the validity of such an assumption can only be established by long-term clinical studies.

Authors+Show Affiliations

Department of Urology, University Hospital, Linköping, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2316066

Citation

Berg, C, et al. "Effects of Different Doses of Alkaline Citrate On Urine Composition and Crystallization of Calcium Oxalate." Urological Research, vol. 18, no. 1, 1990, pp. 13-6.
Berg C, Larsson L, Tiselius HG. Effects of different doses of alkaline citrate on urine composition and crystallization of calcium oxalate. Urol Res. 1990;18(1):13-6.
Berg, C., Larsson, L., & Tiselius, H. G. (1990). Effects of different doses of alkaline citrate on urine composition and crystallization of calcium oxalate. Urological Research, 18(1), pp. 13-6.
Berg C, Larsson L, Tiselius HG. Effects of Different Doses of Alkaline Citrate On Urine Composition and Crystallization of Calcium Oxalate. Urol Res. 1990;18(1):13-6. PubMed PMID: 2316066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of different doses of alkaline citrate on urine composition and crystallization of calcium oxalate. AU - Berg,C, AU - Larsson,L, AU - Tiselius,H G, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 13 EP - 6 JF - Urological research JO - Urol. Res. VL - 18 IS - 1 N2 - Prophylactic treatment with alkaline citrate in patients with recurrent calcium oxalate (CaOx) stone disease results in reduced CaOx supersaturation and increased urinary citrate. The effects of a single evening dose were compared with those of two and three daily doses in six recurrent CaOx stone formers with hypercalciuria, hypocitraturia or raised calcium/citrate quotients. While on a standardized hospital diet the patients were given 7.5 g (28 mmol) of sodium potassium citrate (URALYT-U) in one, two, and three doses. Fractional urine collections during 24 hours were analyzed for pH, composition, and crystallization risk (CR). All dosage regimens had favourable effects on urinary calcium, citrate, calcium/citrate quotients, and CaOx-CR. The most sustained effect was recorded with three divided doses. Single evening doses resulted in the most pronounced effects between 22.00-06.00 h, thereby counteracting the increased risk of CaOx crystallization during that period. In terms of 24h urine composition the best effect was recorded with alkaline citrate administered three times daily, but because of the favourable response by a single evening dose between 22.00-06.00 h the assumption was made that this dosage regimen might be sufficient to reduce the risk of CaOx crystallization and stone formation. However, the validity of such an assumption can only be established by long-term clinical studies. SN - 0300-5623 UR - https://www.unboundmedicine.com/medline/citation/2316066/Effects_of_different_doses_of_alkaline_citrate_on_urine_composition_and_crystallization_of_calcium_oxalate_ DB - PRIME DP - Unbound Medicine ER -