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Mucocele-like lesions diagnosed on breast core biopsy: assessment of upgrade rate and need for surgical excision.
Am J Clin Pathol. 2012 Dec; 138(6):783-8.AJ

Abstract

Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings with those of excision pathology. Thirty-eight patients underwent surgical excision and 29 were benign (76%), 4 had atypical ductal hyperplasia (11%), and 5 had ductal carcinoma in situ (13%), with an overall upgrade rate of 13%. However, the risk of upgrade was exclusively associated with the presence of atypia as seen on the needle core biopsy. All 22 MLLs without atypia had benign excisions, while 5 (31%) of the 16 patients with MLLs with atypia were upgraded to ductal carcinoma in situ on excision. No invasive carcinoma was identified. We believe it is reasonable that women with the core biopsy diagnosis of MLL without atypia and no associated mass be offered close clinical follow-up as an alternative to surgery.

Authors+Show Affiliations

Dept of Pathology, Northwestern University Feinberg School of Medicine,Chicago IL 60611, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23161710

Citation

Sutton, Brian, et al. "Mucocele-like Lesions Diagnosed On Breast Core Biopsy: Assessment of Upgrade Rate and Need for Surgical Excision." American Journal of Clinical Pathology, vol. 138, no. 6, 2012, pp. 783-8.
Sutton B, Davion S, Feldman M, et al. Mucocele-like lesions diagnosed on breast core biopsy: assessment of upgrade rate and need for surgical excision. Am J Clin Pathol. 2012;138(6):783-8.
Sutton, B., Davion, S., Feldman, M., Siziopikou, K., Mendelson, E., & Sullivan, M. (2012). Mucocele-like lesions diagnosed on breast core biopsy: assessment of upgrade rate and need for surgical excision. American Journal of Clinical Pathology, 138(6), 783-8. https://doi.org/10.1309/AJCP1D8YLCFFTLOW
Sutton B, et al. Mucocele-like Lesions Diagnosed On Breast Core Biopsy: Assessment of Upgrade Rate and Need for Surgical Excision. Am J Clin Pathol. 2012;138(6):783-8. PubMed PMID: 23161710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucocele-like lesions diagnosed on breast core biopsy: assessment of upgrade rate and need for surgical excision. AU - Sutton,Brian, AU - Davion,Simone, AU - Feldman,Marina, AU - Siziopikou,Kalliopi, AU - Mendelson,Ellen, AU - Sullivan,Megan, PY - 2012/11/20/entrez PY - 2012/11/20/pubmed PY - 2013/1/29/medline SP - 783 EP - 8 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 138 IS - 6 N2 - Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings with those of excision pathology. Thirty-eight patients underwent surgical excision and 29 were benign (76%), 4 had atypical ductal hyperplasia (11%), and 5 had ductal carcinoma in situ (13%), with an overall upgrade rate of 13%. However, the risk of upgrade was exclusively associated with the presence of atypia as seen on the needle core biopsy. All 22 MLLs without atypia had benign excisions, while 5 (31%) of the 16 patients with MLLs with atypia were upgraded to ductal carcinoma in situ on excision. No invasive carcinoma was identified. We believe it is reasonable that women with the core biopsy diagnosis of MLL without atypia and no associated mass be offered close clinical follow-up as an alternative to surgery. SN - 1943-7722 UR - https://www.unboundmedicine.com/medline/citation/23161710/Mucocele_like_lesions_diagnosed_on_breast_core_biopsy:_assessment_of_upgrade_rate_and_need_for_surgical_excision_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/AJCP1D8YLCFFTLOW DB - PRIME DP - Unbound Medicine ER -