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Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release.
Drug Dev Ind Pharm. 2013 Nov; 39(11):1802-8.DD

Abstract

CONTEXT

Continuous processing is becoming popular in the pharmaceutical industry for its cost and quality advantages.

OBJECTIVE

This study evaluated the mechanical properties, uniformity of dosage units and drug release from the tablets prepared by continuous direct compression process.

MATERIALS AND METHODS

The tablet formulations consisted of acetaminophen (3-30% (w/w)) pre-blended with 0.25% (w/w) colloidal silicon dioxide, microcrystalline cellulose (69-96% (w/w)) and magnesium stearate (1% (w/w)). The continuous tableting line consisted of three loss-in-weight feeders and a convective continuous mixer and a rotary tablet press. The process continued for 8 min and steady state was reached within 5 min. The effects of acetaminophen content, impeller rotation rate (39-254 rpm) and total feed rate (15 and 20 kg/h) on tablet properties were examined.

RESULTS AND DISCUSSION

All the tablets complied with the friability requirements of European Pharmacopoeia and rapidly released acetaminophen. However, the relative standard deviation of acetaminophen content (10% (w/w)) increased with an increase in impeller rotation rate at a constant total feed rate (20 kg/h). A compression force of 12 kN tended to result in greater tablet hardness and subsequently a slower initial acetaminophen release from tablets when compared with those made with the compression force of about 8 kN.

CONCLUSIONS

In conclusion, tablets could be successfully prepared by a continuous direct compression process and process conditions affected to some extent tablet properties.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Järvinen MA
School of Pharmacy, University of Eastern Finland , Kuopio , Finland.
Paaso J
No affiliation info available
Paavola M
No affiliation info available
Leiviskä K
No affiliation info available
Juuti M
No affiliation info available
Muzzio F
No affiliation info available
Järvinen K
No affiliation info available

MeSH

AcetaminophenAnalgesics, Non-NarcoticAutomationCelluloseChemical PhenomenaColloidsDrug CompoundingExcipientsFinlandHardnessKineticsMechanical PhenomenaModels, MolecularQuality ControlSilicon DioxideSolubilityStearic AcidsTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23163644

Citation

Järvinen, Maiju A., et al. "Continuous Direct Tablet Compression: Effects of Impeller Rotation Rate, Total Feed Rate and Drug Content On the Tablet Properties and Drug Release." Drug Development and Industrial Pharmacy, vol. 39, no. 11, 2013, pp. 1802-8.
Järvinen MA, Paaso J, Paavola M, et al. Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. Drug Dev Ind Pharm. 2013;39(11):1802-8.
Järvinen, M. A., Paaso, J., Paavola, M., Leiviskä, K., Juuti, M., Muzzio, F., & Järvinen, K. (2013). Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. Drug Development and Industrial Pharmacy, 39(11), 1802-8. https://doi.org/10.3109/03639045.2012.738681
Järvinen MA, et al. Continuous Direct Tablet Compression: Effects of Impeller Rotation Rate, Total Feed Rate and Drug Content On the Tablet Properties and Drug Release. Drug Dev Ind Pharm. 2013;39(11):1802-8. PubMed PMID: 23163644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. AU - Järvinen,Maiju A, AU - Paaso,Janne, AU - Paavola,Marko, AU - Leiviskä,Kauko, AU - Juuti,Mikko, AU - Muzzio,Fernando, AU - Järvinen,Kristiina, Y1 - 2012/11/19/ PY - 2012/11/21/entrez PY - 2012/11/21/pubmed PY - 2014/5/16/medline SP - 1802 EP - 8 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 39 IS - 11 N2 - CONTEXT: Continuous processing is becoming popular in the pharmaceutical industry for its cost and quality advantages. OBJECTIVE: This study evaluated the mechanical properties, uniformity of dosage units and drug release from the tablets prepared by continuous direct compression process. MATERIALS AND METHODS: The tablet formulations consisted of acetaminophen (3-30% (w/w)) pre-blended with 0.25% (w/w) colloidal silicon dioxide, microcrystalline cellulose (69-96% (w/w)) and magnesium stearate (1% (w/w)). The continuous tableting line consisted of three loss-in-weight feeders and a convective continuous mixer and a rotary tablet press. The process continued for 8 min and steady state was reached within 5 min. The effects of acetaminophen content, impeller rotation rate (39-254 rpm) and total feed rate (15 and 20 kg/h) on tablet properties were examined. RESULTS AND DISCUSSION: All the tablets complied with the friability requirements of European Pharmacopoeia and rapidly released acetaminophen. However, the relative standard deviation of acetaminophen content (10% (w/w)) increased with an increase in impeller rotation rate at a constant total feed rate (20 kg/h). A compression force of 12 kN tended to result in greater tablet hardness and subsequently a slower initial acetaminophen release from tablets when compared with those made with the compression force of about 8 kN. CONCLUSIONS: In conclusion, tablets could be successfully prepared by a continuous direct compression process and process conditions affected to some extent tablet properties. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/23163644/Continuous_direct_tablet_compression:_effects_of_impeller_rotation_rate_total_feed_rate_and_drug_content_on_the_tablet_properties_and_drug_release_ DB - PRIME DP - Unbound Medicine ER -