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Influence of uracil on bacterial translocation in an intestinal obstruction model in rats.
Int J Surg. 2013; 11(1):27-30.IJ

Abstract

INTRODUCTION

Bacterial translocation occurs when intestinal mucosa and the intestinal wall lose their barrier properties against bacteria such as in the case of intestinal obstruction. Enteral nutrition with immunonutrients strengthens the immune system and thickens the intestinal barrier thus preventing bacterial translocation.

AIM

The purpose of this study is to investigate the effect of uracil which is an immunonutrient on bacterial translocation using rats with intestinal obstruction as a model.

METHODS

Wistar albino rats were divided into three groups. The control group was fed with standard chow diet, while the other two groups were fed with uracil-supplemented chow diet. The rats were fed with these diets for seven days. And the end of the feeding period all groups were submitted intestinal obstruction and injected with (99m)Tc labeled Escherichia coli into the rats' terminal ileum under anesthetic. The rats were sacrificed 24 h later. Their blood, mesenteric lymph nodes (MLN), liver, spleen, lung and ileum were removed to determine level of radioactivity.

RESULTS

When compared with the control group it was determined that uracil supplementation reduced the level of bacterial translocation.

CONCLUSION

Uracil may be used in the prevention of bacterial translocation in cases of intestinal obstruction because it strengthens the intestinal barrier and the immune system. However, more studies are needed to clearly explain the mechanism behind uracil's beneficial role here.

Authors+Show Affiliations

Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Bornova, 35100 Izmir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23164988

Citation

Çıtak, Aslı, et al. "Influence of Uracil On Bacterial Translocation in an Intestinal Obstruction Model in Rats." International Journal of Surgery (London, England), vol. 11, no. 1, 2013, pp. 27-30.
Çıtak A, Yilmaz O, Pekçetin Ç, et al. Influence of uracil on bacterial translocation in an intestinal obstruction model in rats. Int J Surg. 2013;11(1):27-30.
Çıtak, A., Yilmaz, O., Pekçetin, Ç., Ozbal, S., & Lambrecht, F. Y. (2013). Influence of uracil on bacterial translocation in an intestinal obstruction model in rats. International Journal of Surgery (London, England), 11(1), 27-30. https://doi.org/10.1016/j.ijsu.2012.11.003
Çıtak A, et al. Influence of Uracil On Bacterial Translocation in an Intestinal Obstruction Model in Rats. Int J Surg. 2013;11(1):27-30. PubMed PMID: 23164988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of uracil on bacterial translocation in an intestinal obstruction model in rats. AU - Çıtak,Aslı, AU - Yilmaz,Osman, AU - Pekçetin,Çetin, AU - Ozbal,Seda, AU - Lambrecht,Fatma Yurt, Y1 - 2012/11/16/ PY - 2012/05/30/received PY - 2012/10/02/revised PY - 2012/11/09/accepted PY - 2012/11/21/entrez PY - 2012/11/21/pubmed PY - 2013/7/25/medline SP - 27 EP - 30 JF - International journal of surgery (London, England) JO - Int J Surg VL - 11 IS - 1 N2 - INTRODUCTION: Bacterial translocation occurs when intestinal mucosa and the intestinal wall lose their barrier properties against bacteria such as in the case of intestinal obstruction. Enteral nutrition with immunonutrients strengthens the immune system and thickens the intestinal barrier thus preventing bacterial translocation. AIM: The purpose of this study is to investigate the effect of uracil which is an immunonutrient on bacterial translocation using rats with intestinal obstruction as a model. METHODS: Wistar albino rats were divided into three groups. The control group was fed with standard chow diet, while the other two groups were fed with uracil-supplemented chow diet. The rats were fed with these diets for seven days. And the end of the feeding period all groups were submitted intestinal obstruction and injected with (99m)Tc labeled Escherichia coli into the rats' terminal ileum under anesthetic. The rats were sacrificed 24 h later. Their blood, mesenteric lymph nodes (MLN), liver, spleen, lung and ileum were removed to determine level of radioactivity. RESULTS: When compared with the control group it was determined that uracil supplementation reduced the level of bacterial translocation. CONCLUSION: Uracil may be used in the prevention of bacterial translocation in cases of intestinal obstruction because it strengthens the intestinal barrier and the immune system. However, more studies are needed to clearly explain the mechanism behind uracil's beneficial role here. SN - 1743-9159 UR - https://www.unboundmedicine.com/medline/citation/23164988/Influence_of_uracil_on_bacterial_translocation_in_an_intestinal_obstruction_model_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-9191(12)00819-9 DB - PRIME DP - Unbound Medicine ER -