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Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise.
PLoS Negl Trop Dis. 2012; 6(11):e1921.PN

Abstract

BACKGROUND

Drug resistance of Salmonella enterica serovar Typhi (Salmonella Typhi) to first-line antibiotics is emerging in Central Africa. Although increased use of fluoroquinolones is associated with spread of resistance, Salmonella Typhi with decreased ciprofloxacin susceptibility (DCS) has rarely been reported in Central Africa.

METHODOLOGY/PRINCIPAL FINDINGS

As part of a microbiological surveillance study in the Democratic Republic of the Congo (DR Congo), Salmonella Typhi isolates from bloodstream infections were collected prospectively between 2007 and 2011. The genetic relationship of the Salmonella Typhi isolates was assessed by pulsed-field gel electrophoresis (PFGE). The antimicrobial resistance profile of the isolates was determined and mutations associated with DCS were studied. In total, 201 Salmonella Typhi isolates were collected. More than half of the Salmonella Typhi isolates originated from children and young adults aged 5-19. Thirty different PFGE profiles were identified, with 72% of the isolates showing a single profile. Multidrug resistance, DCS and azithromycin resistance were 30.3%, 15.4% and 1.0%, respectively. DCS was associated with point mutations in the gyrA gene at codons 83 and 87.

CONCLUSIONS/SIGNIFICANCE

Our study describes the first report of widespread multidrug resistance and DCS among Salmonella Typhi isolates from DR Congo. Our findings highlight the need for increased microbiological diagnosis and surveillance in DR Congo, being a prerequisite for rational use of antimicrobials and the development of standard treatment guidelines.

Authors+Show Affiliations

National Institute for Biomedical Research, Kinshasa, Democratic Republic of the Congo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23166855

Citation

Lunguya, Octavie, et al. "Salmonella Typhi in the Democratic Republic of the Congo: Fluoroquinolone Decreased Susceptibility On the Rise." PLoS Neglected Tropical Diseases, vol. 6, no. 11, 2012, pp. e1921.
Lunguya O, Lejon V, Phoba MF, et al. Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise. PLoS Negl Trop Dis. 2012;6(11):e1921.
Lunguya, O., Lejon, V., Phoba, M. F., Bertrand, S., Vanhoof, R., Verhaegen, J., Smith, A. M., Keddy, K. H., Muyembe-Tamfum, J. J., & Jacobs, J. (2012). Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise. PLoS Neglected Tropical Diseases, 6(11), e1921. https://doi.org/10.1371/journal.pntd.0001921
Lunguya O, et al. Salmonella Typhi in the Democratic Republic of the Congo: Fluoroquinolone Decreased Susceptibility On the Rise. PLoS Negl Trop Dis. 2012;6(11):e1921. PubMed PMID: 23166855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise. AU - Lunguya,Octavie, AU - Lejon,Veerle, AU - Phoba,Marie-France, AU - Bertrand,Sophie, AU - Vanhoof,Raymond, AU - Verhaegen,Jan, AU - Smith,Anthony Marius, AU - Keddy,Karen Helena, AU - Muyembe-Tamfum,Jean-Jacques, AU - Jacobs,Jan, Y1 - 2012/11/15/ PY - 2012/06/20/received PY - 2012/10/10/accepted PY - 2012/11/21/entrez PY - 2012/11/21/pubmed PY - 2013/4/6/medline SP - e1921 EP - e1921 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 6 IS - 11 N2 - BACKGROUND: Drug resistance of Salmonella enterica serovar Typhi (Salmonella Typhi) to first-line antibiotics is emerging in Central Africa. Although increased use of fluoroquinolones is associated with spread of resistance, Salmonella Typhi with decreased ciprofloxacin susceptibility (DCS) has rarely been reported in Central Africa. METHODOLOGY/PRINCIPAL FINDINGS: As part of a microbiological surveillance study in the Democratic Republic of the Congo (DR Congo), Salmonella Typhi isolates from bloodstream infections were collected prospectively between 2007 and 2011. The genetic relationship of the Salmonella Typhi isolates was assessed by pulsed-field gel electrophoresis (PFGE). The antimicrobial resistance profile of the isolates was determined and mutations associated with DCS were studied. In total, 201 Salmonella Typhi isolates were collected. More than half of the Salmonella Typhi isolates originated from children and young adults aged 5-19. Thirty different PFGE profiles were identified, with 72% of the isolates showing a single profile. Multidrug resistance, DCS and azithromycin resistance were 30.3%, 15.4% and 1.0%, respectively. DCS was associated with point mutations in the gyrA gene at codons 83 and 87. CONCLUSIONS/SIGNIFICANCE: Our study describes the first report of widespread multidrug resistance and DCS among Salmonella Typhi isolates from DR Congo. Our findings highlight the need for increased microbiological diagnosis and surveillance in DR Congo, being a prerequisite for rational use of antimicrobials and the development of standard treatment guidelines. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/23166855/Salmonella_typhi_in_the_democratic_republic_of_the_congo:_fluoroquinolone_decreased_susceptibility_on_the_rise_ L2 - https://dx.plos.org/10.1371/journal.pntd.0001921 DB - PRIME DP - Unbound Medicine ER -