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Systolic and diastolic ventricular function assessed by tissue Doppler imaging in children with chronic kidney disease.
Echocardiography. 2013 Mar; 30(3):331-7.E

Abstract

Chronic kidney disease (CKD) is associated with elevated cardiovascular risk even during childhood. Tissue Doppler is a sensitive technique for the assessment of ventricular dysfunction with relatively little data available in children with CKD. We report a prospective cross-sectional echocardiographic study at a tertiary center. Forty-nine patients with median (range) age 11.2 years (6.9-17.9), weight 39.6 kg (23.6-99.7) and height 146 cm (122-185). Thirty-one patients were male. Median duration of follow-up for CKD was 7.1 years (range 0.13-16.9). Patients were in CKD stage 3 (n = 37) or 4 (n = 12). Mitral valve E-wave, A-wave, and E/A ratio showed mean (SD) z-scores of 0.08 (0.93), 0.12 (0.82) and -0.13 (0.84), respectively. Tissue Doppler imaging (TDI) at the lateral mitral valve annulus showed e', a', s', and E/e' z-scores mean (SD) -1.10 (0.76), -0.29 (0.92), -1.2 (0.7), and 0.86 (1.1), respectively. There was a significant negative correlation of e' and s' z-score with patient age. E/e' ratio correlated positively with patient age. Blood pressure, left ventricular mass, and relative wall thickness did not correlate with tissue Doppler measurements. The e' and s' velocities correlated significantly with each other, suggesting an interaction of systolic and diastolic dysfunction. Children with CKD may have abnormalities of systolic and diastolic ventricular function on TDI, which are not evident on blood pool Doppler. The tissue Doppler results are consistent with worsening ventricular function in older patients.

Authors+Show Affiliations

Department of Congenital Heart Disease, Evelina Children's Hospital, Guys & St Thomas' NHS Foundation Trust, London, UK. john.simpson@gstt.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23167909

Citation

Simpson, John M., et al. "Systolic and Diastolic Ventricular Function Assessed By Tissue Doppler Imaging in Children With Chronic Kidney Disease." Echocardiography (Mount Kisco, N.Y.), vol. 30, no. 3, 2013, pp. 331-7.
Simpson JM, Rawlins D, Mathur S, et al. Systolic and diastolic ventricular function assessed by tissue Doppler imaging in children with chronic kidney disease. Echocardiography. 2013;30(3):331-7.
Simpson, J. M., Rawlins, D., Mathur, S., Chubb, H., & Sinha, M. D. (2013). Systolic and diastolic ventricular function assessed by tissue Doppler imaging in children with chronic kidney disease. Echocardiography (Mount Kisco, N.Y.), 30(3), 331-7. https://doi.org/10.1111/echo.12015
Simpson JM, et al. Systolic and Diastolic Ventricular Function Assessed By Tissue Doppler Imaging in Children With Chronic Kidney Disease. Echocardiography. 2013;30(3):331-7. PubMed PMID: 23167909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systolic and diastolic ventricular function assessed by tissue Doppler imaging in children with chronic kidney disease. AU - Simpson,John M, AU - Rawlins,Debbie, AU - Mathur,Sujeev, AU - Chubb,Henry, AU - Sinha,Manish D, Y1 - 2012/11/20/ PY - 2012/11/22/entrez PY - 2012/11/22/pubmed PY - 2013/8/27/medline SP - 331 EP - 7 JF - Echocardiography (Mount Kisco, N.Y.) JO - Echocardiography VL - 30 IS - 3 N2 - Chronic kidney disease (CKD) is associated with elevated cardiovascular risk even during childhood. Tissue Doppler is a sensitive technique for the assessment of ventricular dysfunction with relatively little data available in children with CKD. We report a prospective cross-sectional echocardiographic study at a tertiary center. Forty-nine patients with median (range) age 11.2 years (6.9-17.9), weight 39.6 kg (23.6-99.7) and height 146 cm (122-185). Thirty-one patients were male. Median duration of follow-up for CKD was 7.1 years (range 0.13-16.9). Patients were in CKD stage 3 (n = 37) or 4 (n = 12). Mitral valve E-wave, A-wave, and E/A ratio showed mean (SD) z-scores of 0.08 (0.93), 0.12 (0.82) and -0.13 (0.84), respectively. Tissue Doppler imaging (TDI) at the lateral mitral valve annulus showed e', a', s', and E/e' z-scores mean (SD) -1.10 (0.76), -0.29 (0.92), -1.2 (0.7), and 0.86 (1.1), respectively. There was a significant negative correlation of e' and s' z-score with patient age. E/e' ratio correlated positively with patient age. Blood pressure, left ventricular mass, and relative wall thickness did not correlate with tissue Doppler measurements. The e' and s' velocities correlated significantly with each other, suggesting an interaction of systolic and diastolic dysfunction. Children with CKD may have abnormalities of systolic and diastolic ventricular function on TDI, which are not evident on blood pool Doppler. The tissue Doppler results are consistent with worsening ventricular function in older patients. SN - 1540-8175 UR - https://www.unboundmedicine.com/medline/citation/23167909/Systolic_and_diastolic_ventricular_function_assessed_by_tissue_Doppler_imaging_in_children_with_chronic_kidney_disease_ L2 - https://doi.org/10.1111/echo.12015 DB - PRIME DP - Unbound Medicine ER -