Citation
Wang, Nuancheng, et al. "Investigation and Comparison of the Mechanistic Steps in the [(Cp*MCl2)2] (Cp* = C5Me5; M = Rh, Ir)-catalyzed Oxidative Annulation of Isoquinolones With Alkynes." Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 19, no. 1, 2013, pp. 358-64.
Wang N, Li B, Song H, et al. Investigation and comparison of the mechanistic steps in the [(Cp*MCl2)2] (Cp* = C5Me5; M = Rh, Ir)-catalyzed oxidative annulation of isoquinolones with alkynes. Chemistry. 2013;19(1):358-64.
Wang, N., Li, B., Song, H., Xu, S., & Wang, B. (2013). Investigation and comparison of the mechanistic steps in the [(Cp*MCl2)2] (Cp* = C5Me5; M = Rh, Ir)-catalyzed oxidative annulation of isoquinolones with alkynes. Chemistry (Weinheim an Der Bergstrasse, Germany), 19(1), 358-64. https://doi.org/10.1002/chem.201203374
Wang N, et al. Investigation and Comparison of the Mechanistic Steps in the [(Cp*MCl2)2] (Cp* = C5Me5; M = Rh, Ir)-catalyzed Oxidative Annulation of Isoquinolones With Alkynes. Chemistry. 2013 Jan 2;19(1):358-64. PubMed PMID: 23168678.
TY - JOUR
T1 - Investigation and comparison of the mechanistic steps in the [(Cp*MCl2)2] (Cp* = C5Me5; M = Rh, Ir)-catalyzed oxidative annulation of isoquinolones with alkynes.
AU - Wang,Nuancheng,
AU - Li,Bin,
AU - Song,Haibin,
AU - Xu,Shansheng,
AU - Wang,Baiquan,
Y1 - 2012/11/21/
PY - 2012/09/20/received
PY - 2012/11/22/entrez
PY - 2012/11/22/pubmed
PY - 2012/11/22/medline
SP - 358
EP - 64
JF - Chemistry (Weinheim an der Bergstrasse, Germany)
JO - Chemistry
VL - 19
IS - 1
N2 - The mechanism of the [(Cp*MCl(2))(2)] (M = Rh, Ir)-catalyzed oxidative annulation reaction of isoquinolones with alkynes was investigated in detail. In the first acetate-assisted C-H-activation process (cyclometalated step) and the subsequent mono-alkyne insertion into the M-C bonds of the cyclometalated compounds, both Rh and Ir complexes participated well. However, the desired final products, dibenzo[a,g]quinolizin-8-one derivatives, were only formed in high yield when the Rh species participated in the final oxidative coupling of the C-N bond. Moreover, a Rh(I) sandwich intermediate was isolated during this transformation. The iridium complexes were found to be inactive in the oxidative coupling processes. All of the relevant intermediates were fully characterized and determined by single-crystal X-ray diffraction analysis. Based on this mechanistic study, a Rh(III)→Rh(I)→Rh(III) catalytic cycle was proposed for this reaction.
SN - 1521-3765
UR - https://www.unboundmedicine.com/medline/citation/23168678/Investigation_and_comparison_of_the_mechanistic_steps_in_the_[_Cp_MCl2_2]__Cp__=_C5Me5
L2 - https://doi.org/10.1002/chem.201203374
DB - PRIME
DP - Unbound Medicine
ER -
