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[Proposed alternative to standard apomorphine challenge test].
Rev Neurol. 2012; 55 Suppl 1:S11-3.RN

Abstract

Subcutaneous apomorphine injection is used as a rescue treatment in the off periods in moderate and advanced Parkinson's disease and also when required to assess the dopaminergic response. It is not recommended as a diagnostic tool in Parkinson's disease because it has more side effects and is less specific than chronic response to levodopa. To calculate the dosage, an apomorphine challenge test is performed, generally taking quite time and testing several doses. We propose an alternative apomorphine challenge test, with a single injection and a higher initial dosage of 2-4 mg, as well as to schedule treatment according to the obtained response at that dosage. This procedure saves time and also allows a better planning of medical attention.

Authors+Show Affiliations

Hospital Universitario Ramon y Cajal, 28034 Madrid, Espana.No affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

spa

PubMed ID

23169227

Citation

Martínez-Castrillo, Juan Carlos, and Juan Andrés Burguera. "[Proposed Alternative to Standard Apomorphine Challenge Test]." Revista De Neurologia, vol. 55 Suppl 1, 2012, pp. S11-3.
Martínez-Castrillo JC, Burguera JA. [Proposed alternative to standard apomorphine challenge test]. Rev Neurol. 2012;55 Suppl 1:S11-3.
Martínez-Castrillo, J. C., & Burguera, J. A. (2012). [Proposed alternative to standard apomorphine challenge test]. Revista De Neurologia, 55 Suppl 1, S11-3.
Martínez-Castrillo JC, Burguera JA. [Proposed Alternative to Standard Apomorphine Challenge Test]. Rev Neurol. 2012;55 Suppl 1:S11-3. PubMed PMID: 23169227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Proposed alternative to standard apomorphine challenge test]. AU - Martínez-Castrillo,Juan Carlos, AU - Burguera,Juan Andrés, PY - 2012/11/22/entrez PY - 2012/10/20/pubmed PY - 2014/8/19/medline SP - S11 EP - 3 JF - Revista de neurologia JO - Rev Neurol VL - 55 Suppl 1 N2 - Subcutaneous apomorphine injection is used as a rescue treatment in the off periods in moderate and advanced Parkinson's disease and also when required to assess the dopaminergic response. It is not recommended as a diagnostic tool in Parkinson's disease because it has more side effects and is less specific than chronic response to levodopa. To calculate the dosage, an apomorphine challenge test is performed, generally taking quite time and testing several doses. We propose an alternative apomorphine challenge test, with a single injection and a higher initial dosage of 2-4 mg, as well as to schedule treatment according to the obtained response at that dosage. This procedure saves time and also allows a better planning of medical attention. SN - 1576-6578 UR - https://www.unboundmedicine.com/medline/citation/23169227/[Proposed_alternative_to_standard_apomorphine_challenge_test]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -