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The vagus nerve and the inflammatory reflex--linking immunity and metabolism.
Nat Rev Endocrinol. 2012 Dec; 8(12):743-54.NR

Abstract

The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.

Authors+Show Affiliations

Center for Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA. vpavlov@nshs.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

23169440

Citation

Pavlov, Valentin A., and Kevin J. Tracey. "The Vagus Nerve and the Inflammatory Reflex--linking Immunity and Metabolism." Nature Reviews. Endocrinology, vol. 8, no. 12, 2012, pp. 743-54.
Pavlov VA, Tracey KJ. The vagus nerve and the inflammatory reflex--linking immunity and metabolism. Nat Rev Endocrinol. 2012;8(12):743-54.
Pavlov, V. A., & Tracey, K. J. (2012). The vagus nerve and the inflammatory reflex--linking immunity and metabolism. Nature Reviews. Endocrinology, 8(12), 743-54. https://doi.org/10.1038/nrendo.2012.189
Pavlov VA, Tracey KJ. The Vagus Nerve and the Inflammatory Reflex--linking Immunity and Metabolism. Nat Rev Endocrinol. 2012;8(12):743-54. PubMed PMID: 23169440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The vagus nerve and the inflammatory reflex--linking immunity and metabolism. AU - Pavlov,Valentin A, AU - Tracey,Kevin J, PY - 2012/11/22/entrez PY - 2012/11/22/pubmed PY - 2013/8/27/medline SP - 743 EP - 54 JF - Nature reviews. Endocrinology JO - Nat Rev Endocrinol VL - 8 IS - 12 N2 - The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders. SN - 1759-5037 UR - https://www.unboundmedicine.com/medline/citation/23169440/full_citation L2 - https://doi.org/10.1038/nrendo.2012.189 DB - PRIME DP - Unbound Medicine ER -