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Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women.
Nutr J. 2012 Nov 21; 11:98.NJ

Abstract

BACKGROUND

Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown.

OBJECTIVE

This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk.

METHODS

Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period.

RESULTS

Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 ± 1.4 kg) versus the IFCR-F group (2.5 ± 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 ± 1.2 kg and 1.9 ± 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 ± 0.5 kg) and IFCR-F (0.3 ± 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR-F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only.

CONCLUSION

These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 West Taylor Street, Room 506F, Chicago, IL 60612, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23171320

Citation

Klempel, Monica C., et al. "Intermittent Fasting Combined With Calorie Restriction Is Effective for Weight Loss and Cardio-protection in Obese Women." Nutrition Journal, vol. 11, 2012, p. 98.
Klempel MC, Kroeger CM, Bhutani S, et al. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutr J. 2012;11:98.
Klempel, M. C., Kroeger, C. M., Bhutani, S., Trepanowski, J. F., & Varady, K. A. (2012). Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutrition Journal, 11, 98. https://doi.org/10.1186/1475-2891-11-98
Klempel MC, et al. Intermittent Fasting Combined With Calorie Restriction Is Effective for Weight Loss and Cardio-protection in Obese Women. Nutr J. 2012 Nov 21;11:98. PubMed PMID: 23171320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. AU - Klempel,Monica C, AU - Kroeger,Cynthia M, AU - Bhutani,Surabhi, AU - Trepanowski,John F, AU - Varady,Krista A, Y1 - 2012/11/21/ PY - 2012/08/14/received PY - 2012/11/20/accepted PY - 2012/11/23/entrez PY - 2012/11/23/pubmed PY - 2013/4/13/medline SP - 98 EP - 98 JF - Nutrition journal JO - Nutr J VL - 11 N2 - BACKGROUND: Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. OBJECTIVE: This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk. METHODS: Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period. RESULTS: Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 ± 1.4 kg) versus the IFCR-F group (2.5 ± 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 ± 1.2 kg and 1.9 ± 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 ± 0.5 kg) and IFCR-F (0.3 ± 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR-F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only. CONCLUSION: These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/23171320/Intermittent_fasting_combined_with_calorie_restriction_is_effective_for_weight_loss_and_cardio_protection_in_obese_women_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-11-98 DB - PRIME DP - Unbound Medicine ER -