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Similar response rates in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis after 1 year of treatment with etanercept: results from the ESTHER trial.
Ann Rheum Dis 2013; 72(6):823-5AR

Abstract

OBJECTIVE

We assessed whether there is a difference to etanercept (ETA) treatment in patients with ankylosing spondylitis (AS) compared with non-radiographic axial SpA (nr-axSpA) patients with a disease duration <5 years.

METHOD

AS (n=20) and nr-axSpA (n=20) patients who were treated with ETA for 1 year were compared for differences in baseline data and treatment effect. Clinical, laboratory and MRI of sacroiliac joints (SI-joints) and spine were analysed.

RESULTS

At baseline, there were no significant differences between the 20 AS and the 20 nr-axSpA patients regarding age, disease duration, gender, HLA-B27 and clinical disease activity in terms of Bath AS Disease Activity Index (BASDAI), C-reactive protein and MRI SI-joint and spine scores in the AS compared with the nr-axSpA group. After 1 year of treatment with ETA the treatment effect was similarly good in AS and nr-axSpA (reduction of BASDAI by 3.3 (95% CI 2.2 to 3.8) vs 3.6 (95% CI 2.8 to 4.4) and reduction of AS Disease Activity Score by 1.8 (95% CI 1.5 to 2.2) vs 1.8 (95% CI 1.5 to 2.1), respectively.

CONCLUSIONS

The response rate to TNF-blockers does not differ between AS and nr-axSpA if the baseline data regarding symptom duration and disease activity are similar for the two groups.

Authors+Show Affiliations

Department of Rheumatology, Charité Medical University, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23172749

Citation

Song, In-Ho, et al. "Similar Response Rates in Patients With Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis After 1 Year of Treatment With Etanercept: Results From the ESTHER Trial." Annals of the Rheumatic Diseases, vol. 72, no. 6, 2013, pp. 823-5.
Song IH, Weiβ A, Hermann KG, et al. Similar response rates in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis after 1 year of treatment with etanercept: results from the ESTHER trial. Ann Rheum Dis. 2013;72(6):823-5.
Song, I. H., Weiβ, A., Hermann, K. G., Haibel, H., Althoff, C. E., Poddubnyy, D., ... Sieper, J. (2013). Similar response rates in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis after 1 year of treatment with etanercept: results from the ESTHER trial. Annals of the Rheumatic Diseases, 72(6), pp. 823-5. doi:10.1136/annrheumdis-2012-202389.
Song IH, et al. Similar Response Rates in Patients With Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis After 1 Year of Treatment With Etanercept: Results From the ESTHER Trial. Ann Rheum Dis. 2013;72(6):823-5. PubMed PMID: 23172749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similar response rates in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis after 1 year of treatment with etanercept: results from the ESTHER trial. AU - Song,In-Ho, AU - Weiβ,Anja, AU - Hermann,Kay-Geert A, AU - Haibel,Hildrun, AU - Althoff,Christian E, AU - Poddubnyy,Denis, AU - Listing,Joachim, AU - Lange,Ekkehard, AU - Freundlich,Bruce, AU - Rudwaleit,Martin, AU - Sieper,Joachim, Y1 - 2012/11/21/ PY - 2012/11/23/entrez PY - 2012/11/23/pubmed PY - 2013/7/16/medline KW - Ankylosing Spondylitis KW - Anti-TNF KW - Magnetic Resonance Imaging KW - Spondyloarthritis SP - 823 EP - 5 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 72 IS - 6 N2 - OBJECTIVE: We assessed whether there is a difference to etanercept (ETA) treatment in patients with ankylosing spondylitis (AS) compared with non-radiographic axial SpA (nr-axSpA) patients with a disease duration <5 years. METHOD: AS (n=20) and nr-axSpA (n=20) patients who were treated with ETA for 1 year were compared for differences in baseline data and treatment effect. Clinical, laboratory and MRI of sacroiliac joints (SI-joints) and spine were analysed. RESULTS: At baseline, there were no significant differences between the 20 AS and the 20 nr-axSpA patients regarding age, disease duration, gender, HLA-B27 and clinical disease activity in terms of Bath AS Disease Activity Index (BASDAI), C-reactive protein and MRI SI-joint and spine scores in the AS compared with the nr-axSpA group. After 1 year of treatment with ETA the treatment effect was similarly good in AS and nr-axSpA (reduction of BASDAI by 3.3 (95% CI 2.2 to 3.8) vs 3.6 (95% CI 2.8 to 4.4) and reduction of AS Disease Activity Score by 1.8 (95% CI 1.5 to 2.2) vs 1.8 (95% CI 1.5 to 2.1), respectively. CONCLUSIONS: The response rate to TNF-blockers does not differ between AS and nr-axSpA if the baseline data regarding symptom duration and disease activity are similar for the two groups. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/23172749/Similar_response_rates_in_patients_with_ankylosing_spondylitis_and_non_radiographic_axial_spondyloarthritis_after_1_year_of_treatment_with_etanercept:_results_from_the_ESTHER_trial_ L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&amp;pmid=23172749 DB - PRIME DP - Unbound Medicine ER -