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Role of propolis (bee glue) in improving histopathological changes of the kidney of rat treated with aluminum chloride.

Abstract

Humans are frequently exposed to aluminum from various food additives, therapeutic treatments and the environment, and it can be potentially toxic. This study is aimed to elucidate the protective effects of propolis against aluminum chloride (AlCl3 )-induced histopathological and immunohistochemical changes in kidney tissues of rats. Sixty Wistar Albino male rats (average weight 250-300 g) were divided into three equal groups. The first served as a negative control. The second received AlCl₃ (34 mg/kg bw, 1/ 25 LD 50). The third were administered AlCl₃ (34 mg/kg bw, 1/ 25 LD 50) plus propolis (50 mg/kg bw). Doses were given once daily via a gavage for 8 weeks every day. The results showed that shrunken glomeruli, intraglomerular congestion, loss of apical microvilli, degeneration of mitochondria and widened rough endoplasmic reticulum were also observed in the Proximal Convoluted Tubules of these animals. Treatment with propolis ameliorated the harmful effects of AlCl₃ ; this was also proved histopathologically by the noticeable improvement in the renal tissues. There were also significant variations in the expressed of ki-67 and p53 proteins. It can be concluded that propolis may be promising as a natural therapeutic agent in AlCl₃ -induced renal toxicity and oxidative stress in rat kidneys.

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  • Authors+Show Affiliations

    ,

    Department of Molecular Biology, Genetic Engineering and Biotechnology Research Inst., Minufiya University, Egypt; Department of pathology, College of medicine, Taif University, Kingdom of Saudi Arabia.

    ,

    Source

    Environmental toxicology 29:9 2014 Sep pg 1000-10

    MeSH

    Aluminum Compounds
    Animals
    Chlorides
    Dose-Response Relationship, Drug
    Humans
    Kidney
    Male
    Microscopy, Electron, Transmission
    Oxidative Stress
    Propolis
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23172825