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[Metastatic lymph node ratio and outcome of surgical patients with stage III colorectal cancer].
Nan Fang Yi Ke Da Xue Xue Bao. 2012 Nov; 32(11):1663-6.NF

Abstract

OBJECTIVE

Evaluate the prognostic value of lymph node ratio (LNR) in patients undergoing resection of stage III colorectal cancer.

METHODS

The clinicopathological and follow-up data were collected from 174 surgical patients with stage III colorectal cancer. The 5-year disease-free survival (DFS) and overall survival (OS) were evaluated using Kaplan-Meier method. The impact of LNR and clinicopathological factors on DFS and OS were evaluated using univariate and multivariate analysis.

RESULTS

After a median follow-up of 62.5 months, the 5-year DFS and OS of the patients were 51.8% and 56.3%, respectively. The median number of lymph nodes harvested and the median number of positive lymph nodes examined were 10 and 3, respectively. The patients were stratified into 4 groups according to LNR quartiles (LNR1, LNR≤0.125; LNR2, 0.125<LNR≤0.260; LNR3, 0.260<LNR≤0.500; LNR4, LNR>0.500), whose 5-year DFS and OS were 64.2%, 53.5%, 41.8%, and 25.7% (P<0.05) and 68.1%, 60.8%, 49.2%, and 32.7% (P<0.05), respectively. Multivariate analysis identified age, T stage and LNR as the independent predictors of both DFS and OS. Subgroup analysis showed that LNR had an independent prognostic value on DFS and OS irrespective of the number of lymph nodes harvested.

CONCLUSION

LNR is an independent prognostic factor for survival in patients with stage III colorectal cancer and is superior to the pN category in TNM staging.

Authors+Show Affiliations

Department of Gastrointestinal Surgery, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. 5x959liang@163.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

chi

PubMed ID

23174600

Citation

Liang, Jianzhong, et al. "[Metastatic Lymph Node Ratio and Outcome of Surgical Patients With Stage III Colorectal Cancer]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 32, no. 11, 2012, pp. 1663-6.
Liang J, Wei Y, Zhao C, et al. [Metastatic lymph node ratio and outcome of surgical patients with stage III colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32(11):1663-6.
Liang, J., Wei, Y., Zhao, C., & Hong, C. (2012). [Metastatic lymph node ratio and outcome of surgical patients with stage III colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 32(11), 1663-6.
Liang J, et al. [Metastatic Lymph Node Ratio and Outcome of Surgical Patients With Stage III Colorectal Cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32(11):1663-6. PubMed PMID: 23174600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Metastatic lymph node ratio and outcome of surgical patients with stage III colorectal cancer]. AU - Liang,Jianzhong, AU - Wei,Yisheng, AU - Zhao,Chuxiong, AU - Hong,Chuyuan, PY - 2012/11/24/entrez PY - 2012/11/24/pubmed PY - 2013/8/30/medline SP - 1663 EP - 6 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 32 IS - 11 N2 - OBJECTIVE: Evaluate the prognostic value of lymph node ratio (LNR) in patients undergoing resection of stage III colorectal cancer. METHODS: The clinicopathological and follow-up data were collected from 174 surgical patients with stage III colorectal cancer. The 5-year disease-free survival (DFS) and overall survival (OS) were evaluated using Kaplan-Meier method. The impact of LNR and clinicopathological factors on DFS and OS were evaluated using univariate and multivariate analysis. RESULTS: After a median follow-up of 62.5 months, the 5-year DFS and OS of the patients were 51.8% and 56.3%, respectively. The median number of lymph nodes harvested and the median number of positive lymph nodes examined were 10 and 3, respectively. The patients were stratified into 4 groups according to LNR quartiles (LNR1, LNR≤0.125; LNR2, 0.125<LNR≤0.260; LNR3, 0.260<LNR≤0.500; LNR4, LNR>0.500), whose 5-year DFS and OS were 64.2%, 53.5%, 41.8%, and 25.7% (P<0.05) and 68.1%, 60.8%, 49.2%, and 32.7% (P<0.05), respectively. Multivariate analysis identified age, T stage and LNR as the independent predictors of both DFS and OS. Subgroup analysis showed that LNR had an independent prognostic value on DFS and OS irrespective of the number of lymph nodes harvested. CONCLUSION: LNR is an independent prognostic factor for survival in patients with stage III colorectal cancer and is superior to the pN category in TNM staging. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/23174600/[Metastatic_lymph_node_ratio_and_outcome_of_surgical_patients_with_stage_III_colorectal_cancer]_ L2 - http://www.diseaseinfosearch.org/result/9749 DB - PRIME DP - Unbound Medicine ER -