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Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences.
J Psychiatr Res. 2013 Mar; 47(3):315-22.JP

Abstract

Trans-resveratrol is a phenolic compound enriched in polygonum cuspidatum and has diverse biological activities. There is only limited information about the antidepressant-like effect of trans-resveratrol. The present study investigated whether trans-resveratrol has antidepressant-like activity in rats exposed to chronic stress by using two behavioral tasks, shuttle box and sucrose preference tests. The monoamines (5-HT, noradrenaline and dopamine) and their metabolites as well as monoamine oxidase (MAO) enzyme activities in different brain regions were also measured. Compared to unstressed rats, those exposed to chronic stress paradigm showed performance deficits in the shuttle box, reduced sucrose preference, less weight gain and the increase in the ratio of adrenal gland to body weight, which were reversed by chronic treatment with trans-resveratrol (40 and 80 mg/kg, i.g.). The neurochemical assay showed that higher dose of trans-resveratrol (80 mg/kg) produced a marked increase of 5-HT levels in three brain regions, the frontal cortex, hippocampus and hypothalamus. Noradrenaline and dopamine levels were also increased both in the frontal cortex and striatum. Furthermore, chronic treatment with trans-resveratrol was found to inhibit monoamine oxidase-A (MAO-A) activity in all the four brain regions, particularly in the frontal cortex and hippocampus; while MAO-B activity was not affected. These findings indicate that the antidepressant-like effect of trans-resveratrol involves the regulation of the central serotonin and noradrenaline levels and the related MAO-A activities.

Authors+Show Affiliations

Wenzhou Third People's Hospital, Wenzhou, Zhejiang Province 325000, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23174668

Citation

Yu, Yingcong, et al. "Antidepressant-like Effect of Trans-resveratrol in Chronic Stress Model: Behavioral and Neurochemical Evidences." Journal of Psychiatric Research, vol. 47, no. 3, 2013, pp. 315-22.
Yu Y, Wang R, Chen C, et al. Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences. J Psychiatr Res. 2013;47(3):315-22.
Yu, Y., Wang, R., Chen, C., Du, X., Ruan, L., Sun, J., Li, J., Zhang, L., O'Donnell, J. M., Pan, J., & Xu, Y. (2013). Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences. Journal of Psychiatric Research, 47(3), 315-22. https://doi.org/10.1016/j.jpsychires.2012.10.018
Yu Y, et al. Antidepressant-like Effect of Trans-resveratrol in Chronic Stress Model: Behavioral and Neurochemical Evidences. J Psychiatr Res. 2013;47(3):315-22. PubMed PMID: 23174668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences. AU - Yu,Yingcong, AU - Wang,Rui, AU - Chen,Chunbai, AU - Du,Xia, AU - Ruan,Lina, AU - Sun,Jiao, AU - Li,Jianxin, AU - Zhang,Lu, AU - O'Donnell,James M, AU - Pan,Jianchun, AU - Xu,Ying, Y1 - 2012/11/19/ PY - 2012/10/09/received PY - 2012/10/26/revised PY - 2012/10/30/accepted PY - 2012/11/24/entrez PY - 2012/11/24/pubmed PY - 2014/5/31/medline SP - 315 EP - 22 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 47 IS - 3 N2 - Trans-resveratrol is a phenolic compound enriched in polygonum cuspidatum and has diverse biological activities. There is only limited information about the antidepressant-like effect of trans-resveratrol. The present study investigated whether trans-resveratrol has antidepressant-like activity in rats exposed to chronic stress by using two behavioral tasks, shuttle box and sucrose preference tests. The monoamines (5-HT, noradrenaline and dopamine) and their metabolites as well as monoamine oxidase (MAO) enzyme activities in different brain regions were also measured. Compared to unstressed rats, those exposed to chronic stress paradigm showed performance deficits in the shuttle box, reduced sucrose preference, less weight gain and the increase in the ratio of adrenal gland to body weight, which were reversed by chronic treatment with trans-resveratrol (40 and 80 mg/kg, i.g.). The neurochemical assay showed that higher dose of trans-resveratrol (80 mg/kg) produced a marked increase of 5-HT levels in three brain regions, the frontal cortex, hippocampus and hypothalamus. Noradrenaline and dopamine levels were also increased both in the frontal cortex and striatum. Furthermore, chronic treatment with trans-resveratrol was found to inhibit monoamine oxidase-A (MAO-A) activity in all the four brain regions, particularly in the frontal cortex and hippocampus; while MAO-B activity was not affected. These findings indicate that the antidepressant-like effect of trans-resveratrol involves the regulation of the central serotonin and noradrenaline levels and the related MAO-A activities. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/23174668/Antidepressant_like_effect_of_trans_resveratrol_in_chronic_stress_model:_behavioral_and_neurochemical_evidences_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(12)00339-1 DB - PRIME DP - Unbound Medicine ER -