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Relationship between childhood body mass index and young adult asthma.
Ann Allergy Asthma Immunol 2012; 109(6):408-411.e1AA

Abstract

BACKGROUND

The relationship between obesity and asthma is an area of debate.

OBJECTIVE

To investigate the association of elevated body mass index (BMI) at a young age and young adult asthma.

METHODS

BMI, questionnaires, and serologic tests results were analyzed in participants of a predominantly white, middle-class, population-based birth cohort from Detroit, Michigan at 6 to 8 and 18 years of age. Asthma diagnosis was based on medical record data. Allergen specific IgE was analyzed using UniCAP, with atopy defined as 1 or more allergen specific IgE levels of 0.35 kU/L or higher. Overweight was defined as a BMI in 85th percentile or higher.

RESULTS

A total of 10.6% of overweight males at 6 to 8 years of age had current asthma at 18 to 20 years of age compared with 3.2% of males who were normal or underweight (relative risk [RR], 3.3; 95% confidence interval [CI], 1.0-11.0; P=.048). A total of 19.6% of females who were overweight at 6 to 8 years of age had asthma compared with 10.3% of females who were normal or underweight (RR, 1.9; 95% CI, 0.9-3.9; P=.09). After adjustment for atopy at 6 to 8 years of age, overweight males had an adjusted RR of 4.7 (95% CI, 1.4-16.2; P=.01), and overweight females had an adjusted RR of 1.7 (95% CI, 0.8-3.3; P=.15). Change in BMI between 6 to 8 years of age and 18 to 20 years of age was also examined. Patients with persistently elevated BMI exhibited increased risk of asthma as young adults (RR, 2.4; 95% CI, 1.2-4.7) but not with an increasing BMI (RR, 0.8; 95% CI, 0.3-2.2) or a decreasing BMI (RR, 0.8; 95% CI, 0.3-2.2).

CONCLUSION

Overweight males 6 to 8 years of age have increased risk of asthma as young adults. Being overweight remains a predictor of asthma after adjustment for early atopy. A similar but not statistically significant trend was also seen among overweight females. Overweight body habitus throughout childhood is a risk factor for young adult asthma.

Authors+Show Affiliations

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA. minto.porter@essentiahealth.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23176878

Citation

Porter, Minto, et al. "Relationship Between Childhood Body Mass Index and Young Adult Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 109, no. 6, 2012, pp. 408-411.e1.
Porter M, Wegienka G, Havstad S, et al. Relationship between childhood body mass index and young adult asthma. Ann Allergy Asthma Immunol. 2012;109(6):408-411.e1.
Porter, M., Wegienka, G., Havstad, S., Nageotte, C. G., Johnson, C. C., Ownby, D. R., & Zoratti, E. M. (2012). Relationship between childhood body mass index and young adult asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 109(6), pp. 408-411.e1. doi:10.1016/j.anai.2012.09.009.
Porter M, et al. Relationship Between Childhood Body Mass Index and Young Adult Asthma. Ann Allergy Asthma Immunol. 2012;109(6):408-411.e1. PubMed PMID: 23176878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between childhood body mass index and young adult asthma. AU - Porter,Minto, AU - Wegienka,Ganesa, AU - Havstad,Suzanne, AU - Nageotte,Christian G, AU - Johnson,Christine Cole, AU - Ownby,Dennis R, AU - Zoratti,Edward M, PY - 2012/06/13/received PY - 2012/09/07/revised PY - 2012/09/11/accepted PY - 2012/11/27/entrez PY - 2012/11/28/pubmed PY - 2013/4/25/medline SP - 408 EP - 411.e1 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 109 IS - 6 N2 - BACKGROUND: The relationship between obesity and asthma is an area of debate. OBJECTIVE: To investigate the association of elevated body mass index (BMI) at a young age and young adult asthma. METHODS: BMI, questionnaires, and serologic tests results were analyzed in participants of a predominantly white, middle-class, population-based birth cohort from Detroit, Michigan at 6 to 8 and 18 years of age. Asthma diagnosis was based on medical record data. Allergen specific IgE was analyzed using UniCAP, with atopy defined as 1 or more allergen specific IgE levels of 0.35 kU/L or higher. Overweight was defined as a BMI in 85th percentile or higher. RESULTS: A total of 10.6% of overweight males at 6 to 8 years of age had current asthma at 18 to 20 years of age compared with 3.2% of males who were normal or underweight (relative risk [RR], 3.3; 95% confidence interval [CI], 1.0-11.0; P=.048). A total of 19.6% of females who were overweight at 6 to 8 years of age had asthma compared with 10.3% of females who were normal or underweight (RR, 1.9; 95% CI, 0.9-3.9; P=.09). After adjustment for atopy at 6 to 8 years of age, overweight males had an adjusted RR of 4.7 (95% CI, 1.4-16.2; P=.01), and overweight females had an adjusted RR of 1.7 (95% CI, 0.8-3.3; P=.15). Change in BMI between 6 to 8 years of age and 18 to 20 years of age was also examined. Patients with persistently elevated BMI exhibited increased risk of asthma as young adults (RR, 2.4; 95% CI, 1.2-4.7) but not with an increasing BMI (RR, 0.8; 95% CI, 0.3-2.2) or a decreasing BMI (RR, 0.8; 95% CI, 0.3-2.2). CONCLUSION: Overweight males 6 to 8 years of age have increased risk of asthma as young adults. Being overweight remains a predictor of asthma after adjustment for early atopy. A similar but not statistically significant trend was also seen among overweight females. Overweight body habitus throughout childhood is a risk factor for young adult asthma. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/23176878/Relationship_between_childhood_body_mass_index_and_young_adult_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(12)00679-5 DB - PRIME DP - Unbound Medicine ER -