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Dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: results from the randomised, placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS).
Eur Urol 2013; 63(5):779-87EU

Abstract

BACKGROUND

Rising prostate-specific antigen (PSA) levels after radical therapy are indicative of recurrent or residual prostate cancer (PCa). This biochemical recurrence typically predates clinically detectable metastatic disease by several years. Management of patients with biochemical recurrence is controversial.

OBJECTIVE

To assess the effect of dutasteride on progression of PCa in patients with biochemical failure after radical therapy.

DESIGN, SETTING, AND PARTICIPANTS

Randomised, double-blind, placebo-controlled trial in 294 men from 64 centres across 9 European countries.

INTERVENTION

The 5α-reductase inhibitor, dutasteride.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS

The primary end point was time to PSA doubling from start of randomised treatment, analysed by log-rank test stratified by previous therapy and investigative-site cluster. Secondary end points included time to disease progression and the proportion of subjects with disease progression.

RESULTS AND LIMITATIONS

Of the 294 subjects randomised (147 in each treatment group), 187 (64%) completed 24 mo of treatment and 107 discontinued treatment prematurely (71 [48%] of the placebo group, 36 [24%] of the dutasteride group). Dutasteride significantly delayed the time to PSA doubling compared with placebo after 24 mo of treatment (p<0.001); the relative risk (RR) reduction was 66.1% (95% confidence interval [CI], 50.35-76.90) for the overall study period. Dutasteride also significantly delayed disease progression (which included PSA- and non-PSA-related outcomes) compared with placebo (p<0.001); the overall RR reduction in favour of dutasteride was 59% (95% CI, 32.53-75.09). The incidence of adverse events (AEs), serious AEs, and AEs leading to study withdrawal were similar between the treatment groups. A limitation was that investigators were not blinded to PSA levels during the study.

CONCLUSIONS

Dutasteride delayed the biochemical progression of PCa in patients with biochemical failure after radical therapy for clinically localised disease. The safety and tolerability of dutasteride were generally consistent with previous experience.

CLINICAL TRIAL REGISTRY

ClinicalTrials.gov, NCT00558363.

Authors+Show Affiliations

Erasmus Medical Centre, Rotterdam, The Netherlands. secr.schroder@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23176897

Citation

Schröder, Fritz, et al. "Dutasteride Treatment Over 2 Years Delays Prostate-specific Antigen Progression in Patients With Biochemical Failure After Radical Therapy for Prostate Cancer: Results From the Randomised, Placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS)." European Urology, vol. 63, no. 5, 2013, pp. 779-87.
Schröder F, Bangma C, Angulo JC, et al. Dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: results from the randomised, placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS). Eur Urol. 2013;63(5):779-87.
Schröder, F., Bangma, C., Angulo, J. C., Alcaraz, A., Colombel, M., McNicholas, T., ... Castro, R. (2013). Dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: results from the randomised, placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS). European Urology, 63(5), pp. 779-87. doi:10.1016/j.eururo.2012.11.006.
Schröder F, et al. Dutasteride Treatment Over 2 Years Delays Prostate-specific Antigen Progression in Patients With Biochemical Failure After Radical Therapy for Prostate Cancer: Results From the Randomised, Placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS). Eur Urol. 2013;63(5):779-87. PubMed PMID: 23176897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: results from the randomised, placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS). AU - Schröder,Fritz, AU - Bangma,Chris, AU - Angulo,Javier C, AU - Alcaraz,Antonio, AU - Colombel,Marc, AU - McNicholas,Tom, AU - Tammela,Teuvo L, AU - Nandy,Indrani, AU - Castro,Ramiro, Y1 - 2012/11/12/ PY - 2012/09/11/received PY - 2012/11/04/accepted PY - 2012/11/27/entrez PY - 2012/11/28/pubmed PY - 2013/9/26/medline SP - 779 EP - 87 JF - European urology JO - Eur. Urol. VL - 63 IS - 5 N2 - BACKGROUND: Rising prostate-specific antigen (PSA) levels after radical therapy are indicative of recurrent or residual prostate cancer (PCa). This biochemical recurrence typically predates clinically detectable metastatic disease by several years. Management of patients with biochemical recurrence is controversial. OBJECTIVE: To assess the effect of dutasteride on progression of PCa in patients with biochemical failure after radical therapy. DESIGN, SETTING, AND PARTICIPANTS: Randomised, double-blind, placebo-controlled trial in 294 men from 64 centres across 9 European countries. INTERVENTION: The 5α-reductase inhibitor, dutasteride. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary end point was time to PSA doubling from start of randomised treatment, analysed by log-rank test stratified by previous therapy and investigative-site cluster. Secondary end points included time to disease progression and the proportion of subjects with disease progression. RESULTS AND LIMITATIONS: Of the 294 subjects randomised (147 in each treatment group), 187 (64%) completed 24 mo of treatment and 107 discontinued treatment prematurely (71 [48%] of the placebo group, 36 [24%] of the dutasteride group). Dutasteride significantly delayed the time to PSA doubling compared with placebo after 24 mo of treatment (p<0.001); the relative risk (RR) reduction was 66.1% (95% confidence interval [CI], 50.35-76.90) for the overall study period. Dutasteride also significantly delayed disease progression (which included PSA- and non-PSA-related outcomes) compared with placebo (p<0.001); the overall RR reduction in favour of dutasteride was 59% (95% CI, 32.53-75.09). The incidence of adverse events (AEs), serious AEs, and AEs leading to study withdrawal were similar between the treatment groups. A limitation was that investigators were not blinded to PSA levels during the study. CONCLUSIONS: Dutasteride delayed the biochemical progression of PCa in patients with biochemical failure after radical therapy for clinically localised disease. The safety and tolerability of dutasteride were generally consistent with previous experience. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov, NCT00558363. SN - 1873-7560 UR - https://www.unboundmedicine.com/medline/citation/23176897/Dutasteride_treatment_over_2_years_delays_prostate_specific_antigen_progression_in_patients_with_biochemical_failure_after_radical_therapy_for_prostate_cancer:_results_from_the_randomised_placebo_controlled_Avodart_After_Radical_Therapy_for_Prostate_Cancer_Study__ARTS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0302-2838(12)01337-1 DB - PRIME DP - Unbound Medicine ER -