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Development of a recombinant vaccine against infectious coryza in chickens.
Res Vet Sci 2013; 94(3):504-9RV

Abstract

Infectious coryza is an acute respiratory disease of chickens caused by Avibacterium paragallinarum, and this infection is associated with growth retardation and reduced egg production. Previous studies have shown that HMTp210, a 210-kDa outer-membrane protein, is the major protective antigen of Av. paragallinarum both serovars A and C. Region 2 is a serovar-specific domain in the HMTp210 protein. Although the serovar C region 2 has been reported to be an effective vaccine antigen for infectious coryza, there have been no reports on the efficacy of region 2 from serovar A. In the current study, region 2 from serovars A and C was expressed as a fusion peptide. Chickens inoculated with vaccine consisting of 0.6 μg of the fusion peptide showed no clinical signs of disease after challenge with either serovar A or C, and there were no side effects such as swelling at the injection site. These results demonstrate that the recombinant fusion peptide derived from HMTp210 could be useful for producing effective and safe vaccines against infectious coryza in chickens.

Authors+Show Affiliations

The Chemo-Sero-Therapeutic Research Institute, Kikuchi Research Center, 1314-1 Kawabe Kyokushi, Kikuchi-shi, Kumamoto 869-1298, Japan. sakamoto-ryu@kaketsuken.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23178044

Citation

Sakamoto, Ryuichi, et al. "Development of a Recombinant Vaccine Against Infectious Coryza in Chickens." Research in Veterinary Science, vol. 94, no. 3, 2013, pp. 504-9.
Sakamoto R, Baba S, Ushijima T, et al. Development of a recombinant vaccine against infectious coryza in chickens. Res Vet Sci. 2013;94(3):504-9.
Sakamoto, R., Baba, S., Ushijima, T., Kino, Y., Honda, T., Mizokami, H., & Sakaguchi, M. (2013). Development of a recombinant vaccine against infectious coryza in chickens. Research in Veterinary Science, 94(3), pp. 504-9. doi:10.1016/j.rvsc.2012.10.027.
Sakamoto R, et al. Development of a Recombinant Vaccine Against Infectious Coryza in Chickens. Res Vet Sci. 2013;94(3):504-9. PubMed PMID: 23178044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a recombinant vaccine against infectious coryza in chickens. AU - Sakamoto,Ryuichi, AU - Baba,Susumu, AU - Ushijima,Toshihiro, AU - Kino,Yoichiro, AU - Honda,Takashi, AU - Mizokami,Hiroshi, AU - Sakaguchi,Masashi, Y1 - 2012/11/22/ PY - 2012/04/01/received PY - 2012/10/21/revised PY - 2012/10/28/accepted PY - 2012/11/27/entrez PY - 2012/11/28/pubmed PY - 2013/12/16/medline SP - 504 EP - 9 JF - Research in veterinary science JO - Res. Vet. Sci. VL - 94 IS - 3 N2 - Infectious coryza is an acute respiratory disease of chickens caused by Avibacterium paragallinarum, and this infection is associated with growth retardation and reduced egg production. Previous studies have shown that HMTp210, a 210-kDa outer-membrane protein, is the major protective antigen of Av. paragallinarum both serovars A and C. Region 2 is a serovar-specific domain in the HMTp210 protein. Although the serovar C region 2 has been reported to be an effective vaccine antigen for infectious coryza, there have been no reports on the efficacy of region 2 from serovar A. In the current study, region 2 from serovars A and C was expressed as a fusion peptide. Chickens inoculated with vaccine consisting of 0.6 μg of the fusion peptide showed no clinical signs of disease after challenge with either serovar A or C, and there were no side effects such as swelling at the injection site. These results demonstrate that the recombinant fusion peptide derived from HMTp210 could be useful for producing effective and safe vaccines against infectious coryza in chickens. SN - 1532-2661 UR - https://www.unboundmedicine.com/medline/citation/23178044/Development_of_a_recombinant_vaccine_against_infectious_coryza_in_chickens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(12)00330-X DB - PRIME DP - Unbound Medicine ER -