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Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test.
Eur J Pharmacol. 2013 Jan 05; 698(1-3):286-91.EJ

Abstract

The opioid system has been implicated as a contributing factor for major depression and is thought to play a role in the mechanism of action of antidepressants. This study investigated the involvement of the opioid system in the antidepressant-like effect of hesperidin in the mouse forced swimming test. Our results demonstrate that hesperidin (0.1, 0.3 and 1 mg/kg; intraperitoneal) decreased the immobility time in the forced swimming test without affecting locomotor activity in the open field test. The antidepressant-like effect of hesperidin (0.3 mg/kg) in the forced swimming test was prevented by pretreating mice with naloxone (1 mg/kg, a nonselective opioid receptor antagonist) and 2-(3,4-dichlorophenyl)-Nmethyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl] acetamide (DIPPA (1 mg/kg), a selective κ-opioid receptor antagonist), but not with naloxone methiodide (1 mg/kg, a peripherally acting opioid receptor antagonist), naltrindole (3 mg/kg, a selective δ-opioid receptor antagonist), clocinnamox (1 mg/kg, a selective μ-opioid receptor antagonist) or caffeine (3 mg/kg, a nonselective adenosine receptor antagonist). In addition, a sub-effective dose of hesperidin (0.01 mg/kg) produced a synergistic antidepressant-like effect in the forced swimming test when combined with a sub-effective dose of morphine (1 mg/kg). The antidepressant-like effect of hesperidin in the forced swimming test on mice was dependent on its interaction with the κ-opioid receptor, but not with the δ-opioid, μ-opioid or adenosinergic receptors. Taken together, these results suggest that hesperidin possesses antidepressant-like properties and may be of interest as a therapeutic agent for the treatment of depressive disorders.

Authors+Show Affiliations

Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, CEP 97650-000, Itaqui, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23178563

Citation

Filho, Carlos B., et al. "Kappa-opioid Receptors Mediate the Antidepressant-like Activity of Hesperidin in the Mouse Forced Swimming Test." European Journal of Pharmacology, vol. 698, no. 1-3, 2013, pp. 286-91.
Filho CB, Del Fabbro L, de Gomes MG, et al. Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test. Eur J Pharmacol. 2013;698(1-3):286-91.
Filho, C. B., Del Fabbro, L., de Gomes, M. G., Goes, A. T., Souza, L. C., Boeira, S. P., & Jesse, C. R. (2013). Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test. European Journal of Pharmacology, 698(1-3), 286-91. https://doi.org/10.1016/j.ejphar.2012.11.003
Filho CB, et al. Kappa-opioid Receptors Mediate the Antidepressant-like Activity of Hesperidin in the Mouse Forced Swimming Test. Eur J Pharmacol. 2013 Jan 5;698(1-3):286-91. PubMed PMID: 23178563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test. AU - Filho,Carlos B, AU - Del Fabbro,Lucian, AU - de Gomes,Marcelo G, AU - Goes,André T R, AU - Souza,Leandro C, AU - Boeira,Silvana P, AU - Jesse,Cristiano R, Y1 - 2012/11/20/ PY - 2012/05/30/received PY - 2012/10/27/revised PY - 2012/11/01/accepted PY - 2012/11/27/entrez PY - 2012/11/28/pubmed PY - 2013/6/12/medline SP - 286 EP - 91 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 698 IS - 1-3 N2 - The opioid system has been implicated as a contributing factor for major depression and is thought to play a role in the mechanism of action of antidepressants. This study investigated the involvement of the opioid system in the antidepressant-like effect of hesperidin in the mouse forced swimming test. Our results demonstrate that hesperidin (0.1, 0.3 and 1 mg/kg; intraperitoneal) decreased the immobility time in the forced swimming test without affecting locomotor activity in the open field test. The antidepressant-like effect of hesperidin (0.3 mg/kg) in the forced swimming test was prevented by pretreating mice with naloxone (1 mg/kg, a nonselective opioid receptor antagonist) and 2-(3,4-dichlorophenyl)-Nmethyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl] acetamide (DIPPA (1 mg/kg), a selective κ-opioid receptor antagonist), but not with naloxone methiodide (1 mg/kg, a peripherally acting opioid receptor antagonist), naltrindole (3 mg/kg, a selective δ-opioid receptor antagonist), clocinnamox (1 mg/kg, a selective μ-opioid receptor antagonist) or caffeine (3 mg/kg, a nonselective adenosine receptor antagonist). In addition, a sub-effective dose of hesperidin (0.01 mg/kg) produced a synergistic antidepressant-like effect in the forced swimming test when combined with a sub-effective dose of morphine (1 mg/kg). The antidepressant-like effect of hesperidin in the forced swimming test on mice was dependent on its interaction with the κ-opioid receptor, but not with the δ-opioid, μ-opioid or adenosinergic receptors. Taken together, these results suggest that hesperidin possesses antidepressant-like properties and may be of interest as a therapeutic agent for the treatment of depressive disorders. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/23178563/Kappa_opioid_receptors_mediate_the_antidepressant_like_activity_of_hesperidin_in_the_mouse_forced_swimming_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(12)00934-X DB - PRIME DP - Unbound Medicine ER -