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IBS and the role of otilonium bromide.
Int J Colorectal Dis. 2013 Mar; 28(3):295-304.IJ

Abstract

INTRODUCTION

Awareness of the seriousness of irritable bowel disorder (IBS) remains low among clinicians. In this review, we summarize the current knowledge of IBS and highlight the major personal, economic, and social burden of the disease, and the importance of adequate treatment of what is still often viewed as a trivial disorder. In fact, IBS is a major reason for referral.

PATHOPHYSIOLOGY

It is crucial that the varied pathophysiologies of this complex heterogeneous disease are understood in order to be able to treat both the presenting symptoms (pain, bloating, flatulence, abnormal defecation, diarrhea, constipation) and the underlying disorder effectively. Low-grade inflammatory and immune activation has been observed, but the precise triggers and mechanisms, and the relevance to symptom generation, remain to be established.

TREATMENT

IBS patients require different treatment strategies according to the pattern, severity, frequency, and symptoms. While initial therapy traditionally targets the most bothersome symptom, long-term therapy aims at maintaining symptom control and preventing recurrence. In addition to dietary/lifestyle interventions and psychosocial strategies, a wide range of pharmacologic therapies are approved for use in IBS depending on the symptoms reported. Musculotropic spasmolytics, which act directly on intestinal smooth muscle contractility, such as otilonium bromide, are effective, particularly in the relief of abdominal pain and bloating, and are well tolerated in IBS. THE OBIS TRIAL: The recent large placebo-controlled Otilonium Bromide in Irritable Bowel Syndrome study demonstrated the superiority of otilonium bromide versus placebo not only in the reduction of pain and bloating, but also in protection from relapse due to the long-lasting effect.

Authors+Show Affiliations

Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23178991

Citation

Boeckxstaens, Guy, et al. "IBS and the Role of Otilonium Bromide." International Journal of Colorectal Disease, vol. 28, no. 3, 2013, pp. 295-304.
Boeckxstaens G, Corazziari ES, Mearin F, et al. IBS and the role of otilonium bromide. Int J Colorectal Dis. 2013;28(3):295-304.
Boeckxstaens, G., Corazziari, E. S., Mearin, F., & Tack, J. (2013). IBS and the role of otilonium bromide. International Journal of Colorectal Disease, 28(3), 295-304. https://doi.org/10.1007/s00384-012-1598-0
Boeckxstaens G, et al. IBS and the Role of Otilonium Bromide. Int J Colorectal Dis. 2013;28(3):295-304. PubMed PMID: 23178991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IBS and the role of otilonium bromide. AU - Boeckxstaens,Guy, AU - Corazziari,Enrico S, AU - Mearin,Fermín, AU - Tack,Jan, Y1 - 2012/11/22/ PY - 2012/10/15/accepted PY - 2012/11/27/entrez PY - 2012/11/28/pubmed PY - 2013/8/15/medline SP - 295 EP - 304 JF - International journal of colorectal disease JO - Int J Colorectal Dis VL - 28 IS - 3 N2 - INTRODUCTION: Awareness of the seriousness of irritable bowel disorder (IBS) remains low among clinicians. In this review, we summarize the current knowledge of IBS and highlight the major personal, economic, and social burden of the disease, and the importance of adequate treatment of what is still often viewed as a trivial disorder. In fact, IBS is a major reason for referral. PATHOPHYSIOLOGY: It is crucial that the varied pathophysiologies of this complex heterogeneous disease are understood in order to be able to treat both the presenting symptoms (pain, bloating, flatulence, abnormal defecation, diarrhea, constipation) and the underlying disorder effectively. Low-grade inflammatory and immune activation has been observed, but the precise triggers and mechanisms, and the relevance to symptom generation, remain to be established. TREATMENT: IBS patients require different treatment strategies according to the pattern, severity, frequency, and symptoms. While initial therapy traditionally targets the most bothersome symptom, long-term therapy aims at maintaining symptom control and preventing recurrence. In addition to dietary/lifestyle interventions and psychosocial strategies, a wide range of pharmacologic therapies are approved for use in IBS depending on the symptoms reported. Musculotropic spasmolytics, which act directly on intestinal smooth muscle contractility, such as otilonium bromide, are effective, particularly in the relief of abdominal pain and bloating, and are well tolerated in IBS. THE OBIS TRIAL: The recent large placebo-controlled Otilonium Bromide in Irritable Bowel Syndrome study demonstrated the superiority of otilonium bromide versus placebo not only in the reduction of pain and bloating, but also in protection from relapse due to the long-lasting effect. SN - 1432-1262 UR - https://www.unboundmedicine.com/medline/citation/23178991/IBS_and_the_role_of_otilonium_bromide_ L2 - https://doi.org/10.1007/s00384-012-1598-0 DB - PRIME DP - Unbound Medicine ER -